Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"sodium current"”.
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The cyclic AMP-activated sodium current in the molluscan neuron: A kinetic analysis of regulation by diffusion, phosphodiesterase and calcium ion
… kinetics: it varied in latency to current onset, latency to peak amplitude, and amplitude with the distance of the membrane to the tip of the iontophoretic cyclic AMP injection electrode; the phosphodiesterase inhibitor isobutylmethyxanthine (IBMX) in increasing concentrations …
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Human Nav1.5 F1486 deletion associated with long-QT syndrome leads to deficiency in inactivation and reduces lidocaine sensitivity
The cardiac voltage-gated sodium channel α subunit Nav1.5 generates the cardiac sodium current, which is essential for the initiation and propagation of the cardiac action potentials. Mutations of SCN5A, the gene that encodes Nav1.5, have been well documented to cause long-QT syndrome (LQTs) by …
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Development and Mechanism of Oxygen Sensitivity in Caudal Hypothalamic Neurons
… frequency that was due to a sustained inward current. Interestingly, this inward current response was no different in magnitude between neurons from immature and mature rats. Pharmacological analyses demonstrated that this inward current response was due to sodium and not calcium current. This …
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Mechanism of Atrial Fibrillation in Lamin A/C Cardiomyopathy
… SNP, rs6801957, which is known to regulate sodium current, leads to reduced sodium current in LMNA-S143P iPSC-aCMs. In conclusion, we demonstrate how a LMNA variant and common polymorphisms disrupt shared gene regulatory networks underlying arrhythmia susceptibility, highlighting the need to …
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Mechanisms of ventricular arrhythmogenesis in the age dependent Pgc-1β -/- model of mitochondrial dysfunction.
… earlier experiments and their effect on cellular currents in a physiological environment which show a physiological deficit in sodium current density. At all stages care was taken to perform experiments in the least disruptive manner, maintaining as much physiological relevance as possible. The …
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MES-DERIVED CARDIOMYOCYTES AS CELLULAR MODEL TO STUDY CARDIAC DISEASES: ALTERATIONS IN STRN AND GNB5 GENES
… This was likely due to an increased late Na+ current (INaL) and a reduction of Ca2+extrusion through the Na+/Ca2+ exchanger (NCX). Other currents such as ICaL, If and IKr were not altered in STRN-KO cells. Incubation of STRN-KO CMs with the microtubule stabilizer Taxol, induced a reduction of …
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Sensory Transduction in Enteroendocrine Cells
… hormone release. In KRJ-I cells two outward currents were observed. In STC-1 cells three types of ionic currents were identified; a large outward voltage gated potassium current, a tetrodotoxin-sensitive voltage gated sodium current and a nifedipine-sensitive persistent calcium …
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Mathematical modelling of pulsatility in neuroendocrine systems.
… cells and methods of recording selected ionic currents are the subject of chapter three. Chapter four presents a discussion of oscillatory behaviour in nerve cells at a general level and outlines the features necessary for a nerve cell to exhibit oscillation. The next three chapters discuss the …
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Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
The voltage-gated sodium channel Nav1.7 has gained traction as a pain target with recognition that loss-of-function mutations in SCN9A, the gene encoding Nav1.7, are associated with congenital insensitivity to pain, whereas gain-of-function mutations produce distinct pain syndromes due to increased …
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VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
Voltage gated sodium channels (VGSCs) are multimeric protein complexes formed by one alpha subunit, responsible of pore formation and of the regulation of the state of the channel, and by one or two accessory beta subunits that have an important role in the regulation of alpha subunit localization …
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Spontaneous activity in the mouse visual cortical slice: biophysical characterization and pathophysiology
… by altering the activity of the persistent sodium current. In Chapter 3, I detail my journey investigating the pathophysiology underlying the hyperactivity phenotype in Fmr1-KO mice. While my early investigations indicated that depolarized intratelencephalic layer 5 pyramidal neurons drive …
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Augmentations vs. Restoration: A computational study of the effects of bacterial sodium channels on cardiac conduction.
… Augmentation of cardiomyocytes with exogenous sodium channels such as Nav1.4 or prokaryotic voltage-gated sodium channels, or BacNavs, have shown promise for potentially alleviating these arrhythmias. However, due to size constraints, only the BacNavs are available for the highest efficiency …
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Exploring mechanisms of inhibition and inactivation in voltage-gated sodium channels using molecular simulations
Voltage-gated sodium (Nav) channels play a pivotal role in the conduction of electrical signals across the human body, with different subtypes expressed across excitable tissue in the brain, heart and muscle. Nav channels transiently form transmembrane pores by cycling through the closed, open and …
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Exploring mechanisms of inhibition and inactivation in voltage-gated sodium channels using molecular simulations
Voltage-gated sodium (Nav) channels play a pivotal role in the conduction of electrical signals across the human body, with different subtypes expressed across excitable tissue in the brain, heart and muscle. Nav channels transiently form transmembrane pores by cycling through the closed, open and …
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Modelling Brugada Syndrome using induced pluripotent stem cells
… The majority of mutations involve the cardiac sodium channel gene SCN5A and give rise to classical symptoms, which include an abnormal electrocardiogram with ST segment elevation and a predisposition to ventricular fibrillation. To date, the implantation of a cardioverter defibrillator is the …
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Functional Characterization of the Mammalian TRPV4 Channel: Yeast Screen Reveals Gain-of-Function Mutations
… channels that mediate flux of calcium and sodium into cells, leading to depolarization as well as activation of calcium-mediated second-messenger signaling pathways. The TRP channel family is large and diverse in terms of tissue expression, mechanism, and function; therefore, …
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Die Rolle der Kalzium-Calmodulin-abhängigen-Proteinkinase II δc (CaMKIIδc) bei der Radikal-vermittelten Zytotoxizität in isolierten ventrikulären Kaninchenmyozyten
Sauerstoffradikale sind an einer Reihe von pathologischen Vorgängen beteiligt, wie z.B. an Ischämie, der darauffolgenden Reperfusionsphase, an Alterungsprozessen sowie bei Herzinsu.zienz. Sie verursachen Zellschäden, haben allerdings auch wichtige Funktionen in Signaltransduktionswegen. …