Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"solid support"”.
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Modification of Lipid Microenvironments on Solid Support Structures for Use in Transmembrane Protein Assays
… These lipid formulations, when fused with solid silica support structures such as planar surfaces or silica microbeads, allows for the reconstitution of the three of proteins of interest.</p> <p>These assay and high throughput platforms are essential to understanding key functions and …
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Part I. Cleavage of Carbamates to Isocyanates: Selectivity, Extension to the Solid Support, and Synthesis of Multivalent Glycoforms With Inter-Saccharide Carbamate Linkages. Part II. Conjugation of Carbohydrate Moieties to a Rigid Aromatic Linker for the Study of Glycoside Internal Dynamics
Part II. A synthetic protocol for the synthesis of carbohydrate-linker moieties that will allow conjugation of a saccharide to a protein is reported. This approach was demonstrated in the synthesis of the saccharide-linker moieties of the four glucopyranosyl-beta-D-glucopyranosides. The results …
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Graphene-Supported Metal Nanoparticles For Applications in Heterogeneous Catalysis
… has become a good candidate as an effective solid support for metal catalysts. The Nobel Prize in Physics for 2010 was awarded to Andre Geim and Konstantin Novoselov "for groundbreaking experiments regarding the two-dimensional material graphene". Microwave-assisted synthesis of various …
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DESIGN OF A SCREENING PROCESS FOR THE DEVELOPMENT
… design a library of small molecules on the same solid support surface. This solid support surface, and the chemistry involved, can be utilized as a means of developing lead target molecules, namely ligands and catalysts. Evidence shows the successful assembly of both simple amino acids, as well …
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Nucleoside and oligonucleotide approaches towards potential HIV chemotherapies
… Arakyl-substituted oligonucleotides were made by solid phase synthesis using either the appropriate aralkyl-substituted phosphoramidite or by post-synthetic substitution of a pentafluorophenoxy substituent by N-methylphenethylamine. The presence of phenethyl or benzoyl substituents invariably …
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Solid Phase Synthesis of M-Phenylene Ethynylene Oligomer Heterosequences
… process. To address this, two methods for the solid-phase synthesis of mPE oligomers (including heterosequences) have been developed. The first strategy employs a silyl-acetylene linker attached to ArgoGel(TM) solid support, and uses palladium-catalyzed cross-coupling reactions to form the …
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Supporting Well-Defined Platinum Group Metals in Metal-Organic Frameworks for Heterogeneous Catalysis
… (and thus their high selectivity/activity) to a solid support. In this thesis, I describe the development of methodologies for producing well-defined single-site PGM catalysts on a solid support using metal-organic frameworks (MOFs). MOFs are attractive platforms for the heterogenization of PGM …
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Multiplexed genotyping of single nucleotide polymorphisms using microarray technology
… study was initiated to adapt minisequencing to solid support to interrogate multiple SNPs which had been reported to be associated with coronary artery disease. This microarray-based platform has demonstrated a great potential for highly parallel genotyping. Secondly, an innovative two-color …
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CONSTRUCTING NANOSTRUCTURES WITH ATOMIC PRECISION: THE SYNTHESIS OF SPIROLIGOMER-BASED MACROCYCLES
… to highly functionalized spiroligomers on solid support has been developed that results in increased yields relative to previously published methods. This new approach makes use of a protecting group, para-nitrobenzyl carbamate, which has not previously been incorporated in bis-amino acids …
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The Study of Lanthanides for Organometallic and Separations Chemistry
… These calix[4]arenes will be attached to a solid support through an alkyl linker at the methylene position and separation will be based primarily on the ionic radius of the metal cation. </p><p>In summary, we report the synthesis and derivatization of a series of …
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Synthesis and characterization of polyamidoamine dendrons
… AMido AMine (PAMAM) dendrons using silica gel as support and characterize them. PAMAM dendron, a hyperbranch of the PAMAM dendrimer, was divergently synthesized on solid support. Prior to the propagation through (1) Michael addition of acryl ester to an amino reactive site of the organic phase …
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Adsorption, encapsulated solute leakage and microflow of giant vesicles during anhydrobiotic preservation in trehalose solutions
… typically dried in carbohydrate solutions on a solid support, there are few studies on the role played by the support. This work seeks to help remedy such deficiencies. First, considering damage mechanisms at the individual cell level, giant liposomes were employed as a model cell system, given …
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Asymmetrische Synthese Delta 3a,4 -ungesättigter bicyclischer Prolin-Analoga und Festphasensynthese mit vinylischen Sulfoximinen
… of at least four different compounds remained on solid support after three steps and it was impossible to calculate the equivalents of reagents used in the next transformation accurately. At this point the project was stopped. In a second approach (+)-(aS,SS)-(S-(4-tert-butyl-cyclohexylidene …
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The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography
… a precursor to the desired radiotracer on a solid support which is cleaved on exposure to [18F]-fluoride ion to give the 18F-labelled radiotracer in solution. The RLV methodology allows for easier purification of the 18F-labelled radiotracer as a simple filtration step removes the unreacted …
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Innovative Methods for Biomass Sugars Utilization
… method, urease and XI were co-immobilized on a solid support to produce a high pH microenvironment within a low pH bulk fermentation media to implement simultaneous isomerization and fermentation (SIF) of ethanol by native yeast. Several water-soluble complexing agents were tested for their …
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Algorithms for improving the design and production of oligonucleotide microarrays
… or synthesized at specific locations of a solid support. Probes are built, nucleotide-by-nucleotide, by a light-directed combinatorial chemistry. Because of the natural properties of light, the quality of a microarray can be compromised if the physical arrangement of the probes on the array …
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BINOL-Catalyzed Asymmetric Synthesis of Chiral Heterocycles; Experimental Mechanistic Study of Binol-Catalyzed Conjugate Addition of Vinylboronic Acids to Enones; Enantioselective Synthesis of Diarylalkane Compounds via Binol-Catalyzed Conjugate Addition
… on the reaction rate. The results provided solid support for the proposal mentioned above. Work in our laboratory showed that heteroaryltrifluoroborates exhibited superior reactivity to boronic acids in the synthesis of chiral bis-heterocycles. Therefore, in the latest project, we made use …
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Personalization And Increased Engagement Through Extended Learning Opportunities
… of the program for students. The study provides solid support for the growth and expansion of the ELO program at Hillsboro-Deering High School.</p>
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Celulases para produção de etanol de segunda geração
… Immobilization is the enzyme confinement in a solid support for reuse of the biocatalyst.
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Synthesis of bespoke matrices to investigate a novel anti-tumour molecular target using affinity chromatography. The design, synthesis and evaluation of biotinylated biarylheterocycles used as novel affinity probes in the identification of anti-tumour molecular targets.
… in which test compounds were attached to a solid support through a biotin tag. A synthetic route to hit compounds containing a biotin moiety in place of one of the imidazole sidechains was developed. Chemosensitivity studies confirmed that the biotinylated compounds retained their activity …
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