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Showing 1 to 20 of 151 for “"spheroid"”.
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Unsteady flow over a 6:1 prolate spheroid
The flow over a 6:1 prolate spheroid undergoing transient maneuvers is studied. The Dynamic Plunge-Pitch-Roll (DyPPiR) model mount provides the unique capability to simulate truly unsteady maneuvers in a wind tunnel. The DyPPiR is presented along with several transducer systems used to study …
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Investigating the Effect of an Upstream Spheroid on Tandem Hydrofoils
… investigate the influence of an upstream prolate spheroid body on tandem pitching hydrofoils. The model is validated by performing separate CFD simulations on the body and pitching hydrofoils and comparing results to existing experimental data. The simulations were run for a range of Strouhal …
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Three-dimensional Hyaluronan-based Hydrogels Designed for Breast Cancer Spheroid Formation
… enabled the long-term culture of breast cancer spheroids (CS). First, hydrogel stiffness was decoupled from the immobilization of cell-adhesive peptides using orthogonal oxime and Diels-Alder click chemistry. Breast CS formation on bifunctional HA hydrogels is dependent on hydrogel stiffness and …
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AI Assisted Cellular and 3D Spheroid Analyses for Combined Therapies Against Glioblastoma
… with lenalidomide (RT+Len, immunotherapy) in 3D spheroids, and temozolomide with graphene quantum dots (TMZ+GQD). Microscopy images at 24 and 48 hours were analyzed using k-means and hierarchical clustering with no labels or predetermined features. For RT+Vor, machine learning identified …
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Mean velocity and turbulence measurements of flow around a 6:1 prolate spheroid
… the three-dimensional flow around a 6:1 prolate spheroid model 1.37 m long were conducted in the separation and near wake regions along the leeward side. Mean velocity flow field measurements, at α = 10∘ and 15∘ , and at Re = 1.3 x 10⁶ (U<sub>re</sub>= 15.2 mls) and 4.0x 10⁶ (Ure=45.7 m/s), were …
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An experimental study of flow over a 6 to 1 prolate spheroid at incidence
… dependent issue, the flow over a 6 to 1 prolate spheroid, which is a generic three-dimensional body, is investigated. For the identification of the general flow pattern and better understanding of the flow field, surface-oil-flow visualization tests and force and moment tests were performed. The …
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The Perturbation of The Normal Mode Oscillations of a Rotating Fluid Spheroid by a Uniform Magnetic Field
Made available in DSpace on 2015-05-12T17:03:37Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 6200641.PDF: 2258848 bytes, checksum: 1a8aa421b585c9247fc80bed5b6ce1da (MD5) Previous issue date: 1961
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Octant Analysis of the Reynolds Stresses in the Three Dimensional Turbulent Boundary Layer of a Prolate Spheroid
… (x/L=0.76-0.78, φ=105°-130°) of a 6:1 prolate spheroid at 10° angle of attack. The Reynolds number for the flow was Re<sub>L</sub>=4.2x10⁺⁶. The LDV data of Chesnakas, Simpson, and Madden (1994) were the basis of examination. This data set employed a post-processing technique for refining the …
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Bridging the Scale Gap: linking 2D proteomic and 3D tumour spheroid morphometric data using partial least squares structural equation modelling
… as 3D aggregates of cells referred to as ‘spheroids’. These spheroid cultures often exhibit responses to therapeutic agents more similar to that of tumours and can serve to bridge the efficacy gap between 2D and tumours in situ. <br/><br/>This research examines the relationships between …
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Electromagnetic scattering and induction models for spheroidal geometries
… randomly distributed discrete dielectric spheroidal inclusions is studied. Also, the broadband magnetoquasistatic solution for the induced magnetic field from a conducting and permeable spheroid under time harmonic excitation is demonstrated. Analytical electromagnetic solutions for …
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The development and validation of a novel patient-derived 3D meningioma cell culture model
… easy-to-use in vitro patient-derived meningioma spheroid model that maintained the morphological and molecular features of the parental tumours, including tissue histology, the tumour microenvironment, and the mutational profile. Comprehensive characterisation of the global transcriptomes of the …
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Electromagnetic wave scattering by discrete random media with remote sensing applications
… (QMS) solution for a conducting and permeable spheroid under arbitrary excitation is presented. The spheroid is surrounded by a weakly conducting background medium. The magnetic field inside the spheroid satisfies the vector wave equation, while the magnetic field outside can be expressed as …
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Biophysical Influence of Nanofiber Networks to Direct Pericyte Aggregation into Spheroids
Multicellular spheroids have emerged as a promising tool for drug delivery, cancer therapy, and tissue engineering. Compared to 2D monolayers, spheroids provide a more realistic representation of the 3D cellular environment, enabling better understanding of the signaling cascades and growth factors …
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Non-Rayleigh scattering by a randomly oriented elongated scatterer
… of a randomly rough, randomly oriented prolate spheroid that is randomly located in a beampattern are investigated from physics-based principles both analytically and by Monte Carlo methods. This is a direct-path geometry in which reflections from neighboring boundaries are not a factor. The …
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Non-Rayleigh scattering by a randomly oriented elongated scatterer
… of a randomly rough, randomly oriented prolate spheroid that is randomly located in a beampattern are investigated from physics-based principles both analytically and by Monte Carlo methods. This is a direct-path geometry in which reflections from neighboring boundaries are not a factor. The …
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In-vitro Glioblastoma Treatment Focusing on Convection Enhanced Delivery
… delivery. A culture method to create large spheroids mimicking tumors from preexisting glioblastoma stem cell lines was fabricated, a convection enhanced delivery system for in-vitro testing was designed, and characterization of the CAR-T cells using the in-vitro system took place. The …
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The effect of hypoxia and 3D culture conditions on heterogeneous ovarian cancer spheroids
… evaluated the effects of hypoxic environment, spheroid formation as well as stromal vascular fractions (SVF) on the metabolic shift, proliferation rate, drug resistance and protein markers in functional categories. The results demonstrated an increasingly glycolytic nature of MOSE cells as they …
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Separation and wakes over three-dimensional bodies
The laminar flow over a prolate spheroid was investigated via flow visualization and Laser-Doppler Velocimetry. Experiments were conducted in a water tunnel and the flow was visualized with dyes. The measurement of three-dimensional boundary layers required a special design of the laser optics. …
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Enzymatic crosslinking of dynamic hydrogels for in vitro cell culture
… stiffening on pancreatic cancer cell survival, spheroid formation, and drug responsiveness. The crosslinking of PEG-peptide hydrogels was dynamically tuned to evaluate the effect of matrix stiffness on cell viability and function. Specifically, dynamic matrix stiffening inhibited cell …
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