Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 219 for “"solid tumors"”.
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Drug Delivery to Solid Tumors via Polymeric Nanoparticles
A main challenge in chemotherapy is to deliver an anti-cancer drug selectively to tumor and avoid off-target exposure to other body tissues and organs. Nanoparticles (NPs) have been considered a promising approach for tumor drug delivery, with popularity attributable to the famous “Enhanced …
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Engineering antibodies for improved targeting of solid tumors
… antigens. Unfortunately, attempts to treat solid tumors with these drugs are often limited by an inability of the antibodies to fully penetrate the tumor tissue, leaving large regions of untargeted and viable cells. The goal of this thesis is to understand the transport phenomena that …
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Quantitative analysis of perivascular antibody distribution in solid tumors
… that have shown efficacy in a range of blood and solid tumors. Antibodies targeting solid tumors face considerable transport barriers in vivo, including blood clearance, extravasation, diffusion within the tumor interstitium, binding to antigen, endocytosis, and degradation. The unique pathology …
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Functions of connexin 46 in lens and solid tumors during hypoxia
… Cx46 expression is modulated in breast and bone tumors, and during ischemia. It is hypothesized that Cx46 provides resistance to hypoxia mediated cell death by prolonging survival. In this study, Cx46 expression was detected in human Y79 retinoblastoma cells. Decreasing the expression of Cx46 in …
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Development of an IL12 Prodrug to Treat Solid Tumors with Minimal Toxicity
… dose pro-IL12 more effectively controls large tumors at the cost of reintroducing systemic toxicity. Mechanistically, this dose used a broader, T cell-dependent mechanism that was independent of IFNγ. Further analysis determined that IFNγ was responsible for all manifestations of toxicity and …
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Cytotoxic T cell function in solid tumors: principles and implications for immunotherapy
Contains fulltext : 145309.pdf (Publisher’s version ) (Open Access)
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Development and Characterization of B7-H3-Targeted Radioimmunotherapies For The Treatment of Solid Tumors
… as non-Hodgkin’s Lymphoma. However, treatment of solid tumors by radioimmunotherapy remains a challenge, driven in part by a lack of high affinity antibodies against highly tumor-selective surface antigens. Herein, we characterize novel<sup> </sup>anti-B7-H3 immuno-conjugates for PET imaging and …
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Preclinical Evaluation of a Novel Polysaccharide Hydrogel for Local Chemotherapy Delivery to Solid Tumors
… Glioma was chosen for its ability to form solid tumors in a rodent flank model, its aggressive malignancy, and its resistance to treatment. AD 198 was incorporated into the hydrogel during synthesis. Mechanical testing of the polymer network revealed that there was no change in hydrogel …
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The role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors
… injected into NUDE mice formed smaller tumors due to a higher percentage of apoptotic cells. In other tissues Bcl-3 has been shown to regulate proliferation through expression of its target gene CYCLIN D1, a process that is negatively regulated by CYLD. We found that CYLD knockout MEF …
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Identification of the presence and activity of the JAK-STAT pathway in canine solid tumors
… of the JAK-STAT pathway in selected canine tumors. Methods: Formalin-fixed, paraffin-embedded samples from mast cell tumors (MCT), hemangiosarcomas (HSA), thyroid carcinomas, and apocrine gland anal sac adenocarcinomas (AGASACA) were obtained from the Diagnostic Histopathology Laboratory at …
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An examination of the relationship between epithelial to mesenchymal transition and cancer stem cells in solid tumors
… transition (EMT) and cancer stem cells (CSC) in solid tumors. Epithelial to mesenchymal transition describes the conversion of cancer cells from an adherent, differentiated, and polar phenotype (epithelial) to a motile, plastic, and apolar phenotype (mesenchymal). EMT is correlated with …
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Study on interactions of new anticancer drugs and their utilization for modulation of multidrug resistance in solid tumors
… a jejich využití pro modulaci multirezistence u solidních nádorů V posledních letech vedly nové cílené terapie k zásadním průlomům v léčbě nádorových onemocnění. Navzdory tomuto vývoji zůstávají nádory druhou nejčastější příčinou úmrtí na celém světě, přičemž část této vysoké úmrtnosti je …
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Study of Dosimetric and Thermal Properties of a Newly Developed Thermo-brachytherapy Seed for Treatment of Solid Tumors
Studies on the curative effects of hyperthermia and radiation therapy on treatment of cancer show strong evidence of synergistic enhancement when both radiation and hyperthermia treatment modalities are applied simultaneously. A variety of tissue heating approaches developed to date still fail to …
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Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors
Recent advancements in pharmaceutical technology based on principles of nanotechnology, polymer chemistry, and biomedical engineering have resulted in the creation of novel drug delivery systems with the potential to revolutionize current strategies in cancer chemotherapy. In oncology, realization …
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Advancing T Cell–Based Immunotherapies: Identification of Tumor-Specific T Cell Receptor Targets and Mechanisms of Resistance in Solid Tumors
… success in hematologic malignancies and several solid tumors, most patients with solid tumors either fail to respond or eventually relapse. This limited efficacy is partly due to the absence of optimal target antigens and the development of tumor-intrinsic immune resistance mechanisms that enable …
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Inhibition of adenosinergic signaling in the tumor immune environment: the effect of combination CD73 blockade and oHSV therapy on solid tumors
… responses. Transcriptomic analysis of patient tumors pre- and post-virotherapy with CAN-3110 revealed increased expression of the adenosine receptor gene <em>ADORA2B </em>after treatment. The accumulation of eADO in the TME is predominantly the responsibility of ectoenzyme CD73 (<em>NT5E</em>) …
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Evaluation of the Pharmacokinetic-Pharmacodynamic relationship, Metabolism and Plasma Protein Binding of the novel antitumor agent, 2-Methoxyestradiol (2ME2), following oral administration in patients with solid tumors.
… and pharmacokinetics of 2ME2 in patients with solid tumors and determine maximum tolerated dose (MTD). The following hypotheses were tested: 1) 2ME2 will be well tolerated in clinic when given orally and will have quantifiable effects on the ex vivo markers of angiogenesis and apoptosis; 2) …
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