Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"soft tissue sarcomas"”.
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Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs with Spontaneously Occurring Soft Tissue Sarcomas
… that causes mechanical fragmentation of tissue, resulting in liquefied acellular debris with histologically clear demarcated boundaries between treated and non-treated tissues. The acellular debris may include tumor antigens with preserved immunogenicity and the potential to generate …
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Investigations of Ultrasound-Guided Histotripsy Ablation for Soft Tissue Sarcomas, Osteosarcomas, and Brain Tumors
… acoustic cavitation to mechanically disintegrate tissue into an acellular homogenate. Histotripsy applies microsecond-length, high pressure (> 10 MPa) pulses to initiate the rapid expansion and collapse of nuclei in a millimeter-scale focal region, applying large stresses and strains to targeted …
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Second cancers following treatment for retinoblastoma
… developing additional cancers, mostly bone and soft tissue sarcomas and melanoma. Despite advances in understanding of second cancer risks following treatment for retinoblastoma, key research questions remained including 1) risks of common adult onset cancers, some of which have somatic …
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A novel approach to the clinical diagnosis and treatment of canine histiocytic sarcoma
… Given the poor prognosis of HS compared to other soft tissue sarcomas in dogs, the research performed focuses on diagnosis including immunohistochemistry (IHC), the use of a combination treatment protocol in cell culture, and potential use of serum biomarkers in monitoring response to treatment. …
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Molecular basis of immunotolerance in canine neoplasia
… molecules by the cancer cells. In contrast, soft tissue sarcomas are poorly immunogenic, as Tumor infiltrating Lymphocytes are lacking, or when present they are usually at the periphery of the tumor. Still, soft tissue sarcomas are considered immunosuppressed. Checkpoint molecules from the …
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High-Resolution Array Comparative Genomic Hybridization Identifies Common Targets in Rhabdomyosarcoma
… (RMS) accounts for nearly 50 percent of the soft tissue sarcomas that affect children. There are two major histological variants, alveolar (ARMS) and embryonal (ERMS). Both are defined as sarcomas that show exclusive evidence of muscle differentiation, but differ in their pathogenesis and …
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Attitudes and Practices of Genetic Counselors In Providing Predictive Testing to Minors At Risk For Li-Fraumeni Syndrome
… variety of cancers, including breast cancer, soft tissue sarcomas, osteosarcomas, brain tumors, and adrenocortical carcinomas. Individuals found to carry germline mutations in <em>TP53</em> have a 90% lifetime cancer risk, with a 20% chance to develop cancer under the age of 20. Despite the …
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Clinical and Biological Patterns in Soft Tissue Sarcoma
Soft tissue sarcomas (STSs) are rare malignant tumors, of which 3/4 are high-grade and 1/3 metastasize. For optimal management, STSs should be treated at multidisciplinary sarcoma centers. Study I demonstrated that simple referral guidelines, an open-access outpatient clinic and repeated educative …
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The role of PAX3/PAX7-FKHR in mesenchymal stem cell myogenic differentiation and rhabdomyosarcomagenesis
Rhabdomyosarcomas are soft tissue sarcomas (STS) that, while extremely rare in adults, are one of the most common neoplasms in children and adolescents. Rhabdomyosarcomas are presumed to be associated with the skeletal muscle lineage, although surprisingly, those tumors can be present in organs …
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Genetic Profiling in Soft Tissue Sarcoma
Soft tissue sarcomas (STS) are a heterogeneous group of highly malignant mesenchymal tumors that account for ~1% of all malignancies. Frequent heterogeneity and pleomorphism along with suboptimal diagnostic reproducibility and insufficient prognostic markers make clinical management of these tumors …
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Temozolomide and Bevacizumab Therapy In Advanced Hemangiopericytoma/ Solitary Fibrous Tumor
… from fibroblasts and represent a small subset of soft tissue sarcomas. Surgery is typically the treatment of choice for localized disease, with reported 10-year overall survival rates of 54-89% after complete surgical resection. However, for the approximately 20% of HPC/SFT patients who eventually …
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Multiomic Analyses Reveal Epigenomic Alterations and New Targets of Polycomb Repressive Complex 2 in Schwann Lineage Cells and Malignant Peripheral Nerve Sheath Tumors
… nerve sheath tumors (MPNST) are lethal soft tissue sarcomas occurring in 5-13% of Neurofibromatosis Type I (NF1) patients. It is thought that MPNSTs develop from benign precursors. However, the existing histologically defined stages in MPNST development need improvement. Commonly, MPNSTs …
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Extending Space-Time Putative Hazard Models to Detect Latent Risk Features
… jointly Non-Hodgkin's lymphoma (NHL) and soft tissue sarcomas (STS) cancers.</p>
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Role of the RING domain in MDM2-mediated ubiquitination of p53
… throughout many cancer types, including 30% of soft tissue sarcomas. Dissecting the mechanism of MDM2 function is an important step in identifying specific drugable interfaces on MDM2 and its interacting partners so that effective therapeutics can be designed.
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pRb's role in cell fate, lineage commitment, and tumorigenesis
… have addressed this issue in the context of bone sarcomas, a tumor type in which pRB is frequently inactivated. To model osteosarcoma in the mouse we used a targeted conditional approach in which Rb and/or p53 were deleted in pre-osteoblasts or mesenchymal stem cells. In osteoblasts we found that …
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USE OF NEAR-INFRARED FLUORESCENCE WITH INDOCYANINE GREEN IN SMALL ANIMAL SURGICAL ONCOLOGY AND IN CADAVERIC ANATOMICAL STUDY
… that enables real-time visualization of tissue perfusion and lymphatic structures through the use of fluorescent dyes such as indocyanine green (ICG). Although well-established in human surgery, its clinical application in veterinary surgical oncology is still developing. In recent years, …
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Soft Tissue Sarcoma Patterns multiplicity, heterogeneity and growth characteristics
Soft tissue sarcomas (STS) represent a group of rare and heterogenous tumors that optimally should be diagnosed and treated within multidisciplinary teams. This thesis has studied various aspects ? pathological, genetical, and clinical ? of STS. In study I, we demonstrated that 20% of the patients …
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Determining the Oncological and Immunological Effects of Histotripsy for Tumor Ablation
… a tumor to mechanically fractionate targeted tissues. While pre-clinical work has demonstrated the feasibility of applying histotripsy to solid tumors including primary liver and renal tumors, there is still a need to investigate the potential of histotripsy to treat additional malignancies. …
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NEW INSIGHTS INTO PATHOGENESIS AND PROGNOSIS OF CANINE SARCOMAS
The majority of canine soft tissue and visceral sarcoma prognostic studies have been influenced by a “one size fits all” approach which lead researchers to merge different subtypes of sarcomas in the same study population. The consequent heterogeneity of cases hampered the interpretation of the …
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