Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"soluble TNF receptor"”.
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A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
… presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. ER export was facilitated by addition of a transmembrane (tm) sequence, and constitutive secretion was overcome by incorporating …
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Mechanisms for Targeting of Proteins to Secretory Lysosomes of Haematopoietic Cells
… targeting for storage of a protein such as the soluble TNF receptor to secretory lysosomes was achieved by addition of a transmembrane sorting signal. This might be useful in the use of secretory lysosomes of haematopoietic cells as vehicles for targeting of therapeutic molecules for local …
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Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture
… have the ability to influence T cell receptor (TCR) signaling and the maturational capacity of treated cultures. FTOC treated with low concentrations of nicotine produced more immature T cells and fewer mature T cells. These expanded populations of cells also expressed CD69, CD95 (FAS) …