Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 109 for “"sox2"”.
-
The Role of SOX2 in Colon Cancer Progression
SRY (sex determining region Y)-box 2 (SOX2) is one the embryonic stem cell transcription factors that is capable of reprogramming adult differentiated cells into an induced pluripotent cell. SOX2 is amplified in various types of epithelial cancers and its high its expression correlates with poor …
-
Sox2-Dependent Transcriptional Control of Airway Differentiation In The Mouse Lung
… cells, basal cells, and neuroendocrine cells.SOX2 is a well-known conducting airway marker. SOX2 is a transcription factor that is known to be important in embryonic development and induction of pluripotent stem cells. We hypothesized that SOX2 controls cell differentiation in the conducting …
-
Oct4 and Sox2 regulate methylation at the Igf2/H19 imprinting control region
… that allowed cooperative binding of Oct4 and Sox2 in vitro. To determine at which developmental stage the octamers regulate ICR methylation, we created a knock-in mouse with mutations in the ICR that eliminate Oct4 binding. Maternal transmission of this mutant allele resulted in partial …
-
The Role of SOX2 in Molecular Circadian Clock Regulation and Suprachiasmatic Nucleus Development
The focal point of my doctoral research, Sox2, is a stem cell gene that has been extensively studied for its function in stem cell maintenance and proliferation, cellular reprogramming, neurogenesis, and tumorigenesis. Sox2 is expressed and maintained in stem cells of different tissues, including …
-
Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
… function of two SRY-related HMG-box (SOX) genes, SOX2 and SOX9, in human foetal lung progenitor cells. I show that although SOX2 is expressed in early stage progenitor cells it is dispensable for progenitor cell survival and self- renewal. By contrast, SOX9 is crucial for tip progenitor cell …
-
SOX2 is Associated with Changes in DNA Damage Repair and Cell Cycle Gene Expression and Regulates E2F1
… One potential biomarker my lab has identified is SOX2. The expression of SOX2 was linked to an increased Gleason score at diagnosis and decreased time to metastasis after biochemical recurrence. Previously, SOX2 was found to promote lineage plasticity and resistance to AR-targeted therapies in …
-
Exploiting a novel organotypic model of SOX2-driven early squamous lung cancer to identify potential routes to chemoprevention
… urgently needed. Using a novel in vitro model of SOX2-driven early SQC I performed a screen using tool compounds and compounds in late phase clinical development for potential efficacy in chemoprevention. I combined this approach with targeted genetic ablation studies to identify/characterise …
-
Sox2 co-occupies distal enhancer elements with cell-type-specific POU factors to specify cell identity in embryonic stem cells and neural precursor cells
Sox2 is a master regulator of two distinct cellular states, that of pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs), but what common or distinct roles Sox2 may play in these cell types not fully understood. Further, the molecular mechanisms by which Sox2 can …
-
Identification and validation of new therapeutic targets for squamous cell lung cancer
… survival oncogene and transcription factor SOX2 is dysregulated by gene amplification in a large proportion of LUSC tumours and has been implicated as a key driver in multiple preclinical functional studies. As a transcription factor, SOX2 itself makes a challenging drug target. New …
-
Expresión de SOX2 y Nanog en lesiones orales potencialmente cancerizables y en carcinoma de células escamosas de cavidad oral. Significado clínico y pronóstico
La transformación maligna de trastornos orales potencialmente cancerizables (TOPC) varía ampliamente, incluso en ausencia de características histológicas como la displasia epitelial. Existe una urgente necesidad por identificar nuevos biomarcadores capaces de predecir con mayor precisión el riesgo …
-
Role of host chromatin remodelling in Mycobacterium leprae-induced Schwann cell fate change
… purposes, and research has shown that Sox2, an early embryonic cell transcription factor, is reactivated in Schwann cells during this process. However, in the case of an infection by M. leprae, the bacteria hijacks this innate ability and manipulates the host cell machinery to keep the …
-
Direct generation of region-specific induced neural Precursors from adult human fibroblasts using non-viral and viral methods
… of the defined neural transcriptional factors SOX2 and PAX6. However, the understanding of the underlying gene changes that occur during reprogramming was limited, as gene characterisation in direct reprogramming of induced neural precursors (iNPs) often relies on the expression profile at the …
-
The control of Schwann cell myelination during development and after nerve injury
… Recently, the HMG transcription factor Sox2 was identified as a negative regulator of Schwann cell myelination in vitro, however its role in Schwann cell myelination in vivo has not yet been studied. This study therefore aimed to examine the role of Sox2 overexpression in Schwann cells …
-
Soft 3D fibrin matrices downregulate FAK expression to promote self-renewal of tumor-repopulating cells
… 3 lysine residue 9 (H3K9) de-methylation and Sox2 expression [1]. However, the underlying mechanism(s) by which soft 3D fibrin matrices promote H3K9 de-methylation and Sox2 expression remain elusive. In this study we show that focal adhesion kinase (FAK) regulates Sox2 expression and H3K9 …
-
Dissecting the function of MYEF2 in neural stem cells and glioblastoma
… is high expression of the transcription factor SOX2. SOX2 is known to be essential for GCS self-renewal. To understand further how SOX2 exerts its function in GSCs, the Pollard laboratory studied the interactome of SOX2. Using SICAP-MS – a method that looks at the on-chromatin interactors of the …
-
Dissecting the genomic and epigenomic alterations underlying glioblastoma
… role of key NSC transcription factors such as SOX2 and SOX9, in regulating self-renewal activity in GSCs and gliomagenesis. To study non-coding alterations and complex SVs, we compiled a large (n = 230) cohort of GBM tumours with whole genome sequencing data. We uncovered a lack of recurrent …
-
Mechanical Manipulation of Eukaryotic Chromatin by DNA-Binding Proteins
… 2, I characterize the dynamic interplay of Sox2 and H1 DNA binding activity. Both families constitute large classes of chromatin and DNA binding proteins that have been historically thought to be antagonistic regulators of each other, but the underlying mechanism is not well understood. …
-
Μοριακά δίκτυα δυνητικών stem κυττάρων στο κακόηθες μελάνωμα του δέρματος
… μελανώματος. Οι μεταγραφικοί παράγοντες EZH2, SOX2 και Oct4 αποτελούν μόρια – κλειδιά στον έλεγχο του ρυθμιστικού δικτύου του stemness των εμβρυϊκών stem κυττάρων (ESCs). Είναι πλέον γνωστό ότι η χρωματίνη στα ESCs περιλαμβάνει περιοχές με «αντιμαχόμενες» τροποποιήσεις ιστονών (bivalent …
-
Characterization of the Key Mouse Cochlear Developmental Genes for Auditory Hair Cell Regeneration
… proliferation of SCs by acute ablation of p27 or Sox2. Secondly, we overactivated Notch1 signaling in the mouse inner ear at different developmental stages, and found that the ability of Notch signaling in generating new HCs declines after birth. Last, we achieved reprogramming of neonatal and …
Page 1 of 6