Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"sodium-dependent"”.
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Effects of Chronic High Sucrose With Dietary or Drinking Inclusion on the Electrogenic Glucose Absorption in the Intestinal Tract of Mice (Mus musculus)
… type-2 diabetes, on the intestinal electrogenic sodium dependent glucose transport, the first portal of entry for glucose, is unknown. Here female C57bl/6 mice fed a normal standard chow diet, and 20% sucrose in the drinking water for 8 months, or 35% sucrose inclusion in the diet for 12 months …
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Studies of the expression and characterization of various transport systems at RBE4 cells, an in vitro model of the blood-brain barrier
… nmol/mg/min. Furthermore the expression of two sodium dependent transporters, the 5-HT transporter (SERT) and the organic cation/carnitine transporter OCTN2, was shown at the RBE4 cells. Uptake studies with radiolabeled 5-HT exhibited a saturable, sodium dependent transport at RBE4 cells with a …
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Subcloning and regulation of a human intestinal sodium-phosphate cotransporter gene
… transporter gene(s) involved in the intestinal sodium-dependent phosphate absorption in human and to investigate the role of sodium-phosphate (NaPi) transporters in phosphate homeostatic regulation. The research was performed to test the hypothesis that the sodium-dependent phosphate (NaPi) …
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Preparation and Use of Bovine Jejunal Brush Border Membrane Vesicles to Investigate Amino Acid Uptake (Nutrient, Ruminant, Absorption, Cattle, Transport)
… to vesicular membranes. Vesicles exhibited sodium dependent and independent substrate uptake pathways and were able to discriminate between substrate stereoisomers for uptake. Major differences were not detected between results obtained with vesicles prepared from fresh or frozen intestines. …
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Non-electrolyte transport in brush border membrane vesicles from bovine small intestine
… D-glucose into an osmotically active space, was sodium stimulated, and inhibited by phloridzin, D-galactose, and D-xylose. Transport of L-alanine was sodium stimulated and mediated by at least two systems. Apparent affinities for L-alanine transport were .039, and .943 mM. Maximum velocities were …
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Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
… First, two vitamin transport systems including sodium-dependent multivitamin transporter (SMVT) and sodium-dependent vitamin C transporter (SVCT), which are responsible for the uptake and transport of biotin and ascorbic acid (AA), were investigated using in vitro cell culture models. The …
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Molecular transport properties of sodium/dicarboxylate cotransporters
… three distinct transporters, including the Na+-dependent di- and tricarboxylate transporters, NaDC1 and NaCT, and a sodium-independent pathway, possibly an organic anion transporter. Most of the succinate transport is mediated by sodium-dependent pathways, predominantly NaDC1. In contrast, …
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Knockout of the glutamate transporter GLT-1 specifically from neurons drastically alters transcriptome profiles in CA3, CA1, and Striatum
… maintaining glutamate homeostasis is a family of sodium-dependent glutamate transporters. GLT-1, the major glutamate transporter, is responsible for >90% of brain glutamate uptake. While previously thought to exist solely on astrocytes, the Rosenberg lab has identified GLT-1 as the major, if not …
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Taurocholat-Transport in isolierten proximalen Tubuluszellen der Ratte : Einfluss einer extrahepatischen Cholestase
… are nearly completely reabsorbed by the apical sodium-dependent bile salt transporter (asbt). Hence, with normal conditions, urinary excretion of bile acids is negligible low. During extrahepatic cholestasis, when bile acid concentrations in the plasma are enhanced, there is, according to our …
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Testing the Gliocentric Hypothesis of Brain Pathology
… glutamate receptors and the involvement of sodium and cell swelling. Investigation into glial sensitivity was carried out via live imaging of brain slice and optic nerve preparations from transgenic mice which specifically expressed GFP in either astrocytes or oligodendrocytes. Ischaemia was …
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Lysine and methionine transport by bovine jejunal and ileal brush border membrane vesicles
… procedure. Alkaline phosphatase and sodium-potassium adenosine triphosphatase served as the marker enzymes for the brush border and basolateral membranes, respectively. The brush border fraction was enriched 5.1-fold over the cellular homogenate. Purification of 10.1-fold over …
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Differentielle Regulation organischer Anionentransporter der Oatp-Familie bei Ethinylöstradiol-induzierter Cholestase der Ratte
… and hormone substitution. Impaired sodium-dependent uptake of bile acids has been associated with diminished expression of the basolateral Natrium/bile acid cotransporter (Ntcp), whereas sodium-independent uptake is maintained despite a down-regulation of the organic anion …
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Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
… transporters peptide transporter (hPEPT1) and sodium dependent neutral and cationic transporter (B [super 0,+]), respectively. The overall objectives of this study are to evaluate cytotoxicity and uptake of prodrugs in rabbit corneal epithelial cells in vitro, and also to estimate corneal …
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Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
… and another end with ligand (biotin) targeting sodium dependent multivitamin transporter (SMVT). We have successfully synthesized three biotinylated (B) derivatives (B-C2-cCDF, B-C6-cCDF, and B-C12-cCDF) and two lipid ester derivatives (C6-cCDF and C12-cCDF) of cCDF. Structure and purity of all …
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Novel Mechanisms of Kinase Independent Pro-Survival Functions of EGFR in Cancer
… have demonstrated that EGFR possesses kinase-independent pro-survival functions. A better understanding of the molecular mechanisms involved in the kinase-independent pro-survival functions of EGFR bears a great potential for developing new strategies for cancer therapy. Therefore, this study …
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Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation
… mRNA and protein abundance of the brush border sodium-dependent glucose cotransporter, SGLT-1. However, the minimum effective dose that is necessary to enhance intestinal function is unknown. Therefore, GLP-2 was coinfused with TPN at three physiological doses: low, moderate and high. Results …
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Route of Nutrient Administration Alters Intestinal Immune Cell Composition in Neonatal Piglets
… barrier-function, disaccharidase activity, sodium-dependent glucose transport, and immune cellularity were evident after 2 days of TPN, and persisted at one week of TPN. T-lymphocyte numbers was significantly correlated with tissue conductance, further supporting an association between …
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Sodium and glucose transport across the in vitro perfused midgut of the blue crab, Callinectes sapidus Rathbun
… of the present study are: (1) to investigate sodium transport across the midgut as well as the hindgut of Callinectes sapidus and the functioning of these two regions of the gut in osmotic and ionic regulation of the animal, and (2) to elucidate the mechanism of glucose absorption across the …
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GABA as a Putative Neurotransmitter in the Optic Lobes of the Crab HEMIGRAPSUS NUDUS
… analysis of uptake describe a high-affinity, sodiumdependent, metabolically active process, findings similar to uptake mechanisms described for GABA in vertebrate central nervous system and retinal tissue. Release of label from preloaded eyes was effected in a dose-dependent manner using high …
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Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
… study the differential expression of FR-α, sodium dependent multivitamin transporter (SMVT) and amino acid transporter B (0, +) in retinoblastoma (Y-79) and retinal pigment epithelial (ARPE-19) cells. Higher expression of FR-α, SMVT and B (0, +) at mRNA level was observed in cancerous Y- 79 …
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