Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 151 for “"spheroids"”.
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Endogenous Stress Signaling within Human Multicellular Aggregates (Spheroids)
… to non-adherent multicellular aggregates. These "spheroids" can be maintained at room temperature under oxygen- and nutrient-deprived conditions for extended periods of time (weeks) as well as converted back to viable proliferating monolayers. Herein it is shown that HEK293 spheroid arrest and …
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Structural and Photometric Properties of Extragalactic Stellar Spheroids
… Two distinct families of low luminosity spheroids are identified, and their properties compared.
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Evolution of Galaxies - Star Formation Histories in Nearby Spheroids
This thesis is about an investigation into the formation of spheroidal type galaxies. The investigation began with modelling studies of early-type galaxies and spiral bulges (SBs). From galaxy formation modelling studies led by experiments with a sample galaxy, some results were obtained; nonsolar …
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Virtual Planar Motion Mechanism Testing of 8:1 Spheroids
… provided, which discusses the flow topology of spheroids at steady angle of attack, validity of quasi-steady models, and some other basic flow features seen in PMM testing. In this paper, a simple proportionality relationship between a linear and quadratic damping model is revealed. It is also …
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Biophysical Influence of Nanofiber Networks to Direct Pericyte Aggregation into Spheroids
Multicellular spheroids have emerged as a promising tool for drug delivery, cancer therapy, and tissue engineering. Compared to 2D monolayers, spheroids provide a more realistic representation of the 3D cellular environment, enabling better understanding of the signaling cascades and growth factors …
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Investigation of different light delivery schemes in photodynamic therapy of human glioma spheroids
The response of human glioma spheroids to ALA-mediated photodynamic therapy subjected to various optical dose delivery schemes is investigated. In particular, the effects of fluence, fluence rate, light dose fractionation and long-term repeat PDT is considered. Improved PDT response was found for …
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Mapping viability and oxygen concentration in spheroids: A noninvasive approach with EPR imaging
… used to measure local (O$\sb2$) and viability in spheroids. The goal of this thesis was to overcome these limitations by developing a single noninvasive technique, based on Electron Paramagnetic Resonance Imaging (EPRI), which would provide simultaneous measurements of the distribution of …
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The effect of hypoxia and 3D culture conditions on heterogeneous ovarian cancer spheroids
… adhesion molecules to enhance cell motility and spheroids disaggregation, and up-regulating invasiveness markers and stemness makers to promote ovarian cancer aggressive potential. Hypoxia and spheroid formation decreased ovarian cancer cells growth but increased the chemoresistance, which leads …
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CHARACTERIZATION OF EPCAM IN THYROID CANCER BIOLOGY BY THREE-DIMENSIONAL SPHEROIDS IN VITRO MODEL.
Thyroid cancer (TC) is the most common Endocrine malignancy. Currently, the mechanisms responsible for insensitivity to therapeutic treatments, tumor aggressiveness and tumor relapse described in undifferentiated thyroid cancers (UTCs) haven’t been fully elucidated yet. The insurgence of therapy …
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Analysis of DNA damage and repair responses in cerium exposed cells and hepatocyte spheroids
… simple and effective approach is to create liver spheroids. Spheroids are cell aggregates that spontaneously form when cells are placed in low attachment environments. In this thesis, I describe the creation of a patterned agarose array for high-throughput spheroid formation and test its …
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Mitochondrial Quality Control Adaptations Support Malignant Progression of Serous Ovarian Cancer Cells and Spheroids
Serous ovarian cancer is the 5th leading cause of cancer-related deaths in women, with a 30% survival rate when spread into the highly hypoxic and visceral peritoneal cavity. Despite efforts to treat this highly metastatic disease, traditional chemotherapeutic and cytoreductive therapies are unable …
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Evaluating Impact of Endothelial Cells on Drug Response of Lung Cancer Spheroids Using Microfluidic Chip
… cells, impact drug resistance in NSCLC spheroids. To achieve this, we used both conventional in vitro systems and a microfluidic platform. The standard in vitro model developed in previous work was used for spheroid generation and as a baseline for comparative analysis. However, it is …
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Combining a microfluidic platform with LC-MS for the detection of induced hepatotoxicity using primary hepatic spheroids
… metabolically active 3-dimensional liver spheroids, compared with conventional methods. HepG2 and primary rat hepatocyte spheroids were cultured in a microfluidic platform and exposed to drugs known to induce toxicity.;The cells were cultured for 4 days before being exposed to each drug …
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Multicellular spheroids of human tumor cells as an in vitro model for treatment responses of human tumors
Contains fulltext : mmubn000001_131440772.pdf (Publisher’s version ) (Open Access)
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The Influence of Human Umbilical Vein Endothelial Cells in the Formation of Glioblastoma Spheroids in Three-Dimensional Microwells
… results showed a significant cell lysis in 3D spheroids. The cell viability was decreased approximately 37%, 54% and 65% with 10, 50 and 100 MOIs, respectively. The infection of the Δ24RGD was found more effective on 3D spheroids when compared to 2D monolayer cell culture. These results …
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Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional Culture
… spheroid culture so equine BMSC (eBMSC) spheroids could inhibit intra-articular inflammation. The overarching hypothesis is that eBMSCs can be enhanced to produce an allogeneic eBMSC therapy that inhibits intra-articular inflammation. In vitro experiments compared differences in …
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