Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"sol-gel transition"”.
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Structure and Dynamics of Polymers: From Bulk Solutions to Single Polymer Translocation
… chapters. Chapter 2 studies the critical phase transition in ternary polymer solutions. Chapter 3 studies the sol-gel transition of triblock copolymers. Chapter 4 and 5 investigate the translocation of a single polymer through a nanopore, focusing on the polymer translocation dynamics under …
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Synthesis and characterization of pH/temperature dual sensitive multiblock copolymer for drug delivery
… temperature/pH dual-sensitivity which undergoes gelation at body temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal linker, 2,2-bis(aminoethoxy)propane …
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Self-assembling silk hydrogels for mesenchymal stem cell and drug delivery
… for tissue engineering and silk fibroin hydrogels containing silk nanoparticles have previously been studied for the controlled delivery of model drugs. The aims of this thesis was to characterise silk hydrogels by both FT-IR analysis and using compression testing. Next, the effect of loading …
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Development of environmentally benign microencapsulation with polymer microspheres and liposomes
… feature reduction/prevention of using organic solvents, making them particularly attractive as green technology. For polymer microencapsulation, a novel in situ polymerization based process to encapsulate various types of fine particles, include drugs, fire retardant, inorganic nanoparticles, …
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Single molecule studies of polymers and self-assembling materials: Effects of chain topology and entanglements
Understanding the dynamics of polymer solutions and functional materials in nonequilibrium flow conditions is of key importance for controlling materials properties during processing, which often involves highly nonequilibrium states that cannot be understood in terms of equilibrium principles or …
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Design of Thermosensitive Hydrogel for Extended-Release of Praziquantel
… develop an extended-release thermosensitive hydrogel formulation that was applicable to the injectable administration. The praziquantel-loaded hydrogel formulation based on poloxamer 407 (20%, w/v) was prepared, and two strategies for modifications of poloxamer 407 hydrogel were studied. One of …
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Smart Hydrogels based on Responsive Star-Block Copolymers
… copolymers and their formation of smart hydrogels in response to different external stimuli, specifically temperature and pH. Our concept was based on (AB)x diblock copolymer stars where both blocks are responsive to temperature and pH. This approach led to physically crosslinked hydrogels, …
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Development of Topical Ophthalmic In Situ Gel-Forming Estradiol Delivery System Intended for the Prevention of Age-Related Cataracts
… that an ophthalmic estradiol in situ gel-forming formulation would be more effective for inducing lenticular estrogen responses without undesired uterine stimulation associated with systemic delivery. The following aims tested this hypothesis: 1) to develop an ophthalmic in situ …
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Expression of cysteine-rich pig gastric mucin (Muc5AC) domains in Pichia pastoris and their pH-dependent properties
… Pig gastric mucin (PGM) forms a viscoelastic gel exhibiting a sol-gel transition at the low pHs found in the stomach. Our laboratory has demonstrated that the non-glycosylated cysteine-rich (Cys-rich) regions of the protein core of PGM play important roles in the hydrophobic, electrostatic and …
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"Smart" Hydrogels based on Trishydrophilic Triblock Terpolymers
… utilization for the construction of “smart” hydrogel systems, responding to a variety of external stimuli. The central focus was put on ABC triblock terpolymers composed of a pH-sensitive A block, a water soluble B block and a thermo-sensitive or multi-responsive C block. This concept was used for …
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Synthesis and characterization of thermosensitive hydrogels derived from polysaccharides
In this work, thermosensitive hydrogels having tunable thermo-mechanical properties were synthesized. Generally the thermal transition of thermosensitive hydrogels is based on either a lower critical solution temperature (LCST) or critical micelle concentration/ temperature (CMC/ CMT). The …
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Chemical amplification in self-stiffening materials
… stimulus. Decoupling these two reactions largely simplifies requirements of synthesizing specific and sometimes complex functionality for sensitive response and allows for myriad combinations of reactions. In Chapter 2, an organic acid amplifier was first used to amplify a below-threshold …
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Synthesis, characterization, and biological evaluation of gelatin-based scaffolds
… work presents the development of entropy-elastic gelatin based networks in the form of films or scaffolds. The materials have good prospects for biomedical applications, especially in the context of bone regeneration. Entropy-elastic gelatin based hydrogel films with varying crosslinking densities …
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Investigating Ageing of Neurodegenerative Disease Relevant Protein Condensates
… properties change, from a liquid state to a more gel-like or solid-like state. This process is referred to as a solution-to-gel (sol-gel) transition. There are many external factors leading to this property change, such as temperature and stress. There has been as yet no systematic examination of …
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Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
… the macromolecule embedded thermosensitive gels or nanoparticles (NPs) or composite nanoformulation (NPs suspended in gel) for a sustained drug delivery. PBG (PLA-PCL-PEG-PCL-PLA; PBG-1 and PEG-PCL-PLA-PCL-PEG; PBG-2) gelling copolymers were evaluated for their utility as injectable in situ …
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Design of biopolymer-based networks with defined molecular architecture
… work, the synthesis of biopolymer-based hydrogel networks with defined architecture is presented. In order to obtain materials with defined properties, the chemoselective copper-catalyzed azide-alkyne cycloaddition (or Click Chemistry) was used for the synthesis of gelatin-based hydrogels. …
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Capturing Complex Microenvironments for Directed Stem Cell Differentiation
… associated with these events are still largely unknown. Further, the development of mature vascular phenotypes, such as vascular smooth muscle cells (vSMCs), with functional behavior remains elusive to the research community. This thesis proposed to engineer and direct specific and mature …
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Chitosan/Ellagic Acid Composite Materials for Local Cancer Therapy
… were developed by combining 1% (w/v) chitosan solution with different concentrations (0.05, 0.1, 0.5, 1, or 20% (w/v)) of ellagic acid for a local chemotherapy. Characterization of composite films was performed on chemical structure, crystallinity, surface morphology, degradation behavior, and …