Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"somatic mutagenesis"”.
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Somatic mutagenesis in humans with deficient DNA repair
… However, the potential impact of increased somatic mutation rates on the risk of developing cancer and the process of ageing is not known. In this thesis, two inherited syndromes associated with intestinal cancer predisposition were selected to investigate the mutation burdens and mutational …
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The mutational landscape of normal urothelium
… within an individual. The accumulation of these somatic mutations can ultimately result in oncogenic transformation. Cancer development is often a multi-step process, the earliest stages of which remain incompletely understood. Recent technological advances have enabled detection of somatic …
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Somatic Mutations in Ageing and Degenerative Disease
Following the first division of the zygote, somatic mutations begin to accumulate in all human cells. Daughter cells become increasingly mutated leading to mosaic tissues, composed of genetically heterogeneous clonal units. In recent years, large scale sequencing efforts have begun to characterise …
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Molecular Analysis of the Unconventional Export Machinery of HASPB, a component of the surface coat of Leishmania parasites
… a screening for clonal CHO mutants derived from somatic mutagenesis that are incapable of exporting HASPB, was performed. In such a CHO mutant cell line HASPB was myristoylated and palmitoylated and was mainly localized to the plasma membrane as judged by confocal microscopy and subcellular …