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Showing 1 to 19 of 19 for “"solvates"”.
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Crystal engineering and sorption studies of cyclotriveratrylene and C-methylcalix[4]resorcinarene solvates
Cyclotriveratrylene compounds crystallised from acetonitrile (1) and 2-butanone (4) are shown to be nearly isostructural, resulting in the formation of dimeric capsules, while the compound which crystallised from chloroform (3) results in the formation of layers of cyclotriveratrylene molecules …
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Supramolecular modification of selected antitubercular drugs
… drug isoxyl [specifically polymorphs, solvates, cyclodextrin (CD) inclusion complexes and cocrystals] and to isolate and characterise a range of solvated forms of the rifamycin antibioticsrifampicin and rifaximin.
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Experimental and computational approaches for control and prediction of solid-state of pharmaceuticals
… to be investigated. In case of olanzapine solvates XPac analysis provides a rationale of desolvation products by highlighting the close relationships between the forms and desolvated 'end product'. Statistical modelling analysis revealed that the physicochemical properties of the solvents …
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Mixed ion and electron conducting polymer composite membranes for artificial photosynthesis
… The polycation is a OH- containing polymer; PVA solvates this polycation and facilitates the ion conduction via Grotthuss mechanism. The membrane with proper composition has an exceptionally high OH⁻ conductivity of 151 mS/cm, 6.51 times as high as the commercial membrane Neosepta AHA. At the …
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2,4,6-Tris(isopropylamino)-1,3,5-trinitrobenzene : Probing the Impact of Crystal Packing Forces in the Dimorphs and the Cocrystals–Experimental and Theoretical Study
We attempted to obtain a large amount of solvates of 2,4,6-tris(isopropylamino)-1,3,5-trinitrobezene 1 and tried to embark on a systematic study (both experimentally and theoretically) of conformational effects of crystal packing. Here we describe their investigation by X-ray diffraction, thermal …
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The crystal landscape and cocrystallization of primary aromatic sulfonamides
… cocrystallization, eutectic compositions, solvates, biochemistry of sulfa drugs and crystal polymorphism. Chapter Two delves into the crystal landscape of the sulfonamide functional group. In this chapter we critically assess several simple primary aromatic sulfonamides identifying the …
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Crystal Engineering of Flavonoids
… forms of quercetin and hesperetin in the form of solvates and cocrystals were synthesized. These new crystal forms were characterized by various techniques: FT-IR, DSC (Differential Scanning Calorimetry), single X-ray diffraction, powder X-ray diffraction, TGA (Thermal Gravimetric Analysis) and …
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Investigation of drug ionic liquid salts for topical delivery systems
… in the form of neutral compounds, salts and solvates of neutral compounds and salts. About half of all drugs sold in the market are in the form of salts which are held together by ionic bonds along with some other forces. Recently, Ionic liquids (ILs) an interesting class of chemical …
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Effect of a wet granulation manufacturing process on the stability of a pharmaceutical drug product
… amorphous form and both chloroform and ethanol solvates would revert back to the anhydrous crystalline form within 7 days at ≥54%RH, however, below this %RH there was significant degradation of the active ingredient in the amorphous state, 6.4%-9.5% (n=3) when stored at 33%RH for 87 weeks. There …
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New Pre-Catalysts for Olefin Polymerisation and Ring-Opening Polymerisation of Lactides/Lactones
… free VO(OtBu)3 resulted in the formation of two solvates of compound 27. Imidazole (L20H), oxazole (L21H), α-diimine (L22), iminopyridine (L23, L24) and phenoxyimine (L25H – L29H) ligand sets have been treated with group 5 (Nb or Ta) chlorides or oxytrichlorides to afford compounds 28 – 50, which …
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Functional ionic liquids for use in pharmaceutical applications
… (FDA) as neutral compounds, salts, or solvates of said neutral compounds and salts. Yet, the solid crystalline form can have unexpected and unfavorable effects on properties such as solubility, bioavailability, efficacy, etc., due to different polymorphic forms of the API. A drug can be …
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Examination of stress-induced transformations within multicomponent pharmaceutical crystals
… stress-induced transformations of carbamazepine solvates and cocrystals. It details the effect of thermal decomposition on the surface and bulk properties of the products, possible seeding effects, and the interconversion between carbamazepine dihydrate and carbamazepine benzoquinone cocrystal. …
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Evaluation of Dose-Exposure-Response Relationships of Miltefosine and Discovery of Multicomponent Crystal Forms of Artesunate
… by PXRD,DSC, TGA, and FTIR. Finally, the solvates formed were desolvated by heating in an oven at 60°Cfor 24h and characterised using PXRD and DSC. This work employed the Simcyp population-PBPK platform to predict miltefosine plasma concentrations in a virtual population under different …
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X-ray crystallographic studies on the self-condensation products of o-aminobenzaldehyde and anthranilic acid and of the metal complexes of some related tetra-azamacrocycles.
… crystal structures of the tetramer and of two solvates of the trimer (CHCI3 and CH3CN.H2O) were determined. These two compounds, also, have a fused heptacyclic double saddle-shape overall structure. Their structures are compared with those of the TAAB salts. Related types of hydrogen bonding …
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Preformulation solid-state supramolecular beneficiation of selected active pharmaceutical ingredients and a novel drug candidate
… and experimental screening for polymorphs, solvates/hydrates, cyclodextrin (CD) inclusion complexes, pharmaceutical salts and co-crystals. Screening involved grinding and co-precipitation methods. Characterisation of new forms involved thermal analytical methods including hot stage …
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Synthesis and Characterization of Transition Metal Complexes of Multitopic, Third-Generation, Phenylene-Linked Bis(1-Pyrazolyl)Methane Ligands
… long-range magnetic order. Three different solvates of [Cu<sub>2</sub>(μ-F)(μ-<strong>Lm</strong>)<sub>2</sub>](BF<sub>4</sub>)<sub>3</sub> are diamagnetic between 5 and 400 K, thus showing strong antiferromagnetic exchange interactions of -600 cm<sup>-1</sup> or more negative.</p> …
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Beiträge zur Chemie von Hydroboraten BHnX4-n - (n = 1-4) des Lithiums, Natriums, Kaliums und Magnesiums
… eine Einkristallstrukturanalyse eines KBH4-Solvates. Durch Verwendung von 18-Krone-6 kann die Struktur des Kaliumborinats KH2BC5H10 (25) aufgeklärt werden. Da zwischen dem Borinat und dem Kaliumion hauptsächlich ionische Wechselwirkungen auftreten, zeigt es deutlich andere Bindungsparameter …
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Enabling safe and stable cycling of lithium metal batteries using advanced electrolytes and interfaces
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-05-01
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6,6’-Dimethoxygossypol: Molecular Structure, Crystal Polymorphism, and Solvate Formation.
<p>6,6’-Dimethoxygossypol (DMG) is a natural product of the cotton variety Gossypium barbadense and a derivative of gossypol. Gossypol has been shown to form an abundant number of clathrates with a large variety of compounds. One of the primary reasons why gossypol can form clathrates has been …