Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"soluble receptors"”.
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Targeting of IL-1 and IL-18 in experimental arthritis using soluble receptors - A gene thereapeutic approach.
Contains fulltext : 19574.pdf (Publisher’s version ) (Open Access)
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Der humane lösliche Interleukin-6-Rezeptor: Reinigung aus Plasma, Charakterisierung und Nachweis der von einer alternativ gespleißten mRNA translatierten Form
The human soluble interleukin-6-receptor: Purification from plasma, characterization and identification of an isoform generated through alternative splicing Soluble receptors for cytokines are soluble forms of their membrane counterparts which bind their ligands with similiar affinities to those of …
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Synthesis of Organic and Water Soluble Cored Dendrimers With Internal Cross -Links
… is limited. Thus, the generatinn of novel, water soluble dendrimers as potential nanocontainers with larger capacities is desired. It was hoped that the development of water soluble, cored dendrimers could improve dendrimer capacity by increasing the ""cavities"" within the dendrimer by core …
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Herstellung und Charakterisierung hochaffiner Inhibitoren für die Zytokine IL-6 und LIF basierend auf den Liganden-bindenden Domänen ihrer Rezeptor-Untereinheiten
… cancer. While the importance of fused cytokine receptors for the treatment of dysregulated cytokine production has already been noticed, their mode of action has not been studied in detail. This should be carried out in the present study for the IL-6 inhibitor IL-6 receptor fusion protein …
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Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
… tumor progression. Interrogation of a set of soluble receptors revealed that wild-type, but not catalytic mutants of TMPRSS11B promotes membrane release of Basigin, an obligate chaperone of the lactate monocarboxylate transporters MCT1 and MCT4. To investigate whether TMPRSS11B regulates …
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Diseased Thyrocytes Have Aberrant Communication and TNF Receptor Secretion
… in the diseased thyrocytes caused an increase in soluble TNF- α receptor production. The production of soluble TNF- α receptors was not the result of proteolytic cleavage of the cell-surface receptor. Instead, the diseased thyrocytes may be secreting soluble receptors. We are the first to report …
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Therapeutic application of dominant-negative PDGF beta-receptor in liver fibrosis
… which exerts cellular effects by binding to PDGF receptors (PDGFR) and further inducing receptor dimerization and tyrosine-autophosphorylation, thus initiating various signaling pathways, amongst which MAPK and PI3K as principals. These PDGF signaling pathways may provide a potential therapeutic …
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Defining the molecular, genetic and transcriptomic mechanisms underlying the variation in glycation gap between individuals
… of specific SNPs via real time qPCR,determine soluble receptors for AGE (sRAGE) concentration via ELISA, finding association of sRAGE concentration with SNPs genotype, and evaluate relative average telomere length ratio via real time qPCR. This study also aimed at the investigation of …
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Immunodulation of inflammation in a murine pnemococcal sepsis model
… of ATL313 was through functional A2A adenosine receptors and if hematopoietic cells are important in the protective effect of A2AAR, C57BL/6 A2A-receptor-deficient mice, and chimera were used and groups of C57BL/6 mice were co-injected intraperitoneally with ATL313 and ZM243185 (antagonist …