Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"species generation"”.
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Nanoclusters for Cancer Therapy: Assesment of Their Reactive Oxygen Species Generation and Stability
… and use this energy to generate reactive oxygen species, resulting in targeted cancer cell death. To be an effective photosensitizer, clusters must have long-lived excited states that can interact with oxygen to produce reactive oxygen species. This interaction between the excited state of …
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Photochemically produced reactive species generation by extracellular organic matter sensitizers from Chlamydomonas reinhardtii
… the potential to act as photosensitizers for the generation of reactive species, including singlet oxygen (1O2), hydroxyl radicals (•OH), and triplet excited dissolved organic matter (3DOM). These reactive species can play an essential role in the mineralization of dissolved organic matter, …
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Differential Cytotoxicity and Reactive Oxygen Species Generation in Pulmonary and Aortic Cells Exposed to Inorganic Arsenic and Monomethylarsonous Acid
… This study explores possible reactive oxygen species that may contribute to atherosclerosis and examines the different cytotoxic effects of iAs and MMAs on thoracic aorta smooth muscle cells (A7r5) and rat pulmonary arterial smooth muscle cells (rPASMC) in culture to look for the generation of …
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Novel Synthetic Compound, KR-22332, has radio-protective effect through inhibition of Mitochondrial Dysfunction and ROS Generation
… The cell viability, apoptosis, reactive oxygen species generation, and mitochondrial membrane potential as well as changes in the signal pathway related to apoptosis were investigated. Then, the embryotoxicity of KR-22332 were explored in a zebrafish model. Radiation-induced apoptosis and …
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Understanding and modulating macrophage metabolism for improving inflammatory functions against Trypanosoma cruzi infection
… receptor-α (PPAR-α), and oxidative species generation. This study tested two hypotheses: that macrophages infected with T. cruzi fail to metabolically and phenotypically shift to the pro-inflammatory phenotype, and that modulating PPAR-α is a strategy to improve macrophage function …
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Carbon Monoxide Generation and Transport from Compartment Fires
… was to gain a better understanding of the species generation and transport from enclosure fires. The species generation experiments were conducted with a half-scale ISO 9705 enclosure with three different ventilation conditions and heat release rates ranging from 50 kW to 500 kW. The …
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A Parametric Study of the Effect of Fire Source Elevation in a Compartment
… understanding of parameters controlling the species generation and transport from compartment fires. The experiments were performed in a half-scale ISO 9705 compartment and a 6.1 m long hallway connected in a head-on configuration. The buoyancy driven propane fire was provided by a burner and …
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The Effects of Cocaine and Ecstasy on Cardiac Myocytes and the Intact Myocardium
… homeostatic parameters including reactive oxygen species generation, intracellular calcium balance, NF-κB activity, gene expression, and left ventricular function. We conclude that cocaine and ecstasy are detrimental to the myocardium of the heart, causing several disturbances with pathological …
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Development of a protocol to examine red blood cell functional adaptations to intermittent hypoxia
… calcium accumulation, and reactive oxygen species generation indicating premature damage and cell death. Methodological considerations emphasize non-invasive blood sampling, minimal-risk hypoxic exposure, and reproducible lab methods to ensure feasibility and broad applicability. Rather …
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Mitochondrial regulation of CD8+ T cell cytotoxicity
… mTOR signalling, mitochondrial reactive oxygen species generation and the integrated stress response. Overall, this work uncovers a novel role for mitochondrial translation in CTL cytotoxicity and adds to the growing body of evidence revealing the multifaceted and crucial roles of mitochondria …
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Overactive NF-KB signaling as a druggable target and evaluation of parthenolide an NF-KB inhibitor in canine cancer
… diseases that carry dismal prognoses in both species: histiocytic sarcoma (HS), hemangiosarcoma (HSA), and disseminated mastocytosis (MCT). Lymphoma is one of the most common cancer types affecting dogs and humans, and therefore, novel therapeutic approaches are always needed. For all of these …
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The effects of E-cigarettes on pulmonary inflammation and inflammasome activation
… cytokine release and reactive oxygen species generation. Inflammatory complexes called the inflammasomes are known to initiate and potentiate inflammation and are classically activated by two signals, usually a PAMP (Pathogen Associated Molecular Pattern) and a DAMP (Danger Associated …
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The effect of helical carbon nanotubes on macrophage function
… proliferation, and elevated reactive oxygen species generation. Additionally, CNTs inhibit internalization of targets in multiple phagocytic cell lines. Mice and rats exposed to CNTs often develop pulmonary granulomas and fibrosis. Furthermore, CNTs in mouse models have immunomodulatory …
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KGF-1 and KGF receptor expression in human periodontal disease and in vitro microwounding-associated-ligand-independent KGFR activation
… KGFR activation. ROS (Reactive Oxygen Species) generation along the wound edge was associated with KGFR activation and scavenging of ROS reduced KGFR phosphorylation. The c-Src family inhibitor, PP1, significantly inhibited KGFR phosphorylation. Functionally cell migration was reduced …
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Targeted magnetic hyperthermia for lung cancer
… ablation of lung tumors, and is based on heat generation by magnetic materials, such as superparamagnetic iron oxide (SPIO) nanoparticles, when subjected to an alternating magnetic field. However, inadequate delivery of magnetic nanoparticles to tumor cells can result in sub-lethal temperature …
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From Protein Structure to Clinical Strategy: An In silico Investigation of Mitochondrial DNA Mutations in Type 2 Diabetes and Degenerative Disc Disease for Targeted Nutritional Interventions
… ATP production and increased reactive oxygen species generation, potentially providing a mechanistic link between mitochondrial genetic variation, metabolic dysfunction, and intervertebral disc degeneration. To explore clinical relevance, selected pathogenic mtDNA variants were genotyped in a …
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Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell
… of my study are: [i] cytokines induce ROS generation and oxidative stress via activation of phagocyte-like NADPH-oxidase [NOX2] such effects are comprised of Rac1 activation, p47phox phosphorylation, and gp91phox expression. I further confirmed that NOX2 is one of the sources for ROS …
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Aging Exacerbates Neutrophil Pathogenicity In Ischemic Stroke
… inflammation (increased reactive oxygen species generation, impaired neutrophil clearance). However, there are currently no published studies on the effects of age on neutrophil function and neutrophil-associated brain tissue damage after stroke.</p> <p>Neutrophils are believed to …
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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature
… polymerization, and increased reactive oxygen species generation) both in microvessels directly treated with thrombin and those far outside the instilled region (up to 1000 μm away), and the expansion of signaling into the untreated microvessels was due to intercellular communication mediated …
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Azione antiossidante del sulforafane: analisi in cellule cardiache in coltura ed in un modello animale di esercizio fisico
… the deleterious action of reactive oxygen species (ROS) on biomolecules. The mode of action of these compounds could be either to scavenge ROS directly or to trigger protective mechanisms inside the cell, thereby resulting in improved defense against ROS. Sulforaphane (SF) …
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