Global ETD Search
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Showing 1 to 6 of 6 for “"sortilin"”.
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MOLECULAR RECOGNITION OF THYROGLOBULIN BY SORTILIN
… governing TG uptake remain poorly understood. Sortilin, a ubiquitous receptor involved in protein sorting and endocytosis, has been proposed as a key mediator of TG internalisation, particularly for its iodinated forms. However, the molecular basis of this interaction has remained elusive. …
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Investigating the Unique Mechanism of Action of CADA Analogs for Down-Modulating CD4, Sortilin, and ACE2
… down-modulation of several proteins (CD4, ACE2, sortilin) with the establishment of a pharmacokinetic profile of various biologically active CADA analogs. To achieve these goals, deuterium-labeled CADA analogs (CK147 and TL020) and several signal peptides (hCD4, mCD4, Q19A mCD4, Q16A Q19A mCD4) …
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UNDERSTANDING THE INFLUENCE OF TDP-43 LOSS-OF-FUNCTION ON NEUROTROPHIN SIGNALLING
… affects the proper splicing of the receptor Sortilin resulting in the generation of a soluble isoform. Sortilin functions as a trafficking receptor for neurotrophins and a co-receptor in pro-neurotrophin mediated death, and its soluble form results in reduced activity-dependent secretion of …
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Etablierung und Analyse von 'knock-out' Mausmodellen der σ1 Untereinheiten des AP 1 Komplexes
… in der Regulierung der Adipogenese des Proteins Sortilin, das im Fettgewebe von σ1B-defizienten Mäusen überexprimiert wird, erscheint möglich. Die σ1B-Defizienz ist also mit drei unterschiedlichen physiologischen Abläufen assoziiert: der Regulation des Wasserhaushalts, der synaptischen …
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Investigations into the Nature of the Endosomal System in Plasmodium falciparum
… putative cargo, a P. falciparum homolog of the sortilin family of protein sorting receptors, PfSortilin. Another protein, PfFCP, the sole FYVE domain-containing protein in the P. falciparum genome, was localized to the membrane of a specialized acidic organelle, known as the food vacuole, where …
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Insulin Regulated Trafficking of Glucose Transporter 4: A Kinetic Perspective
… Finally, we characterized the role of Sortilin, and demonstrated that many proteins reported to regulate Glut4 trafficking simply regulate Glut4 stability at a posttranslational level.