Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"solid tumor"”.
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The Roles of Malt1 In Nf-Κb Activation and Solid Tumor Progression
… it has been suggested thatNF-κB is critical in tumorigenesis and tumor progression, the molecular mechanism by which NF-κB is activated in solid tumor remains largely unknown. In the current work, we focus on growth factor receptor-induced NF-κB activation and tumor progression, including …
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Engineering VHH-based chimeric antigen receptor (CAR) T cell therapy for solid tumor treatment
… but have experienced low efficacy against solid tumors for a number of reasons, including a paucity of tumor-specific antigens to target and a highly immunosuppressive solid tumor microenvironment. In chapter 2 of this thesis, we develop a strategy to target multiple solid tumor types …
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Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth
… promising applications in drug delivery to solid tumors and bottom-up synthesis and integration of nanodevices. This thesis presents a novel multistage nanoparticle delivery system consisting of an assembly of nanoparticles that can change its size to facilitate transport into solid tumors. …
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Unraveling The Effects of Aerobic Exercise and Erk5 Signaling In The Solid Tumor Microenvironment Using Murine Models
<p>Solid tumors are comprised of multiple cell types which communicate and work together to promote tumor progression. Advances in the treatment of solid tumors have armed clinicians with more efficacious pharmacologic agents and combinations. However, a focus on drug adjuvants in the treatment of …
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Mechanisms Underlying The Heterogeneous Sensitivities of Cancer Cells to Proteasome Inhibitors
… inhibitors have not been clearly elucidated in solid tumor models. Evidence suggests that the ability of a cell to manage the amount of proteotoxic stress following proteasome inhibition dictates survival. In this study using the FDA-approved proteasome inhibitor bortezomib (Velcade®) in solid …
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Neuroblastoma: A Theoretical Dose Dependent Study With Therapeutic Implications
… is the most prevalent extracranial childhood solid tumor with several stages of disease. While many children have an aggressive metastatic form of the disease, spontaneous regression has also been well documented. Individualized treatments are required due to the spectrum of disease staging, …
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Layer-by-Layer Nanoparticles for Targeted Delivery and Treatment of Ovarian Cancer
… of nodal lesions, complete surgical removal of solid tumor may be impossible. Adjuvant chemotherapy is often associated with significant dose-limiting systemic toxicities, and can lead to platinum-resistant disease. To date, there are no FDA-approved therapies that significantly prolong the …
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The Use of High-Affinity T Cell Receptors to Study Specificity in the 2C T Cell System
… the detection and diagnosis of specific virus or tumor antigens (peptide-MHC) on the cell surface. In addition, the TCRs would provide a useful probe for tracking the processing and presentation of specific antigens. Chapter 6 discusses the development of soluble single-chain TCRs with enhanced …
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CHARACTERIZATION OF THE RNA BINDING MODE OF A PLATINUM-ACRIDINE AGENT
… agent that shows activity in a broad range of solid tumor cell lines. Unlike the classical platinum-based cross-linking drugs, this agent produces its cytotoxic effect by two synergistic DNA binding mechanisms: monofunctional platination and intercalation of the acridine chromophore. The RNA …
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Improving surgical documentation in paediatric oncology evaluating the outcomes of synoptic operative reports on documentation completeness in childhood cancer surgery
… of critical intraoperative findings in pediatric solid tumor resections. By developing evidence-based guidelines for surgical documentation in pediatric oncology, this work aims to identify universal critical intraoperative findings that should be documented, provide practical recommendations for …
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EXPLORING HETEROSTRUCTURED UPCONVERSION NANOPARTICLES: FROM RATIONAL PARTICLE ENGINEERING TO BIOMEDICAL APPLICATIONS
… but also has a poor drug distribution inside solid tumors whose interiors are poorly vascularized. To resolve the above issues, firstly, asymmetric silica-coated UCNPs were prepared with tunable silica coverage ratio and morphology. On one hand, through stepwise passivation on the asymmetric …
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INTRA-TUMORAL INFILTRATION OF GZMKHIGH CD8+ T EFFECTOR MEMORY CELLS IS ASSOCIATED WITH POOR CLINICAL OUTCOME IN NON-METASTATIC COLORECTAL CANCER.
As with most solid tumor malignancies, CRC possess more than one major histological subtype that likely generate disparate immune responses. The heterogeneity in the immune cell response to CRC highlights the need to develop novel immune diagnostics that could predict the risk of disease relapse …
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A novel nanodelivery system for combination tumor therapy
… alone have not proven effective in inducing tumor regression in the clinic due to both the cytostatic nature of anti-angiogenic therapy and the potential formation of new regions of hypoxia within the tumor after therapy. The new therapeutic paradigm is for combining both anti-angiogenics and …
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Nuclear magnetic resonance sensors and methods for chemical sensing in tissue
… range of medical fields including trauma, solid tumor cancers, tissue grafts, wound healing, dehydration, athletic performance, and congestive heart failure. Nuclear magnetic resonance (NMR) offers a non-ionizing, rapid, repeatable, and molecularly sensitive measurement technique for …
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Compressive stress enhances coordinated migration of mammary carcinoma cells
… on genetic and biochemical changes during tumor progression. Uncontrolled cell proliferation of a solid tumor in a confined space not only creates well-studied oxidative stress (hypoxia), but also generates growth-induced mechanical stress (compression). However, the importance of such …
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Tumor Angiogenesis is all Tied up in Tie2-Expressing Macrophages
The impact of the immune system on solid tumor formation and malignant disease has been the focus of much study over the last several decades. Elimination of macrophages from mouse models for malignancy result in decreased in tumor angiogenesis, progression and malignancy. Further migration of …
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β‘-hidroksi- arba α-pakeistų enonų sintezės metodų kūrimas ir susintetintų junginių struktūros - priešvėžinio aktyvumo sąryšio įvertinimas /
… remarkable antiproliferative activities in human solid tumor cell lines. In this concept, the main aim of the present work was dedicated to the development of synthetic approaches of these two main structural scaffolds together with their structure-anticancer activity relationship evaluation. It …
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Colon Cancer Initiation and Progression
… Given that a common early perturbation in solid tumor initiation is bypass of matrix-dependent proliferation restraints we sought to functionally interrogate candidate colorectal cancer genes (CAN-genes) to identify driver tumor-suppressors. We have developed an isogenic human colonic …
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Implementation and Cost Analysis of Performing Molecular Assays using FFPE Tissue Blocks in the Clinical Laboratory at VA Palo Alto Health Care System
… KRAS and EGFR- as a starting point to bring solid tumor oncology testing at the clinical laboratory at VA PAHCS.</p> <p>The project’s overall design was broken down according to the following activities: (1) Lay out an implementation plan, (2) Conduct thorough market research, (3) Perform …
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