Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"soft substrates"”.
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Kinetics of cell attachment and spreading on hard and soft substrates
A very important aspect for the functioning of an organism is that cells adapt their behaviour to external stimuli. They continuously interact with their environment, and biochemical and physical cues can activate cellular signalling, which leads to changes in cell behaviour such as proliferation …
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Finite element modeling of contact stresses during the indentation of wear resistant coatings on soft substrates
Includes bibliographical references (pages 152-161).
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Applications of Traction Force Microscopy in Measuring Adhesion Molecule Dependent Cell Contractility
… hydrogels as controlled elastic modulus substrates for single cell traction force microscopy studies. The first section describes the use of EDC/NHS chemistry to convalently link microbeads to the hydrogel matrix for the purpose of performing long-term traction force studies (7 days). The …
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Control of cell fate decisions of embryonic stem cells by mechanical forces
… evidences implicate mechanical properties of the substrates, upon which the cells adhere, to influence critical biological functions including cell fate decisions in mesenchymal stem cells. However, how embryonic stem cells respond to forces or underlying substrates is not clear at this time. The …
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SOFT ADAPTIVE NANOCOMPOSITES BASED ONMETALLIC CLUSTER ASSEMBLED NETWORKS FORUNCONVENTIONAL DATA PROCESSING
… continuous increase in distributed sensors and soft autonomous systems is pushing toward the development of electronic devices capable of performing local data processing while being directly integrable into soft and deformable platforms. In this framework, unconventional computing approaches …
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Effects of substrate stiffness on bacterial biofilm formation
… that the cells attached on relatively stiff substrates were significantly shorter than those on relatively soft substrates, and the distribution of cell length was narrower on stiff substrates. In addition to the difference in size, the cells on stiff substrates were also found to be less …
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Examining the emergent properties of neuronal networks towards the creation of oscillatory biological machines
Made available in DSpace on 2018-03-13T17:28:55Z (GMT). No. of bitstreams: 2 LIU-DISSERTATION-2017.pdf: 6306728 bytes, checksum: 9cff0e840219845c90be2adfe5688a53 (MD5) LICENSE.txt: 4207 bytes, checksum: b44f37e1a190e4e9c44fe34c91f0ed34 (MD5) Previous issue date: 2017-08-10
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Mechanical Property and Phenotype Characterization of an in vitro Model for Afterload-triggered Cardiac Hypertrophy
… HCM and other iPSC-based heart disease models, soft substrates like Polydimethylsiloxane (PDMS) or hydrogels have been used as stiffness matrix. However, these substrates that have constant mechanical properties have the disadvantage of being unable to mimic dynamic changes in cells’ environment …
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Phenotypic Characterization of Segmental Human Trabecular Meshwork Cells
… CTGF, and MMP1 mRNA in segmental cells seeded on soft and stiff hydrogels, and on glass (control) were assessed; (2b) and phagocytic ability with/without DEX for 72 h, was quantified. Results: (1) LF VehM was 2-fold stiffer than HF VehM (p < 0.05). Moduli of HF and LF GIM were greater than …
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Extrinsic regulation of fate choice in mouse haematopoietic stem cells
… showing that HSCs are better supported on soft substrates, implicating physical forces in influencing HSCs maintenance ex vivo. In conclusion, these findings further confirm that SCF is a key regulator of HSCs fate, but is not essential for the retention of HSCs function. The newly …
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Cell biomechanics of the central nervous system
… environment, cells were also grown and tested on substrates of various stiffness, with the softest substrate mimicking the stiffness of brain tissue. Results of this study showed both the morphology and measured force response of astrocytes to be significantly affected by the stiffness of their …
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Cadherin specificity in adhesion and mechanotransduction
… responses to both external applied forces and soft substrates via classic type I cadherins. Cells respond to applied force through cadherin bonds by reinforcing the bead-cell junction, showing cadherin complexes are force-sensors. Besides, depending on cell context, the cadherin …
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Development of a novel cell traction force transducer based on cholesteryl ester liquid crystals. Characterisation, quantification and evaluation of a cholesteryl ester liquid crystal based single cell force transducer system.
… cellular generated tension can be measured by soft substrates based on polymers but these techniques are limited either by spatial resolution or ability to detect localised cell traction forces (CTF) due to their non-linear viscous behaviour under shear rates. A newly developed cell traction …
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Cancer metastasis and elasticity of microenvironment
… the original E cells that were never exposed to soft substrates (Chapter 5). Furthermore, we demonstrated additional cancer cell lines (SW480, HCT116 colon cancer cells and DU145 prostatic cancer cells) also exhibit a similar E-R transition following culture on the appropriate mechanical …
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Mechanics driven architectures for flexible nanomaterial-based sensors
… as well as the integration of ultrathin or soft substrates. Notably, nanomaterials offer exciting tunable physical, chemical and electrical properties that significantly surpass their bulk counterparts. As a result, they have captivated academic and industrial interests for use as electrical …
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The mechanical regulation of Eph/ephrin signalling in the developing Xenopus brain
… at early stages, the Xenopus optic tectum was soft and mechanically homogenous. However, as RGC axons approached the optic tectum, a stiffness gradient developed across it, with low stiffness anteriorly to high stiffness posteriorly. This stiffness gradient correlated both spatially and …
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Engineering the micro-environment to control the fate of mammalian cells
… of the underlying substrate. Cells cultured on substrates with elasticity comparable to the native myocardium (18 kPa) exhibited the highest beating rate during the first few days of culture. Higher percentage of mature focal adhesions were seen on cells on stiffer substrates (50 kPa or …