Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"sodium channel"”.
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Regulatory mechanisms of epithelial sodium channel
Epithelial sodium channels (ENaC) are of immense importance, controlling Na+ transport across epithelia and thus playing a critical role in all aspects of fluid clearance as well as numerous other functions. Although extensive studies have been carried out to invistegate the regulation mechanism of …
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Identification of Residues Critical to Epithelial Sodium Channel Assembly
The Epithelial Sodium Channel (ENaC) is a major determinant in fine-tuning the volume and pressure of blood within the cardiovascular system. Understanding the regulation, structural assembly, and arrangement of ENaC is needed. This study describes a method for identifying residues that participate …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… activity involves activation of voltage-gated sodium channels (VGSCs) primarily, in this study, we used a sodium channel activator, brevetoxin-2 (PbTx-2) to mimic neuronal activity. Brevetoxins interact with binding site 5 on the α subunit of VGSCs. PbTx-2 was found to increase intracellular …
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Sodium channel regulatory mechanisms : current fluctuation analysis on frog skin epithelium
… mechanisms of the amiloride-sensitive Na⁺ channels in isolated frog skin epithelium. The epithelium from ventral frog skin is a model tissue which has proved significant in our understanding of the basic principles involved in water and Na⁺ homeostasis. In particular, this project examines …
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Identifying Protein Interactors of Voltage-Gated Sodium Channel Nav1.6 in Native Tissue
Voltage-gated sodium (Nav) channels play a critical role in the initiation and propagation of action potentials in excitable cells and are involved in numerous neurological diseases such as epilepsy, neuropathic pain, and cancer. Although approved drugs targeting Nav channels are available, they …
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Hormone-induced expression of the epithelial sodium channel in human airway cells
… of these dangerous conditions is due to active sodium reabsorption through the epithelial sodium channel (ENaC), which is crucial for lung fluid clearance. Although clinical prognosis can be improved by using glucocorticoid hormones to augment the ENaC-dependent removal of liquid from the lungs, …
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VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
Voltage gated sodium channels (VGSCs) are multimeric protein complexes formed by one alpha subunit, responsible of pore formation and of the regulation of the state of the channel, and by one or two accessory beta subunits that have an important role in the regulation of alpha subunit localization …
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Renal Epithelial Sodium Channel (ENaC) Regulation of Pregnancy Mediated Hemodynamic Adaptations: Mechanistic Insights
<p>Pregnancy-mediated sodium (Na) retention is required to provide an increase in plasma volume for the growing fetus. The mechanisms responsible for this Na retention are not clear. In the first study, we generated a renal tubule protein profile indicating α ENaC as the only sodium transport …
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Sodium Channel Loss of Function Sensitizes Conduction to Changes in Extracellular Sodium Concentration
… of this dissertation, we address how changes in sodium concentration can alter conduction, despite conventional wisdom suggesting that it should not. We show that when sodium channels are impaired, such as by genetic mutation or pharmacologic blockade, that conduction is sensitized to changes in …
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Regulation of sodium channel densities in A6 renal epithelial cells by hormonally-dependent mechanisms
Epithelial sodium channels (ENaC) located in the apical membranes of transporting epithelia, such as cells of the renal distal nephron, constitute the rate limiting step in the transcellular transport of sodium. The regulation of sodium ion reabsorption in the kidney, which is essential for salt …
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The Voltage Gated Sodium Channel β1/β1B subunits: Emerging Therapeutic Targets in the Heart
Voltage-gated sodium channels are composed of pore-forming α-subunits, and modulatory and multifunctional associated β subunits. While much of the field of cardiac electrophysiology and pathology has focused on treating and preventing cardiac arrhythmias by targeting the α subunit, there is also …
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Uncovering the Critical Amino Acids in the Beta Bubunit of the Epithelial Sodium Channel (ENaC)
A high intake of sodium into the body can lead to high blood pressure that could result to stroke, kidney and heart disease. Sodium balance in the body is partially regulated in the distal tubules of the nephron in the kidney via a membrane channel called the epithelial sodium channel (ENaC). The …
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Regulation of signaling and function of the voltage-gated sodium channel complex by protein:protein interactions
… of neuronal function, voltage-gated Na+ (Nav) channels are important targets for therapeutic development against a wide range of health conditions. Dysfunction of Nav channels in the CNS is associated with disorders ranging from neurological (i.e., epilepsy, neurodegeneration) to psychiatric …
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Calcium-dependent changes of apical membrane sodium channel density and open probability in frog skin
Blocker-induced noise analysis of Na$\sp{+}$ channels at apical membranes of intact and isolated epithelia of frog skin was carried out to investigate whether treatment of tissues with ionomycin, quinine, or acidification of basolateral solution shared similar mechanisms of inhibition of Na$\sp{+}$ …
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The R563Q mutation of the beta subunit of the epithelial sodium channel : prevalence and effect
… to blood pressure is ongoing. The epithelial sodium channel genes were implicated when the beta subunit (SCNN1B, gene ID 6338) was found to have a mutation that caused Liddle’s syndrome. The R563Q mutation in the beta subunit has been associated with hypertension and pre-eclampsia in the Xhosa …
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The R563Q Mutation of the Beta Subunit of the Epithelial Sodium Channel: Prevalence and Effect
… to blood pressure is ongoing. The epithelial sodium channel genes were implicated when the beta subunit (SCNN1B, gene ID 6338) was found to have a mutation that caused Liddle's syndrome. The R563Q mutation in the beta subunit has been associated with hypertension and pre-eclampsia in the Xhosa …
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Sodium channel diversity in the vestibular ganglion : evidence for Nav̳1.5-like and Nav̳1.8-like currents
Voltage-gated sodium (Nav) channels are diverse, comprising nine known mammalian subunits, which are classified pharmacologically into tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-insensitive (TTX-1) categories. The pattern of Nav channel expression shapes response properties of neurons, while …
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