Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"somatostatin receptor"”.
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Atherosclerotic inflammation imaging using somatostatin receptor-2 positron emission tomography
… Up-regulation of the G-protein coupled receptor somatostatin receptor subtype-2 (SST2) occurs on the cell surface of activated macrophages. The central hypothesis tested in this thesis is that vascular SST2 PET imaging using 68Ga-DOTATATE might offer a more accurate marker of macrophage …
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Somatostatin Receptor 2 Regulation By C-Terminal Motifs and Pdz Domain Proteins
<p>Somatostatin receptor 2 (sst2) is a Gi-coupled G-protein coupled receptor that mediates many of somatostatin’s neuroendocrine actions. Sst2 is a clinically important GPCR as it is the drug target of somatostatin analogs such as octreotide, lanreotide, and pasireotide. Treatment with these …
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Effects Of Sustained Release Somatostatin Type 2 Antagonism On Glucagon Counterregulation And Glycemia In Type 2 Diabetic Rate Model
This thesis examined whether a novel somatostatin receptor 2 antagonist (SSTR2a), ZT-01, could enhance endogenous glucagon secretion and protect against hypoglycemia in a rat model of type 2 diabetes (T2D). Male Sprague Dawley rats were placed on a high-fat diet and injected with streptozotocin to …
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Evaluation of new diagnostic and treatment strategies in the management of the Zollinger-Ellison syndrome
… and tumour behaviour, (iii) study the effect of somatostatin receptor scintigraphy (SRS) on surgical cure rates, and (iv) assess the efficacy and safety of a new proton pump inhibitor (pantoprazole) in controlling acid hypersecretion.
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A BIOMARKER ENRICHMENT PHASE II TRIAL OF 177LU-DOTATATE IN METASTATIC NASOPHARYNGEAL CANCER WITH A SAFETY RUN-IN
… the prevalence and prognostic significance of somatostatin receptor 2 (SSTR2) expression in an international study comprising multiple clinical cohorts of 402 primary, locally recurrent and metastatic NPCs. We found significant correlation of SSTR expression with increased rates of survival and …
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Somatostatin inhibits insulin release via SSTR2 in the hamster pancreatic islets
<p>It is generally accepted that somatostatin receptor subtype 5 (SSTR5) mediates the inhibition of insulin release. This is due to the fact that in the human, rat, and mouse somatostatin (SST) inhibits insulin release via SSTR5; however, in a preliminary study from Dr. Hsu's laboratory with …
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Ligand-Directed Aavp to Deliver A Therapeutic Transgene to Neuroendocrine Tumors of The Pancreas
… These tumors do, however, consistently express somatostatin receptor type 2 (SSTR2) making them vulnerable to somatostatin analogs. Exploiting cell surface receptors overexpressed in tumors is a common avenue for ligand-directed delivery of imaging or therapeutic agents to tumors. In this …
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Multimodality Somatostatin Analog For Fluorescence-Guided Surgery In Cancer
… we evaluated the ability of the fluorescent somatostatin analog to selectively target tumors that overexpress the somatostatin receptor subtype-2 (SSTR2) and demonstrate utility for FGS. We used <sup>67</sup>Ga/<sup>68</sup>Ga for quantitative biodistribution studies and cross-validated …
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Imaging Post-Infarct Myocardial Inflammation with ⁶⁸Ga-DOTATATE PET/MRI and insights into COVID-19 associated myocardial injury
… is a PET radiotracer with high affinity for somatostatin receptor subtype 2 (SST2), which has been shown to be up-regulated in pro-inflammatory macrophages. Aims: To investigate the role of hybrid <sup>68</sup>Ga-DOTATATE PET/MRI for tracking post-infarct myocardial inflammation and …
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Charakterisierung von Somatostatinrezeptor-Subtyp 4 interagierenden Proteinen in der Ratte (Rattus norvegicus)
Somatostatin ist ein regulatorisches Peptid, das eine Vielzahl von biologischen Prozessen innerhalb des Körpers beeinflußt. Die Wirkung von Somatostatin wird auf zellulärer Ebene über eine Familie von fünf G-Protein-gekoppelten Rezeptoren vermittelt, die entweder in G Protein-abhängiger Weise oder …