Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"solution nuclear magnetic resonance (NMR)"”.
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The Effects of S-glutathionylation on the Structure and Function of the Mitochondrial Calcium Uniporter (MCU)
… applying optical spectroscopy, light scattering, solution nuclear magnetic resonance (NMR) and live cell functional experiments. S-Glutathionylation increased solvent exposed hydrophobicity, destabilized and caused large structural perturbations in the MCU-NTD. An S-glutathiomimetic mutation was …
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Structure, Function & Dynamics At The Membrane
… the mitochondrial lipid cardiolipin at atomic resolution using solution nuclear magnetic resonance (NMR) techniques; this interaction is key to promoting apoptosis. After demonstrating that the protein was correctly folded in the reverse micelle solution used as a membrane mimetic, cardiolipin …
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Novel Algorithms for Automated NMR Assignment and Protein Structure Determination
… structure determination based on solution nuclear magnetic resonance (NMR) spectroscopy plays an important role in structural genomics. Unfortunately, current NMR structure determination is still limited by the lengthy time required to process and analyze the experimental data. A …
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Development of Amorphous Ternary Solid Dispersions of a Novel Anti-Tubercular Indole-2-Carboxamide Derivative with Curcumin/Clofazimine for Tuberculosis Treatment
… scanning (DSC). Infrared spectroscopy (IR), solution nuclear magnetic resonance (NMR), and molecular modeling studies (docking studies using MOE with the MMFF94x forcefield) were utilized to understand the interaction between compounds and polymers. In the case of ternary solid dispersions, …
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Novel Insights into the Role of the Smoothened Cysteine Rich Domain in Hedgehog Signalling
… the first structure of the Drosophila Smo CRD by solution Nuclear Magnetic Resonance (NMR) spectroscopy. The structure of the Smo CRD comprises primarily of four helices and is stabilized by disulfide bonds between the conserved cysteine residues. The tertiary structure of the Smo CRD is similar …
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Structural investigations of membrane-interacting proteins using nuclear magnetic resonance spectroscopy and other biophysical techniques
… using a range of biophysical methods such as solution nuclear magnetic resonance (NMR) spectroscopy, magic-angle spinning (MAS) solid-state NMR spectroscopy (SSNMR), dynamic light scattering (DLS), and molecular dynamics (MD). There are many biophysical techniques used for protein structure …
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Towards atomistic characterization of blood coagulation proteins by NMR spectroscopy
… dynamic loops that can be accessed using nuclear magnetic resonance (NMR) spectroscopy. Here, the nanocrystalline and membrane-bound forms of TF are investigated with solid-state NMR and compared to the previously published solution NMR sTF assignments. We have prepared several samples of …