Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"soluble N-ethylmaleimide-sensitive factor attachment protein receptor"”.
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An evolutionarily conserved regulatory mechanism for endosomal membrane trafficking
… cells is facilitated by the formation of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes; a process that is regulated by Sec1p/Munc18 (SM) proteins. Membrane fusion has been conserved through evolution and hence a lot or our knowledge about the molecular …
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Protein-Protein Interactions That Regulate Neurotransmitter Release From Retinal Ribbon Synapses
Protein-Protein Interactions That Regulate Neurotransmitter Release from Retinal Ribbon Synapses Photoreceptors and bipolar cells in the retina form specialized chemical synapses called ribbon synapses. This type of synapse differs physiologically from “conventional” chemical synapses. While …
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Single-molecule fluorescence resonance energy transfer study of SNARE-mediated membrane fusion
This is a comprehensive study of protein-mediated membrane fusion through single-molecule fluorescence resonance energy transfer (smFRET). Membrane fusion is one of the important cellular processes by which two initially distinct lipid bilayers merge their hydrophobic cores, resulting in one …
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Cryo-electron Microscopy of Reconstituted Membrane Fusion Systems
Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins are responsible for driving the fusion of biological membranes and are present across many different cell trafficiking systems. Synaptic SNARE proteins allow the release of neurotransmitters across synaptic …
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Unraveling the Molecular Mechanisms of Munc18 and Munc13 in Mast Cell Exocytosis
… The exocytosis is known to be mediated by Soluble N-ethylmaleimide sensitive factor Attachment protein REceptor (SNARE) complex where intertwined helix bundles provide energy to fuse lipid membranes. Furthermore, this process is regulated by indispensable proteins such as Munc18 and Munc13 …
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The Functional Organization of Synaptic Vesicle Pools In A Retinal Bipolar Neuron
… fusion at these synapses is the role of SNARE (Soluble N-ethylmaleimide sensitive factor Attachment Protein Receptor) proteins. Vesicles at conventional neurons undergo SNARE complex-mediated fusion. However a recent study has suggested that ribbon synapses involved in hearing can operate …
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INVESTIGATING THE ROLE OF SNAP29 AND THE AUTOPHAGY PATHWAY IN DROSOPHILA MELANOGASTER MODELS OF C9ORF72 - LINKED ALS/FTD.
… pathway, responsible for clearing damaged proteins and organelles, progressively declines in normal aging and in neurodegenerative diseases, leading to toxic protein aggregate accumulation. Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating …
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Regulation of SNARE function during sperm capacitation to promote the acrosome reaction
… to the World Health Organization, the male factor alone accounts for over one third of total infertility. There are various causes of male infertility but defective acrosomal exocytosis is perhaps one of the biggest contributors towards male infertility. Unfortunately there is little …
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Mutational analysis of the Vam3 transmembrane domain and its effects on vacuole fusion in Saccharomyces cerevisiae
Vam3 is a SNARE protein essential in yeast vacuole homotypic fusion. The specific role of the Vam3 trans-membrane domain (TMD) during vacuole fusion remains unclear. Previous work had shown that replacing Vam3 TMD with a prenyl lipid anchor (CCIIM) results in attenuated fusion and accumulation of …