Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"soft tissue sarcoma"”.
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Genetic Profiling in Soft Tissue Sarcoma
Soft tissue sarcomas (STS) are a heterogeneous group of highly malignant mesenchymal tumors that account for ~1% of all malignancies. Frequent heterogeneity and pleomorphism along with suboptimal diagnostic reproducibility and insufficient prognostic markers make clinical management of these tumors …
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Clinical and Biological Patterns in Soft Tissue Sarcoma
Soft tissue sarcomas (STSs) are rare malignant tumors, of which 3/4 are high-grade and 1/3 metastasize. For optimal management, STSs should be treated at multidisciplinary sarcoma centers. Study I demonstrated that simple referral guidelines, an open-access outpatient clinic and repeated educative …
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Soft Tissue Sarcoma Patterns multiplicity, heterogeneity and growth characteristics
Soft tissue sarcomas (STS) represent a group of rare and heterogenous tumors that optimally should be diagnosed and treated within multidisciplinary teams. This thesis has studied various aspects ? pathological, genetical, and clinical ? of STS. In study I, we demonstrated that 20% of the patients …
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Targeting Histone Deacetylases (Hdac) For The Treatment of Soft Tissue Sarcoma
… of genetically complex soft tissue sarcoma</strong></p> <p>Histone deactylase inhibitors (HDACi) are a new class of anticancer therapeutics; however, little is known about HDACi or the individual contribution of HDAC isoform activity in soft tissue sarcoma (STS). We …
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Dissecting the Role of ATRX in Soft Tissue Sarcoma Development and Therapeutic Response
… is one of the most frequently altered genes in soft tissue sarcoma, with alterations occurring in 29% of these tumors. However, the role of ATRX in the development and response to cancer therapies in soft tissue sarcoma remains poorly understood. Here, we developed a primary mouse model of soft …
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Pretreatment Tumor Sampling and Prognostic Factors in Patients with Soft Tissue Sarcoma of the Head and Neck
Tutkimuksen aiheena oli pään ja kaulan alueen pehmytkudossarkoomapotilaiden hoitoa edeltävän näytteenoton merkitys potilaiden toipumiseen ja selvittää, mitkä olivat tärkeimmät ennustetekijät potilaiden selviytymisen kannalta. Sarkoomat ovat heterogeeninen joukko harvinaisia pahanlaatuisia …
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Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence.
In adult soft tissue sarcoma (STS) of the extremities and trunk wall, improved prognostic factors are needed to identify patients at high-risk for metastasis. Various factors are included in the many prognostic systems currently in use and the prognostic value of immunohistochemical (IHC) …
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Molecular basis of immunotolerance in canine neoplasia
… molecules by the cancer cells. In contrast, soft tissue sarcomas are poorly immunogenic, as Tumor infiltrating Lymphocytes are lacking, or when present they are usually at the periphery of the tumor. Still, soft tissue sarcomas are considered immunosuppressed. Checkpoint molecules from the …
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ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… and immunocytokine therapies, especially in soft tissue sarcoma, AGASAC, and melanoma. KIT and PDGFR-β show potential for diagnosis and targeted treatment in sarcomas and AGASAC, while OXTR represents an innovative area for further research. The observed heterogeneity of target expression …
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Modeling Renal Anomalies Associated with Li-Fraumeni Patients: A Novel Role for p53 in Kidney Development
… to various types of cancers, including osteosarcoma, soft tissue sarcoma, acute leukemia, and adrenal cortical tumors, as well as breast and brain cancer. Additionally, these patients have an increased risk of developing kidney, stomach, colon, pancreas, esophagus, lung, and gonadal germ cell …
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Identification of transcriptional mechanisms downstream of nf1 gene defeciency in malignant peripheral nerve sheath tumors
… nerve sheath tumor (MPNST) is a type of soft tissue sarcoma that occurs in carriers of mutations in the neurofibromatosis type I gene (Nf1) as well as sporadically. Plexiform neurofibromas in NF1 patients have a significant risk of developing into MPNSTs leading to increased morbidity and …
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Risk of Subsequent Neoplasms During the Fifth and Sixth Decades of Life in the Childhood Cancer Survivor Study Cohort
… renal cancer (SIR=3.9, 95% CI 2.0-7.5), soft tissue sarcoma (SIR=2.6, 95% CI 1.5-4.4), and thyroid cancer (SIR=1.9, 95% CI 1.0-3.5). Female sex (RR=1.9, 95% CI 1.3-2.6, P<0.001) and therapeutic radiation exposure (RR=2.2, 95% CI 1.4-3.3, P<0.001) were associated with higher risk for SMN …
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Targeted Inhibition of Pi3K, Mtor, and Igf1R For The Treatment of Undifferentiated Pleomorphic Sarcoma
<p>Undifferentiated pleomorphic sarcoma (UPS) is an aggressive mesenchymal malignancy largely devoid of indicators for its originating tissue. Surgery remains the standard of care, as radiation therapy and systemic chemotherapy have limited efficacy in UPS patients with localized and metastatic …
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Poly (Adp) Ribose Polymerase Inhibitors For The Treatment of Malignant Peripheral Nerve Sheath Tumor
… nerve sheath tumor (MPNST) is a rare subtype of soft tissue sarcoma. Surgical excision has remained the standard of care for this highly aggressive malignancy for over a decade. Conventional chemotherapy and radiotherapy have shown limited efficacy in MPNST; therefore, it is imperative that …
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MODEL OF ESTIMATION OF LOCAL CONTROL AND SURVIVAL BENEFIT OF EXTERNAL BEAM RADIOTHERAPY FOR SELECTED CANCERS
… and ‘other’ (anus, non-melanoma skin cancer, soft tissue sarcoma) cancers were extended to incorporate benefit estimates of radiotherapy alone (RT alone) and of radiotherapy with concurrent chemotherapy (CRT). Literature review (1990-2015) was conducted to identify benefit estimates of …
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A tumour suppressor role for the T-box transcription factor TBX3 in fibroblasts
… and little is known about the role ofTBX3 in sarcomas of mesenchymal origin. This study provides novel evidence to show that TBX3protein, but not mRNA, is upregulated in a number of transformed fibroblast and fibrosarcoma cell lines of mesenchymal origin. Fibro sarcoma is an aggressive …
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Incidence of cancer among residents of high temperature geothermal areas in Iceland: A census based study 1981 to 2010
… larynx, prostate, thyroid gland and for soft tissue sarcoma; however the 95% CI included unity. Conclusion: More precise information on exposure is needed to draw firm conclusions from the findings. The significant excess risk of breast, and basal cell carcinoma of the skin, and the …
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The role of T-box transcription factor TBX3 in rhabdomyosarcoma
… TB X3 is also overexpressed in a wide range of sarcoma subtypes including rhabdomyosarcomas. This suggests that TBX3 may also contribute to the development and/or progression of sarcomas and potentially may serve as a biomarker for their diagnosis and targete d therapy. This is exciting because …
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Identification of new therapeutic targets for undifferentiated pleomorphic sarcoma
Undifferentiated pleomorphic sarcoma (UPS) is a rare and highly aggressive soft tissue sarcoma with vast unmet treatment needs, both in curative options and the prolongation of survival. The heterogeneity and limited understanding of the targetable alterations within UPS have proven to be …
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