Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"soluble factors"”.
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Soluble factors and remodeling in a synthetic stem cell niche
… niche is a host of biophysical, cellular, and soluble factor cues that combine in temporally and spatially organized zones which elicit distinct responses from resident HSCs. Clinically, HSC transplants are the most widely used regenerative therapy, treating disorders of the blood and immune …
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The role of soluble factors affecting the major histocompatibility complex class I molecules In an IN VITRO model of the fetomaternal interface
Human main histocompatibility complex is encoded in the short arm of chromosome 6 and can be divided into three main regions based on the proteins that it encodes. We have class I, class III and class II. Class I encodes for proteins that are expressed on the cell surface of almost all somatic …
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Inflammatory Breast Cancer: The Immune Perspective
… <p>Emerging evidence suggests that host factors in the microenviromement may interact with underlying IBC genetics to promote the aggressive nature of the tumor. An integral part of the metastatic process involves epithelial to mesenchymal transition (EMT) where primary breast cancer …
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Combinatorial Polymer Synthesis and High-Throughput Screening Technology to Identify Optimal Approaches for Mineralized Tissue Engineering
… new methods to accelerate the process of testing soluble factors or combinations of factors. To this end, a library of poly(β-amino ester)s has been developed as the first combinatorial library of photopolymerizable and biodegradable materials. Polymers formed from this library were characterized …
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Factors affecting bone cell growth and differentiation under differing culture conditions
… conditions for osteoblastic differentiation. Factors such as cell density, scaffold seeding method, scaffold thickness and secreted soluble factors were investigated. Soluble factors secreted by the differentiated cells into the culture medium were found to be critical for timely …
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Mesenchymal stem cells as trophic mediators of neural differentiation
… niche involving the release and/or uptake of soluble factors and cytokines, significantly influencing the behaviour of other cell types within the niche. Both facets of MSC behaviour are valuable from a clinical perspective, and have been examined in the present thesis. The most obvious and …
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Co-culture of hepatocytes with mesenchymal stem cells for cellular therapy in liver disease
… established to investigate the role of paracrine factors in hepatotrophic effect of MSCs co-culture. Hypoxia-preconditioned (HPc) MSCs were co-cultured with hepatocytes to investigate potentiative effect of HPc induction. Intracellular reactive oxygen species (ROS) activity quantitation and …
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An <i>in vitro</i> human 3D co-culture model to study endothelial-astrocyte interactions
… from the 2D HA in their ability to release soluble factors that induce barrier properties on BMVEC, as observed by similar levels of three expression markers of barrier phenotype on hCMEC/D3 cells namely, zonula occludens-l, claudin-5, and P-glycoprotein and similar paracellular permeability …
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Down-Regulation of Natural Killer Cell Activation in Response to Influenza Virus in Older Adults
… that NK cell IFN- 7 production, mediated by both soluble factors and cell-cell contact factors is down-regulated in elderly subjects compared to young subjects in response to influenza virus. As for soluble factors, IFN-o: and IFN- 7 are proven to be important in inducing NK cell to produce IFN-7 …
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Role of vascular remodeling in the accumulation, clearance, and biodistribution of biomolecular factors in melanoma
… such as immune suppression and metastasis. Soluble factors (SF) produced within the tumor, including cytokines, exosomes, proteases, and microvesicles, mediate pathological signaling and have emerged as putative therapeutic targets. However, SF bioavailability in distributed tissues and the …
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Engineering Biosurfaces for Cell Studies
… to other cell lines and to other ECM proteins or soluble factors.
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Astrocytes down-regulate microglial inflammatory responses
… mediators. Previously, it has been reported that soluble factors from cultured astrocytes are capable of suppressing microglial activation. However, brain injury affect not only microglia but astrocytes. Therefore, I examined how astrocytes in injury states modulate microglial activation. …
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Engineered N-cadherin substrates for stem cell differentiation
… neural differentiation of stem cells using soluble factors and cell adhesion matrix properties. These differentiation studies are often dependent on the density of cells plated on the substrate, which implies that there is an important role of cadherin-modulated cell-cell adhesion in …
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Microfluidic device for cytotoxicity screening
… studies such as the response of cells to water-soluble factors such as anti-cancer drugs as well as the dynamic binding of anti-bodies to adherent cells.
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Investigating heterogeneity and mechanisms of resistance in paediatric B-cell non-Hodgkin lymphoma
… to chemotherapy. In vitro, the SP produces soluble factors necessary for growth of the main population (MP) of cells (depleted of SP); indeed, MP and SP produce different cytokine profiles suggestive of cross-talk between the populations to maintain tumour cell growth. Furthermore, the PI …
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Analysis and implementation of the bilayer microfluidic geometry
… for a microfluidic device to uniformly deliver soluble factors to a given culture of cells without subjecting the cells to hydrodynamic shear stresses that could potentially alter their behavior in an unpredictable or undesirable way. This is especially true for a number of cell types, and …
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A microfabricated 3D tissue engineered "Liver on a Chip" : information content assays for in vitro drug metabolism studies
… by cell-cell and cell-matrix interactions, soluble factors, and mechanical forces. This thesis focuses on the design, fabrication, modeling and characterization of a microfabricated bioreactor system that attempts to mimic the in vivo microenvironment by allowing for the three dimensional …
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Investigating interplay between human regulatory T cells and oligodendrocyte lineage cells
… cells (Treg) impairs CNS remyelination and that soluble factors secreted from murine Treg promote OPC differentiation, this PhD Thesis hypothesized that human Treg recapitulate the effect of murine Treg in promoting the differentiation of human OPCs in vitro. To this end, human Treg subsets, …
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DISSECTING RESISTANCE TO IMMUNOTHERAPY IN MSS COLORECTAL CANCER
… sensitivity, our study delves into additional factors influencing the unresponsiveness of MSS CRCs to immune checkpoint blockade. To dissect these characteristics, we developed an experimental model for in vitro manipulation, establishing a controlled system using patient-derived organoids from …
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BIOCHEMICAL AND MORPHOLOGIC EFFECTS OF CAVITATION ON NORMAL HUMAN PLATELETS
… in response to sublytic shear stresses or to soluble factors leaked from mechanically disrupted platelets and their fragments. The clinical implications of this study are manifold.
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