Global ETD Search
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Showing 1 to 10 of 10 for “"sodium reabsorption"”.
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Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo
… early postnatal lethality due to massive loss of sodium and water associated with impaired epithelial sodium channel (ENaC) activity in kidney and colon. The aim of the present study was the analysis of the role of renal principal cell MR, which is activated by aldosterone, in ENaC-mediated sodium …
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The Effects of Accessory Proteins on ENaC Function
… can lead to heart and kidney disease. Epithelial sodium channels, also known as ENaC, constitute the rate-limiting step of sodium reabsorption in the distal tubules of the nephron in the kidneys. It is here the final, yet critical, 3% to 5% of sodium reabsorption that dictates blood pressure …
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Understanding Potassium Homeostasis Using Human and Mouse Genetic Models
… have revealed that WNK kinases regulate renal sodium transporters and potassium channels. WNK1 enhances the endocytosis of renal outer medullary potassium (ROMK) channel through an intersectin-dependent mechanism, but the upstream regulator is still unknown. Here, I clarified that the …
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Hormone-induced expression of the epithelial sodium channel in human airway cells
… of these dangerous conditions is due to active sodium reabsorption through the epithelial sodium channel (ENaC), which is crucial for lung fluid clearance. Although clinical prognosis can be improved by using glucocorticoid hormones to augment the ENaC-dependent removal of liquid from the lungs, …
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The Acute And Chronic Effects Of Resveratrol On Renal Function And Blood Pressure
… it may have a direct effect on renal tubular sodium handling independent of perfusion pressure, renal blood flow, or changes in renal vascular resistance. We hypothesized chronic ingestion of resveratrol would reduce Ang II-induced and fructose-induced salt-sensitive increases in blood …
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Thick Ascending Limb Nitric Oxide Production And Inhibition Of Nkcc2 Activity Are Impaired In Angiotensin Ii-Induced Hypertension
… of this disease. Inappropriately elevated sodium reabsorption by the kidney contributes to hypertension; therefore, studying the mechanisms that lead to enhanced sodium transport is important in understanding this pathology. The thick ascending limb (THAL) reabsorbs 30% of the filtered …
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Identification of Residues Critical to Epithelial Sodium Channel Assembly
The Epithelial Sodium Channel (ENaC) is a major determinant in fine-tuning the volume and pressure of blood within the cardiovascular system. Understanding the regulation, structural assembly, and arrangement of ENaC is needed. This study describes a method for identifying residues that participate …
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AN INVESTIGATION OF THE MECHANISM BY WHICH ALUMINIUM AND OTHER POLYVALENT CATIONS INHIBIT ECCRINE SWEATING
… antiperspirant action by interfering with ductal sodium reabsorption in the lower sweat duct.
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Investigating the Influence of NEDD4L in the Development of Salt Sensitive Hypertension with Age
… The NEDD4-like (NEDD4L) protein is important in sodium reabsorption and has been implicated in essential hypertension and salt sensitivity. Objectives: Two variations (rs4149601/rs2288774) found in NEDD4L have been associated with salt sensitivity and hypertension; a third (rs576416) is in …
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Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension
… of proximal tubule transporters on the renal sodium handling in obese hypertensive (OP) and lean normotensive (OR) rats. An acute increase in renal perfusion pressure resulted in a blunted natriuretic response in OP vs. OR rats and indicated that increased sodium reabsorption in the proximal …