Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"solid-state nanopores"”.
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Molecular Sensing with Protein and Solid-State Nanopores
… will be used in work on both a synthetic (solid-state) nanopore system and an engineered biological nanopore. I will describe the techniques for producing solid-state nanopores in thin membranes of silicon nitride and how these nanopores can be integrated into a fully functioning nanopore …
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MOLECULAR ANALYSIS OF HYALURONIC ACID (HA) USING SOLID-STATE NANOPORES
Hyaluronic acid (HA; hyaluronan) has emerged as a powerful indicator for a range of diseases and physiological conditions, including cancer, osteoarthritis, and wound healing after injury. Evidence has shown that low molecular weight HA is pro-inflammatory while high molecular weight HA is …
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Detection of Nucleic Acid Disease Biomarkers Using Solid-State Nanopores
… achieved. While this device utilizes biological nanopores, Solid-State Nanopore sensors were also initially investigated to develop sequencing devices. Significant efforts are being made to this day towards this end, with advances and improvements being made to amplifiers and using various 2-D …
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Ion transport in multilayer solid-state nanopores for memory and biosensing applications
Solid-state nanopores have emerged as powerful platforms for investigating nanoscale transport phenomena and single-molecule sensing, owing to their structural robustness, chemical stability, and ability to simultaneously probe ionic and in-plane currents during biomolecule translocation. This …
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Advanced nucleic acid detection with solid-state nanopores: from fundamental understanding to cutting-edge platforms
Solid-state glass nanopore sensing has emerged as a powerful technique for single molecule detection, due to its operational simplicity, high sensitivity, and real-time analytical capability. Despite these advantages, significant challenges remain in achieving multiplexed detection of diverse …
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Graphene supported hafnium oxide nanopores for DNA sensing
… behind personalized medicine. In this work, state-of-the-art sequencing technologies are reviewed and compared with next-generation sequencing technologies. In particular, solid-state nanopores are investigated and recent developments in the field are discussed. The interdisciplinary effort …
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Membrane transfer process for the creation of low-noise solid state nanopore devices
… multiple measurements on the same molecule. Solid state nanopores, made in free standing membranes, however, have traditionally exhibited high levels of capacitive noise at 100 kHz bandwidths, as well as poor confinement of the electric field around the nanopore. In this thesis, a novel …
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Ion transport across individual sub-continuum graphene nanopores : phenomenology, theory, and implications for industrial separations
… in particular graphene, provide a new class of solid-state nanopores - apertures that allow for the exchange of matter across thin membranes - with the smallest possible volumes of any ion channel. As the diameter of these nanopores becomes comparable to that of hydrated ions, sub-continuum …
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Solid-state nanopore sensors for nucleic acid analysis
… with subnanometer resolution. Recent advances in nanopores suggest that this low-cost, highly scalable technology could lend itself to the development of third generation DNA sequencing technologies, promising rapid and reliable sequencing of the human diploid genome for under $1000. Here, we …
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Genomics and epigenomics using 2D nanopores
… methylated DNA-MBD1 complex through 2D material nanopores under external voltage biases. The passage of the MBD1-labeled methylation site through the pore is identified by dips in the current blockage induced by the DNA strand, as well as by peaks in the transverse electronic sheet current across …
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Applications of nanopore sensing and DNA nanotechnology for the analysis of nucleic acids
… resistive pulse sensing. It includes biological nanopores, primarily used for long-read direct sequencing, and solid-state nanopores, which have been applied to biosensing molecules such as proteins, RNA, and DNA. While solid-state nanopores hold immense promise for sensing applications beyond …
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DNA translocation through an array of kinked nanopores
Synthetic solid-state nanopores are being intensively investigated as single-molecule sensors for detection and characterization of DNA, RNA, and proteins. This field has been inspired by the exquisite selectivity and flux demonstrated by natural biological channels and the dream of emulating these …
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Improving the Signal-to-Noise of Nanopore Sensors
Over the last five years, solid state nanopore technology advanced to rival biological pores as a platform for next generation DNA sequencing. Fabrication improvements led to a reduction in nanopore diameter and membrane thickness, offering high precision sensing. Custom electronics were developed …
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Nanopores for detecting and sensing biological molecules
… molecules (DNA, proteins, aminoacids, etc.) with solid-state nanopores, atomically-resolved scanning and detection of these molecules remains a significant challenge. In most nanopore-based DNA sequencing and single molecule detection techniques, ionic current blockade and blockade duration are …
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Tip-based nanolithography and application to molybdenum disulfide devices
… Finally, this work demonstrated DNA sensing with solid state nanopores integrated with monolayer MoS2 nanoribbon transistors. Nanopores of 4-10 nm were drilled in ~ 100 nm wide hBN encapsulated monolayer MoS2 nanoribbons. Translocation of 3kbp dsDNA through a monolayer MoS2 nanoribbon-nanopore …
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Single-Molecule Characterization of RNA via Nanopore Sensing
… of interest, followed by characterization via solid-state nanopore sensing. I first describe the nanopore observables and nucleic acid parameters relevant to nanostructure characterization. Then, I demonstrate how tandem implementation of nanostructure engineering and nanopore sensing can be …
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Drug discovery for misfolding diseases using structure-based iterative learning
… species. The approach is based on the use of solid state nanopores and multiplexed DNA barcoding to identify and characterise oligomers from multiple samples. I study α-synuclein oligomers in the presence of several small molecule inhibitors of α-synuclein aggregation, as an illustration of …