Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"spastin inhibitor"”.
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Using Chemical Probes to Examine Cellular Activities
… probes by mutation can provide insight into inhibitor binding interactions and may provide morphological pharmacodynamic markers that allow for the identification of drug resistance or sensitivity. Here, I present a two-part thesis in which I (i) explore the role of spastin during late …
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Analyzing Resistance to Design Chemical Inhibitors of AAA Proteins
… drug's binding sites. As selective binding of inhibitors to their protein targets is mediated by specific interactions of the inhibitor with the protein backbone and side chains, mutations that disrupt these interactions can lead to resistance. Identifying resistance-conferring alleles can thus …