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Showing 1 to 2 of 2 for “"solid-phase strategy"”.
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Studies on Solid-Phase Peptide Synthesis: The Synthesis of Glucagon
<p>The feasibility of the stepwise-solid phase approach was studied in the synthesis of the peptide hormone glucagon. The choice of this molecule was based upon: (1) the unusual chemical structure; (2) biological significance. The main features of the strategy employed are: (1) the use of …
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Insights into the Synthesis, Mechanism of Action, and Biosynthesis of a Novel Lipodepsipeptide Antibiotic, WAP-8294A2
… the biosynthetic machinery.</p><p>We developed a solid-phase strategy for the development of WAP-8294A2 and analogs with on-resin cyclization based on molecular modeling studies. We chose a macrocyclization site between Glu8 and Asn9 to take advantage of a predicted turn element and used the …