Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"soluble CD4"”.
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Characterisation of llama antibody fragments able to act as HIV-1 entry inhibitors
… the envelope spike to the main cellular receptor CD4, allowing interaction with a co-receptor and eventually fusion of viral and cellular membranes. Neutralising antibodies inhibit HIV-1 entry by targeting epitopes on the functional spike. HIV-1 has, however, evolved several ways to evade …
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Dissociating Siv Env and Cd4: Consequenes for Virus and Host
CD4 tropism is conserved among all primate lentiviruses and likely contributes to viral pathogenesis by targeting cells that are critical for the adaptive anti-viral immune responses. Although CD4-independent variants of HIV and SIV have been described that can utilize coreceptors CCR5 or CXCR4 in …
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Single Molecule Ligand Binding Studies on CCR5 by Fluorescence Cross-Correlation Spectroscopy
… Competition binding with gp120 complexed to soluble CD4 shows that the RANTES analogues are efficient at blocking Env binding. We also show that the native chemokines are incapable of displacing the RANTES analogues from CCR5-SNAP. We speculate that CCR5-SNAP is modified differentially with …
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The screening of neutralising antibodies against a resistant HIV-1 strain to identify novel epitopes
… to monoclonal antibodies (mAbs) b12 (anti-CD4-binding site), 2G12 (anti-V3/glycan), 2F5 and 4E10 (both anti-membrane proximal external region). Of note, the virus is resistant to the extremely broad and potent mAb VRC01 (anti-CD4-bs). QH343.A10 was also found to be resistant to …
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Bedeutung des löslichen CD14-Rezeptors in Plasma und Urin als immunologischer Parameter nach Nierentransplantation und sein Verhältnis zu den löslichen Rezeptoren IL2R, CD4 und CD8
… der lösliche IL2-Rezeptor (sIL2R), der lösliche CD4 (sCD4) und der lösliche CD-8 (sCD8) ins Verhältnis mit dem sCD14 gesetzt. Es zeigt sich, dass sich die Plasmakonzentrationen des sCD14 bei Abstoßung und Infektion signifikant gegenüber einer stabilen Tx unterscheiden. Untereinander lassen sich …