Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"soluble epoxide hydrolase"”.
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Mechanistic and therapeutic evaluation of a novel antiantiogenic small molecule
… By photoaffinity pulldown, I identified soluble epoxide hydrolase (sEH) as an SH-11037-binding target. sEH is a key enzyme in ω-3 and ω-6 fatty acid metabolism. sEH levels were dramatically upregulated in retinal sections from L-CNV mice and a specific sEH inhibitor, t-AUCB, significantly …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… (EDP-EAs) that are known as omega-3 eCB epoxides. Previously, 17,18-EEQ-EA and 19,20-EDP-EA have shown to have anti-neuroinflammatory, vasodilatory, anti-angiogenic properties, activate cannabinoid receptors and regulate platelet aggregation in vitro. Although these metabolites have …
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Cytochrome P450 2J2 mediated metabolism of omega-6 and omega-3 endocannabinoids
… 2-AG yielded detectable levels of only two 2-AG epoxides. Additionally, 2-AG was shown to undergo enzymatic oxidative cleavage to form AA through a NADPH-dependent reaction with CYP2J2 and cytochrome P450 reductase. The demonstrated ability of CYP2J2 to oxygenate AEA and 2-AG raised questions …