Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"somite"”.
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Spatial and temporal influence on the specification of migratory somite cells : experimental studies with avian embryos
… der lateralen Dermomyotomkante der brachialen Somiten unterliegen einer Delamination und wandern danach in die Extremitätenknospe ein. Es ist bekannt, daß diese migrierenden Zellen die Extremitätenmuskulatur bilden. Darüber hinaus sind sie Vorläufer von Endothelzellen sowohl für Blut- als auch …
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Cell Migration and Morphogenesis during Formation and Repair of Zebrafish Skeletal Muscle
… investigate the morphogenesis of the developing somite and the behaviour of its different compartments in vivo via 3D confocal time-lapse microscopy. I demonstrated that the epaxial and hypaxial somite regions show distinct morphogenesis that lead to the chevron-shape of the somite. Evidence is …
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A genetic analysis of somitogenesis in the Medaka (Oryzias latipes)
Somites are repeated epithelial segments that are generated in a rhythmic manner from the presomitic mesoderm (PSM) in the embryonic tailbud. Later, they differentiate into skeletal muscle, cartilage and dermis. Somitogenesis is regulated by a complex interplay of different pathways. Notch/Delta …
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Molecular and biochemical characterisation of phosphorylation-dependent NICD1 turnover: novel roles for CDK1 and CDK2
… species-specific manner through the formation of somites, which later give rise to the vertebral column, most skeletal musculature and dermis. Somites are gradually and periodically pinched off from the anterior end of the presomitic mesoderm (PSM). The rhythmicity of somitogenesis is regulated by …
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Investigation of cell movement and the associated cytoskeleton during chick gastrulation and somitogenesis
… lie either side of the neural tube separate into somites. As new somites form caudally, the more rostral somites undergo a process of morphogenesis. Each somite divides into two regions: the dermomyotome and the sclerotome. Little is known about the cytoskeletonduring this process. Signalling by …
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An Investigation of the Genesis of Lumbosacral Myeloschisis in the Chick Embryo
… over the blastoderm at the 13-, 14-, 15- or 16-somite stages. Defective embryos were examined histologically at 3-hour intervals from the time of treatment to 30 hours of reincubation and thereafter at 12-hour intervals until 66 hours of reincubation had elapsed. Another group of embryos was …
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Visualizing Cell Migration in Situ
… in muscle precursor cells migrating from the somite into the forelimb using embryo slices. New technologies were developed to stabilize slices within the microscopic field and to apply surface support along cut margins of the slice to prevent exuberant outgrowth from the slice. Muscle …
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The Role of FGFR4 in Trigeminal Placode Cell Development
… gene construct was introduced into 6—10 somite stage chick embryos. This secreted inhibitory form of the FGFR4 gene blocked endogenous FGFR4 signaling, which resulted in trigeminal placode cells remaining in the ectoderm that would have normally begun migration into the mesenchyme. These …
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Die Rolle von cDermo-1 und cTwist im Vogelembryo
… development in the area directly overlying the somites. These cells also express Wnt-11 and are additionally promoted by an FGF signal. As opposed to the dorsomedial cells however, they are inhibited by Wnt-1. Finally, to support our hypothesis that a downregulation of En-1 in the dorsolateral …
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A novel genome-wide approach to identify in vivo targets of Notch signalling
… assays, the transgenic mice exhibit a severe somite/skeletal phenotype indicating that the tagged allele is hypomorphic. A detailed analysis of the phenotype revealed differential axial requirements for Hes7.
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Characterisation of the expression profile and endothelial function of Rho GTPase RhoJ
… musculature where it was involved in regulating somite formation. This study is the first to describe a role for RhoJ as a negative regulator of focal adhesion numbers and actomyosin contractility and to demonstrate a critical role of this Rho GTPase in endothelial cell migration and tube …
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Multi-scalar mechanisms timing axial progenitor contribution to the vertebrate body axis
… assay involves the heterochronic grafting of HH8 somite progenitors to a HH4 embryo. I show that HH8 somite progenitors undergo ingression through the primitive streak but are delayed relative to HH4 progenitors at the transition from ingressed to migratory mesenchyme, ultimately resulting in a …
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Analysis of the Zebrafish Segmentation Clock
… blocks of tissue flanking the notochord called somites. Somites are generated sequentially and periodically from an unsegmented tissue called the presomitic mesoderm (PSM) by a process called somitogenesis. <br></br><br></br> Underlying the periodicity of somitogenesis are transcriptional …
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Bioimaging of animal embryogenesis: mathematical methods and computational algorithms
… the formation of zebrafish brain at 7-8 somite stage with all the cells tracked starting from late sphere stage with less than 2% error for at least 6 hours. Our reconstruction opens the way to a systematic investigation of cellular behaviors, of clonal origin and clonal complexity of …
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Development and Evolution of the Skull-Neck Boundary: Insights from Amphibian Model Species
… axis and second with GFP-labelled somite cell-lineage tracing. The resulting morphologies indicate that it is likely that changing Hox gene expression domains resulted in the unique lissamphibian morphology at the occiput and the derived position of their skull-neck boundary. This …
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Development of transgenic Ambystoma mexicanum (axolotl) to study cell fate during development and regeneration
… We have discovered a contribution of somite cells to dorsal fin mesenchyme in the axolotl, which was previously assumed to derive solely from neural crest. We have also studied the role of blood during tail regeneration by transplanting the ventral blood-forming region from GFP+ …
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Investigating the relationship between clock gene stability and the pace of the vertebrate segmentation clock
Somites are precursors of the vertebrae, ribs, and associated musculature and their formation relies on ordered and timely segmentation during early embryonic development. Somites form as they ‘pinch’ away from the pre-somitic mesoderm (PSM) with a species-specific periodicity, coinciding with …
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THE IN-VIVO IMPACT OF SMPX MUTATIONS DURING DEVELOPMENT AND DISEASE
… aberrations in terms of length, and a general somite disorganization compared to those overexpressing the wild type human form. We also uncovered smpx expression in the neuromast mechanosensory hair cells of both anterior and posterior lateral line. The protein was localized throughout the …
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Roles for Chd7 in Zebrafish Development with Implications for Human Disease
… express <em>chd7</em> in the retina, brain and somite boundaries. We demonstrate that a reduction in Chd7 synthesis results in laterality defects in the expression of somitogenesis genes, consistent with the hypothesis that this chromatin remodeler is necessary for the proper development of the …
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The role of folic acid supplementation on exencephaly induced by maternal exposure to sodium valproate in the TO mouse
… a single high dose of FA administered at early somite stage does not prevent exencephaly. Three doses of FA administered daily from GD 5 through GD 10 restore and maintain plasma folate levels and significantly prevent exencephaly due to WA exposure in mouse embryos.
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