Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 125 for “"specific antibody"”.
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Inhibition of horseradish peroxidase activity by specific antibody
… purpose of this research was to characterize the antibody-mediated inhibition of horseradish peroxidase activity. Inhibition of enzyme activity was determined when alternate substrates were used. Typical biphasic patterns of inhibition were observed with each of five electron donors and three …
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Termination of Immunologic Tolerance Utilizing Tolerated Antigen Complexed With Specific Antibody
Made available in DSpace on 2014-12-11T21:33:51Z (GMT). No. of bitstreams: 1 7500429.pdf: 2983419 bytes, checksum: 77de1e246d9f54e9530516eea9c485cb (MD5) Previous issue date: 1974
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Development and Characterization of A Bi-Specific Antibody Targeting Hla-A2/Pr1
… of a T cell receptor-like monoclonal antibody (h8F4) that targets PR1/HLA-A2 and eliminates AML xenografts by antibody-dependent cellular cytotoxicity (ADCC) following repeat dosing. To improve the potency of h8F4, we have developed a bi-specific T cell-engaging antibody that targets …
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Immunity surveillance of mumps and rubella: improved methods for the detection of virus-specific antibody
… laboratory methods for the detection of virus-specific antibody to mumps and rubella. The presence of virus-specific antibody is indicative of immunity to disease so simple and effective antibody detection allows for the planning and monitoring of immunisation programmes. In facilitating …
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Adenovirus Vectors as Potent Adjuvants in Vaccine Development
… Pfs25 to generate a robust and prolonged Pfs25-specific antibody response. We found that Ad5-pfs25, which expresses pfs25, generated a robust Pfs25-specific antibody response characterized by a higher titer, higher relative affinity, and broader IgG subclass switching as compared to …
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Mucosal and systemic immune responses induced by immunisation of cotton rats with recombinant adenoviruses
… with the recombinant adenoviruses to elicit gD-specific systemic and mucosal immunity and confer protection against BHV-1 challenge. Immunisation with gD-expressing vectors induced better immunity and protection than immunisation with tgD-expressing viruses. Mucosal immunisation with the …
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Analysis and optimization of immune responses elicited by Outer Membrane Vesicles (OMVs)
… to design vaccines to elicit protective antigen-specific T and B cell responses is missing. In this study we systematically investigated the antigen-specific B and T cell responses elicited by OMVs decorated with heterologous antigens. Regarding the B cell induction by OMVs, we selected and …
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The Production and Ingestion of Antibodies in Milk
… Ehrlich (13) postulated that colostrum had specific antibodies which were absorbed by the young, and that this factor gave protection from certain diseases. The udder may be stimulated to produce antibodies by the direct introduction of antigens through the teat meatus. The antigen …
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Examination of Molecular Mechanisms Underlying Developmental and Adult Learning-Associated Plasticity in the Rat Brain
… prevalent using immunocytochemistry with a Fos-specific and a Fos and Fos related protein-specific antibody. Results of the study showed that Fos and Fos-related antigens are differentially expressed in the developing brain prior to and during peak times of cell differentiation in a region- and …
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Establishment of a systematised approach for the development of novel diagnostics and therapeutics in the field of biotechnology
… the first part of this thesis was to generate an antibody against Nonylphenol for later use in biofilters for the elimination of Nonylphenol from waste water. For this purpose mice were immunised following different strategies. The immunisation according to High Zone Tolerisation led to the best …
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Regulation of Protective B cell Anti-Tumor Responses
… progression is complex and often overlooked. Specifically, little is known about the extent to which the specialized populations of innate-like B-1a and B-1b cells participate in and contribute to the anti-tumor immune response. The totality of work presented in this document demonstrates …
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Characterization and informed design of downregulating anti-epidermal growth factor receptor antibodies
… research has culminated in the approval of two antibody-based drugs against EGFR for cancer treatment, with numerous others in clinical trials. However, therapeutic efficacy of these drugs has been disappointingly low due to autocrine signaling, receptor mutation, and transport limitations, …
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Improving methods for cytokine immunotherapy of cancer
… of IL-2 immunocytokine synergized with tumor-specific antibody to significantly enhance therapeutic outcomes compared to monotherapy with immunocytokine, concomitant with increased tumor saturation and intratumoral cytokine responses. Examination of cell subset biodistribution showed that the …
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INVESTIGATING THE ROLE OF DENGUE-SPECIFIC IMMUNITY IN PROTECTION AND DISEASE USING SYMPTOMATIC MOUSE MODELS
… mouse models recapitulate the phenomenon of antibody-dependent enhancement (ADE): mice born to DENV1-immune mothers developed enhanced disease upon DENV2 infection. Utilising these models, we investigated the role of dengue-specific immunity in dengue disease. Firstly, we investigated the …
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Surface Enhanced Infrared Absorption on Au Nanoparticle Films for Optical Biosensing
… optical sensors for the ex-situ measurement of specific antibody-antigen coupling and the in-situ measurement of adsorbates (octadecanethiol, DNA) during the adsorption process.
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Comparing high-throughput methods to measure antibody dependent cellular cytotoxicity during HIV infection
… protective prophylactic RV144 vaccine were HIV-specific antibody responses, including those mediating natural killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC), there has been considerable interest in measuring alternative roles for HIV-specific binding antibodies. The aim of this …
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The Effects of Lead Acetate on Host Susceptibility to Trypanosoma Cruzi
… and viral infection causes decreases in antibody production, T cell recognition, and macrophage activity—all of which result in decreased host resistance to infection. The present study was conducted to determine the immunosuppressive effects of lead acetate in C57B1/6 mice challenged …
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Rational Design of Antibodies against Tau and Alpha-Synuclein
… ability to bind targets with high affinity and specificity. In earlier studies, an oligomer-specific antibody against Abeta was created to detect and quantify oligomers by applying a rational antibody design approach known as the cascade method. Here, we used this method to design a library of …
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The capsular polysaccharide of Actinobacillus pleuropneumoniae serotype 5A: role in serum resistance and characterization of the genetic basis for expression
… pleuropneumoniae synthesizes a serotype-specific capsular polysaccharide (CP) that protects this bacterium from host defenses. In the presence of anti-CP IgG, encapsulated A. pleuropneumoniae K17 was killed in precolostral calf serum (PCS) but not in normal serum used as a complement …
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