Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"soce"”.
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Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells
The store-operated calcium entry (SOCE) pathway is an important route for generating cytosolic Ca2+ signals that regulate a diverse array of biological processes. Abnormal SOCE seem to underlie several diseases that notably include allergy, inflammation, acute pancreatitis and cancer. Therefore, …
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Structure-based development of novel chemical scaffolds as inhibitors of the store-operated calcium entry pathway
… activities. The ‘store-operated calcium entry’ (SOCE) is a significant, almost ubiquitous Ca2+ signaling pathway and is triggered when intracellular Ca2+ stores (e.g., endoplasmic reticulum, ER) are depleted, either physiologically or pharmacologically. SOCE is mediated by Orai proteins, mainly …
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Suppression of Ca2+ Signaling Enhances Melanoma Progression
… Hence, the role of store-operated Ca2+ entry (SOCE) in melanoma metastasis is still not fully elucidated. To address this, we examined UV-dependent metastasis, revealing a critical role for SOCE suppression. As previous literature demonstrated a role for cholesterol (CHL) in melanoma …
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Stoichiometry of the interactions between endogenous Orai1 and STIM1 during store-operated Ca2+ entry
… growth to apoptosis. Store-operated Ca2+ entry (SOCE) is a major pathway of Ca2+ signalling and exists in almost all metazoans. SOCE is activated by loss Ca2+ from the endoplasmic reticulum (ER), which causes stromal interaction molecule 1 (STIM1) to accumulate at junctions between the ER and …
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HUMAN CLCA2 MODULATES THE CONDUCTANCE OF CALCIUM-ACTIVATED CHLORIDE CHANNELS BY REGULATION OF INTRACELLULAR CALCIUM
… and by subsequent store-operated calcium entry (SOCE). Therefore, we investigated whether CLCA2 could increase intracellular calcium levels. With Fluo-4 dye calcium imaging, we found that CLCA2 expression enhanced both ER calcium stores and SOCE upon exhaustion of intracellular stores, and the …
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Pharmacological regulation and function of store-operated calcium channels
Store-operated Ca²⁺ entry (SOCE) is an important Ca²⁺ influx pathway existing in almost all types of mammalian cell. STIM1, ORAI and TRPC have been regarded as the molecular basis of SOCE. Once the endoplasmic reticulum (ER) Ca²⁺ store is depleted, STIM1 proteins move to the plasma membrane and …
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Remodelado de la entrada de calcio en la angiogénesis: papel de las proteínas ORAI1 Y SARAF
… sugieren que el cambio de [Ca2+]i regulado por SOCE, del inglés store-operated calcium entry, tiene un papel fundamental en el proceso de angiogénesis. Sin embargo, siguen siendo escasos los conocimientos sobre el papel que desempeñan en este proceso sus proteínas claves, entre ellas, SARAF, el …
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S-Acylation Is A Key Regulator of Orai1/Stim1-Mediated Store-Operated Calcium Entry In T Cells
… for store-operated Ca<sup>2+</sup> entry (SOCE) in T cells and subsequent signaling events leading to T cell activation, proliferation, and differentiation. Plasma membrane (PM)-localized Orai1 is the pore-forming subunit of the CRAC channel, and STIM1 is the Ca<sup>2+</sup> sensor …
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Studies of calcium signalling mechanisms in human platelets
… and is known as store operated Ca2+ entry (SOCE). STIM1 is the Ca2+ sensing protein of the endoplasmic reticulum (ER) which activates Orai channels in the plasma membrane allowing Ca + entry. However, not all of the details of Ca2+ entry are understood. In platelets, two other pathways also …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… target. Store operated calcium entry (SOCE) allows refilling of depleted ER-Ca2+ stores in non-excited cells, including in synthetic VSMCs, and supports migration and proliferation of synthetic VSMCs. Herein, we identify a critical role for PDE1C in regulating the polarization of …
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Angiotensin II signalling in sensory neurons
… followed by store-operated Ca2+ entry (SOCE). SOCE downstream of Ang II application was found to be mediated by the non-selective cation channel, TRPC3, activated by the endoplasmic reticulum Ca2+ sensor, STIM. Incubation of sensory neurons with Ang II induced to nuclear translocation of …
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MicroRNA-184: A Multifaceted Regulator of Epidermal Keratinocyte Biology
… pathway called store-operated calcium entry (SOCE). Furthermore, miR-184 was upregulated in a cohort of eight psoriasis patient samples. By modulating miR-184 expression it was elucidated that miR-184 promotes early keratinocyte differentiation through concomitant induction of factors related …
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The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels
… Ca2+ATPases, and store-operated Ca2+ entry (SOCE). However, how these pathways interact to create precise signals is not well understood. In a pancreatic model of dysregulated Ca2+ homeostasis, secretory pathway Ca2+ATPase 2 (SPCA2) expression is significantly decreased. In the pancreas, only …
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The Role of Calcium Signalling in Autophagy
… known as ‘store-operated Ca<sup>2+</sup> entry’ (SOCE), was activated by depleting endoplasmic reticulum Ca<sup>2+</sup> stores using inhibitors of sarco/endoplasmic reticulum ATPases (SERCA). It was found that sustained cellular Ca<sup>2+</sup> signals arising via chronic inhibition of SERCA were …
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Remodelado de la entrada de calcio operada por los reservorios y su regulación por micrornas en la reestenosis vascular
… de los reservorios intracelulares, conocido como SOCE (Store Operated Ca2+ Entry), en un modelo animal de angioplastia carotídea y su papel en el remodelado vascular asociado a la formación de la neoíntima. Los resultados revelaron un incremento de la expresión de Orai1, STIM1 y Saraf en las …
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Ca2+ signalling between the endoplasmic reticulum and lysosomes
… and activation of store-operated Ca2+ entry (SOCE). Lysosomes are the core digestive compartments of the cell, but their importance as signalling organelles is also now widely appreciated. Accumulating evidence indicates that lysosomal Ca2+ is important for their physiological functions. …
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Modulation of cyclic adenosine monophosphate (cAMP) signalling and its therapeutic potential: pharmacological characterisation of PDE inhibitors
… of possible crosstalk between calcium through SOCE (store-operated calcium entry) and cAMP pathways, which both were found to contribute to cell growth modulation. The effect of the elevation of intracellular cAMP on cell proliferation was further explored through the direct activation of …
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Dual regulation of inositol 1,4,5-trisphosphate receptors by inositol 1,4,5-trisphosphate and phosphatidylinositol 4,5-bisphosphate
… where store-operated Ca<sup>2+</sup> entry (SOCE) takes place. Uncovering the mechanisms that govern IP<sub>3</sub>R regulation is an essential element in understanding the spatial and temporal patterns of Ca<sup>2+</sup> signalling. Phosphatidylinositol 4,5-bisphosphate …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… not involve store release via IP3 receptors and SOCE, suggesting that either PIP2 hydrolysis and/or DAG generation lead to channel activation. Both, disruption of F-actin polymerization and the tarantula toxin GsMTx4 abolished the rises, suggestive that mechanosensitive stimulation is involved. …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… not involve store release via IP3 receptors and SOCE, suggesting that either PIP2 hydrolysis and/or DAG generation lead to channel activation. Both, disruption of F-actin polymerization and the tarantula toxin GsMTx4 abolished the rises, suggestive that mechanosensitive stimulation is involved. …
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