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Showing 1 to 20 of 36 for “"soluble compounds"”.
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Mechanisms of polymer adsorption in nanoparticle stabilization for poorly water soluble compounds
<p>In this dissertation, the mechanisms of nanosuspension stabilization via polymer adsorption on nanoparticle surface were investigated. As the electrokinetic behavior and colloidal stability depend on the surface characteristics, altering the surface adsorbed polymers affords the different …
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Development and Evaluation of Ternary Amorphous Solid Dispersion of Poorly Water-soluble Compounds
… of this strategy. Recently, polyphenolic compounds such as curcumin (CUR) and resveratrol (RES) are shown to have synergistic antioxidant, chemo-preventive, chondroprotective, and anticancer activity. However, their poor aqueous solubility limits their oral application. The purpose of this …
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
… solubility profile of these difficult-to-deliver compounds. Intradermal delivery of poorly soluble drugs involves the delivery of drugs into the skin to exert localised effects. However, relatively few drugs possess the necessary properties to passively traverse the skin and remain in the skin in …
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Solubility Enhancement and Precipitation Inhibition of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology
… the miscibility and solubility of the model compounds within Soluplus® , of which felodipine demonstrated higher solubility when compared to ketoconazole (14% vs 4.3% w/w) at room temperature (298K). Moreover, the solubility parameters of FEL, KTZ and SOL were calculated as 21.76, 26.51 and …
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DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS
… release (CR) matrix system for poorly water-soluble drug in order to enhance its solubility and dissolution rate while maintaining the stability of the supersaturated state during and after dissolution. Two types of polymeric carriers, namely hydroxypropyl methylcellulose acetate succinate …
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Solubility enhancement, mechanical properties and taste masking of poorly water soluble compounds by optimizing hot melt extrusion processing
… the use of this route for the delivery of poorly soluble actives. Conventional delivery systems used for oral drug delivery are solid dosage forms including capsules filled with milled material, tablets, and pellets. Current research focusing on actives with low aqueous solubility requires new …
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Organo-iridium compounds: synthesis, characterization and reactivity
Today, few water-soluble organometallic compounds are known, and little research has been done in this area. Water-soluble organometallic complexes are of interest for two reactions. First, a water-soluble compound that could be developed as a catalyst eliminates the need for organic solvents and …
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The Possible Role of Extra-Gonadal Metabolism of Steroids in The Regulation of Plasma Steroid Levels (Cytochrome P-450, Liver)
… of metabolism of steroid hormones to more water soluble compounds can be influenced by a variety of factors including diet and exposure to lipophilic compounds. Phenobarbital, a commonly used sedative, is known to increase the rate of hepatic metabolism and elimination of estrogen, progesterone …
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Allelopathic Effects of Festuca Arundinaceae on the Growth of Juglans Nigra Seedlings
… in any experiment. Results suggest that water soluble compounds are present in fescue tops, are released through decomposition, and reduce walnut root growth.
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A study of the oxygenation of some manganese (II) tetradentate schiff base complexes
Manganese(II) complexes formed by the reaction of either salicylaldehyde or 5-chlorosalicylaldehyde and 1,4-diaminobutane (SALBTDA), 1,6-diaminohexane (SALHXDA), 1,8- diaminooctane (SALOTDA), and 1,10- diaminodecane (SALDCDA) have been isolated. The complexes Mn(SALHXDA), Mn(SALOTDA), and …
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Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying
… in enhancing the aqueous solubility of poorly soluble compounds. In this study, the mechanism of solubility enhancement was characterized using three model drugs-naproxen, ketoprofen and furosemide. Physical mixtures of the model drug with polyvinylpyrrolidine and spray dried composites were …
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Comparison of extraction efficiency using ethanol and methanol for the extraction of mycosporin-like amino acids (MAAs) from Palmaria palmata
… acids (MAAs) are low molecular weight, water soluble compounds widely distributed in marine organisms specially in seaweed, where they function as natural ultravoilet (UV) protective agents. Due to their strong UV-absorbing properties and antioxidant potential MAAs have gained increasing …
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Dynamic Botanical Filtration System for Indoor Air Purification
… the DBAF system in removing the volatile organic compounds, a series of further experiments were conducted to determine the important factors affecting the removal performance, and the roles of different transport, storage and removal processes. It was found that passing the air through the root …
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The Synthesis, Characterization, and Properties of Stiff, Hydrophilic, Dendritic, Phenylacetylene Macromolecules
… growth scheme. The structures of these organic soluble compounds were confirmed by a variety characterization techniques including NMR, mass spectrometry, elemental analysis, GPC, and HPLC. Careful analysis of an apparently pure dendrimer revealed the presence structures incorporating small …
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Predicting the Risk of Crystallization for Suspensions of Amorphous Spray Dried Dispersions from Structural, Thermal and Hydrophilicity Properties
… tool for enhancing the exposure of poorly soluble compounds in preclinical animal models. However, limitations in drug supply and time/cost of manufacture in the drug discovery space make it desirable to predict the likelihood of obtaining a physically stable (free from detectable …
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Incorporación de vitamina C en dietas larvarias y su implicación en el desarrollo de Solea senegalensis
… including the use of various materials and water-soluble compounds. In addition, the safety and efficacy of these techniques for water-soluble compound delivering in aquaculture were tested. The formulation, the microencapsulation protocol and the culture system used, allowed the replacement of …
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The fate and distribution of subsurface hydrocarbons released during the 2010 MC252 oil spill in deep offshore waters of the Gulf of Mexico
… 1,050 to 1,300 m below surface. Water soluble compounds were preferentially extracted from the rising oil in deepwater, and were found at potentially toxic levels both in and outside of areas previously reported to contain the majority of hydrocarbons. Data collected from different …
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Modeling effective isotopic fractionation in groundwater aquifers with heterogeneous reaction rates
… etc.) reduction reactions transform toxic, soluble compounds into non-toxic forms. Reduction induces isotopic fractionation, which may thus be used to determine the amount of reaction that has occurred. However, when the Rayleigh distillation equation is used to relate the isotope ratio …
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Singlet oxygen generating luminescent lanthanide complexes with naphthalimide-based and oligothiophene-based sensitizers
… excitation. Because of the interest in these compounds, systematic studies were used to help understand structure-property relationships. This work aims to synthesize and characterize multiple families of LnIII complexes that incorporate 1O2 generator moieties, specifically oligothienyl or …
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