Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"somatostatin"”.
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Multimodality Somatostatin Analog For Fluorescence-Guided Surgery In Cancer
… we evaluated the ability of the fluorescent somatostatin analog to selectively target tumors that overexpress the somatostatin receptor subtype-2 (SSTR2) and demonstrate utility for FGS. We used <sup>67</sup>Ga/<sup>68</sup>Ga for quantitative biodistribution studies and cross-validated …
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Atherosclerotic inflammation imaging using somatostatin receptor-2 positron emission tomography
… Up-regulation of the G-protein coupled receptor somatostatin receptor subtype-2 (SST2) occurs on the cell surface of activated macrophages. The central hypothesis tested in this thesis is that vascular SST2 PET imaging using 68Ga-DOTATATE might offer a more accurate marker of macrophage …
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Somatostatin inhibits insulin release via SSTR2 in the hamster pancreatic islets
<p>It is generally accepted that somatostatin receptor subtype 5 (SSTR5) mediates the inhibition of insulin release. This is due to the fact that in the human, rat, and mouse somatostatin (SST) inhibits insulin release via SSTR5; however, in a preliminary study from Dr. Hsu's laboratory with …
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Functional relationship between forebrain cholinergic projections and somatostatin neurons in the rat
… the substantia innominata to the cortex, and the somatostatinergic neurons in the hippocampus and cortex. The functional relationship between these two types of neurons was investigated using folic acid, a neuro-excitant, and cysteamine, a somatostatin depleter. Folic acid causes a neuron to fire …
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Somatostatin Receptor 2 Regulation By C-Terminal Motifs and Pdz Domain Proteins
<p>Somatostatin receptor 2 (sst2) is a Gi-coupled G-protein coupled receptor that mediates many of somatostatin’s neuroendocrine actions. Sst2 is a clinically important GPCR as it is the drug target of somatostatin analogs such as octreotide, lanreotide, and pasireotide. Treatment with these …
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Factors affecting luteinizing hormone releasing hormone and somatostatin release from rat hypothalami in virto
… releasing hormone (LHRH) and immunoreactive somatostatin (IRS), investigated. The viability of the tissue was assessed by oxygen consumption and by the rate of protein synthesis. Protein synthesis continued for up to 60 min but declined rapidly during the next 60 min of incubation. Amino acid …
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Macronutrient Intake, Growth Hormone-Releasing Factor and Somatostatin During Zinc Deficiency and Repletion in Rats
… of GRF and it's counter-regulatory partner, somatostatin (SRIF), were measured in Zn$-$ and zinc repleted rats to determine if these peptides correlated with the transient increase in protein intake observed in zinc repletion. There were no differences in total GRF content or GRF mRNA in …
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Chronic stress-dependent activation of somatostatin neurons in the nucleus accumbens facilitates maladaptive eating behaviors
… cellular changes. Because deficits in the somatostatin (SOM) neurons have been implicated in mice exhibiting traits of anxiety and depression, this neuron subtype may play an important role in modulating negative behavioral emotionality. Here I report an abundance of somatostatin neurons, …
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Effects Of Sustained Release Somatostatin Type 2 Antagonism On Glucagon Counterregulation And Glycemia In Type 2 Diabetic Rate Model
This thesis examined whether a novel somatostatin receptor 2 antagonist (SSTR2a), ZT-01, could enhance endogenous glucagon secretion and protect against hypoglycemia in a rat model of type 2 diabetes (T2D). Male Sprague Dawley rats were placed on a high-fat diet and injected with streptozotocin to …
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Ligand-Directed Aavp to Deliver A Therapeutic Transgene to Neuroendocrine Tumors of The Pancreas
… These tumors do, however, consistently express somatostatin receptor type 2 (SSTR2) making them vulnerable to somatostatin analogs. Exploiting cell surface receptors overexpressed in tumors is a common avenue for ligand-directed delivery of imaging or therapeutic agents to tumors. In this …
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Präparation und Charakterisierung von Liposomen zum passiven und aktiven Targeting
… Durch eine Oberflächenmodifikation mit Somatostatin wurde eine spezifisches Ansteuern von Somatostatinrezeptor exprimierenden Zellen erreicht. <br>Zu Beginn der Arbeit wurden neue Möglichkeiten zur Doxorubicinbeladung von Ei-Phosphatidylcholin (EPC)/Cholesterol (7/3 mol/mol) Liposomen …
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ΤΑ ΠΕΠΤΙΔΙΑ ΣΩΜΑΤΟΣΤΑΤΙΝΗ, ΝΕΥΡΟΤΑΣΙΝΗ ΚΑΙ Β-ΕΝΔΟΡΦΙΝΗ ΣΤΟ ΚΕΝΤΡΙΚΟ ΝΕΥΡΙΚΟ ΣΥΣΤΗΜΑ ΤΟΥ ΣΚΑΝΤΖΟΧΟΙΡΟΥ ΚΑΙ ΤΟΥ ΠΡΟΒΑΤΟΥ
… THE MORPHOLOGY AND REGIONAL DISTRIBUTION OF SOMATOSTATIN (SRIF)-, NEUROTENSIN (NT)-, AND B-ENDORPHIN-CONTAINING NEURONS IN THE HEDGEHOGAND SHEEP CENTRAL NERVOUS SYSTEM WERE INVESTIGATED USING IMMUNOCYTOCHEMISTRY.FROZEN CORΟNAL SECTIONS OF THE BRAIN AND SPINAL CORD WERE PROCESSED FOR …
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Regulation of duodenal mucosal bicarbonate secretion
… bicarbonate secretion can be inhibited by somatostatin and acetazolamide. Somatostatin selectively suppresses carbachol-stimulated and VIP-stimulated duodenal bicarbonate secretion, but not PGE2-stimulated bicarbonate secretion. Receptors for somatostatin coupled to adenylate cyclase could …
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Sampling Strategies for Characterization of Neuropeptides Using Mass Spectrometry and Functional Implications Into Cell -Cell Signaling
… AVP was detected in all samples. Interestingly, somatostatin [92-100] and provasopressin [151-168] were detected in the mutant but not in the wild type or heterozygous pituitaries while somatostatin-14 was detected only in the heterozygous pituitary. In addition, the putative peptide …
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Interactions of islet hormones with acetylcholine and cholecystokinin-octapeptide in the isolated pancreas of normal and diabetic rats
… the islet hormones insulin, glucagon and somatostatin, the neurotransmitter acetyicholine (ACh), the gut hormone cholecystokinin octapeptide (CCK-8), sodium nitroprusside (SNIP), 8-Bromo guanosine 3'5' cyclic monophosphate (8-Br cOMP) and nerve stimulation on amylase secretion and …
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Manipulation of Endogenous Growth Hormone in Growing or Lactating Dairy Cattle: Effects on Production
… and arginine) and immunization against somatostatin were investigated as potential means of altering endogenous GH concentrations and animal production.
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Copper-64 radiopharmaceuticals for receptor-mediated tumor imaging and radiotherapy
This study investigated several somatostatin analogues labeled with copper-64 for imaging and targeted therapy of SSTr positive cancer. Among three new cross-bridged bifunctional chelators coupled to Y3-TATE, 64Cu-CB-TE2A-Y3-TATE had the most favorable tumor targeting properties. The introduction …
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Outcomes and optimal treatment of patients with Acromegaly
… explores the impact of treatment, focussing on somatostatin analogue therapy. Results confirm there remains a 30% increase in mortality in patients with acromegaly. Mortality was increased in patients with GH >2µg/L, but not in patients with raised IGF-I. This is the first study showing reduced …
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