Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"spatial regulation"”.
-
Creating sustainable communities in 'NewcastleGateshead'
… and contained and subject to the process of spatial regulation from above i.e. power over. Rather than a straightforward process of spatial regulation to transform people and places, the process of regeneration involves uncertainties, negotiations, contestations and emotions between the …
-
Mechanisms underlying spatial control of exit from mitosis
… This work highlights the importance of spatial restriction of Ltel in the bud and Kin4 in the mother for the proper execution of chromosome segregation in anaphase. In the second part of this thesis I investigate the role of cytoplasmic microtubules in spatial regulation of the MEN. It …
-
Spatial Control of CDC42 Activation Regulates Cell Width and Growth Zone Formation
… cell wall history. These studies show that the spatial regulation of Cdc42 is a major determinant of cell width in exponentially growing cells, and influences the width of a growth zone formed do novo. Cdc42 is an essential regulator of growth that is conserved throughout eukaryotes, and so this …
-
Temporal control of vulval precursor cell fate patterning in Caenorhabditis elegans
… requires precise coordination of temporal and spatial cues to ensure that developmental events occur at the correct time and place. C. elegans vulval development offers a convenient experimental system for investigating the temporal and spatial regulation of multiple developmental decisions in …
-
The Mitotic Exit Network detects spindle position and anaphase entry
… to reposition the spindle. In addition to this spatial regulation, activation of the MEN is restricted to anaphase by inhibitory cyclin-dependent kinase (Cdk) phosphorylation of the MEN kinase cascade. During anaphase onset, Cdk activity decreases; creating a temporal signal that releases the …
-
Control of Chromosome Segregation by the Aurora B Complex
… activation, and provide a mechanism for the spatial regulation of spindle assembly.</p>
-
Controlling Tissue Matrix Assembly of Human Mesenchymal Stem Cells toward Engineering Native-like Bone, Cartilage, and Osteochondral Grafts
… was designed to enhance tissue integration and spatial regulation of supplements to direct stem cell differentiation into chondrogenic and osteogenic lineages and the formation of complete osteochondral constructs. Proof-of-concept experimentation was conducted in a large animal (pig) model of …
-
Characterisation of ALADIN’s function during cell division
… discovered that ALADIN is a novel factor in the spatial regulation of the mitotic regulator Aurora A kinase. Without ALADIN, active Aurora A spreads from centrosomes onto spindle microtubules, which affects the distribution of a subset of microtubule regulators and slows spindle assembly and …
-
Functional analyses of mitotic microtubule-binding complexes
… of dynein relies on precise temporal and spatial regulation of dynein activity. Dynein regulation is accomplished in part by the association of adaptor proteins with the dynein complex, including Nde1. Here, I show that Nde1 utilizes distinct intermolecular interactions to regulate …
-
The Roles of Midzone and Peripheral Mitochondrial Fission in Pulmonary Arterial Hypertension
… by MitoMeter. We gained novel insights into the spatial regulation of mitochondrial fission under cellular stress and better defined the role of MFF and Fis1 in fission in human PAH and healthy cells. Understanding the role of MFF and Fis1 in PAH provides valuable insights into mitochondrial …
-
Dynamic Shuttling of AGO2 to the Nucleus Relieves MicroRNA Repression
… of nuclear AGO2 localization on global microRNA regulation using a multipronged transcriptomics approach. We combined AGO2-eCLIP-sequencing, small-RNA-sequencing, and whole transcriptome sequencing to identify candidate gene targets bound by AGO2 that may be regulated by the most abundant …
-
Regulation of Surface Proteins Assembly on the Wall of Gram-Positive Bacteria
… precursor lipid II. This thesis deals with the spatial regulation of the sorting reaction, and the role sortase localization plays in the correct distribution of surface proteins. We have introduced a new immunofluorescence procedure to study the distribution of sub-surface antigens in …
-
The role of MK2/TTP pathway in regulating early development and innate immunity in zebrafish
… I developed an in vivo reporter assay to detect spatial regulation of mRNA stability by the MK2/TTP pathway in early zebrafish embryos which can also be used to test other potential TTP targets. MK2a is the zebrafish homolog of mammalian MK2. In mammals, MK2 is not active during early development …
-
Analysis of the functions of phosphoprotein phosphatase 1 catalytic subunits during cell division
… cell division. Additionally, I investigated the spatial regulation of PP1β during the late stages of cell division using an inducible system and found that ectopic expression of PP1β at the central spindle did not impact the levels of a common readout of cytokinesis failure. Overall, this work …
-
Spatial Dynamics and the Mechanoresponse in CD4+ T Cell Activation
… The work in this dissertation highlights the spatial and temporal dynamics that regulate the initial coupling of CD28 with TCR signaling and also dissects the mechanical properties conferred by downstream effectors that are required to relay CD28 costimulation. A reaction-diffusion model that …
-
Tracing RNA biography: in situ transcriptome profiling by novel spatial omics technologies
… and function are shaped by the spatiotemporal regulation of gene expression. This intricate pattern of gene expression is, in part, attained through the precise regulation of mRNA: its metabolism, transport, and translation within individual cells across spatial and temporal dimensions. …
-
Urban informality and food environments: Obesogenicity, business operations, and governance in Cape Town’s informal food retail sector
… governance. Existing policies focused mainly on spatial regulation and licensing, with limited recognition of the informal sector's role in shaping urban food environments. This regulatory gap constrained opportunities to leverage informal food retailers to promote healthier diets. Greater policy …
-
NOGGIN Transport in a Model Human Epiblast
… transport of morphogen inhibitors regulates the spatial availability of morphogens during embryogenesis. My study shed light on an important and unexpected level of regulation for the transport of morphogen inhibitors whose role in spatially restricting the spread of morphogen signaling …
-
Cell-type specificity and herbivore-induced responses of primary and terpene secondary metabolism in Arabidopsis roots
… in plants have to be regulated temporally and spatially. As more cost-efficient strategies, plants may induce their defense response only in the presence of the attacker or restrict constitutive defenses to specific tissues or cells. In this study, we investigated aspects of the spatial …
Page 1 of 2