Global ETD Search
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Showing 1 to 16 of 16 for “"snoRNA"”.
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snoDB: An interconnected online database of human snoRNA
… types to be discovered was small nucleolar RNAs (snoRNAs). Canonically pegged as guides for the modification of pre-ribosomal RNAs, these highly conserved RNAs now boast a diverse list of crucial non-canonical roles, notably in gene expression, as well as being associated to a myriad of diseases …
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Regulation of Metabolic Stress-Induced snoRNAs
… unsuspected role for small nucleolar RNAs: snoRNAs) as critical mediators of lipotoxic cell death.</p><p>Herein we show that under lipotoxic conditions, intronic snoRNAs in the <italic>rpL13a</italic> gene accumulate in the cytosol during metabolic stress, suggesting that these non-coding …
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Structural Studies of the Nucleolar Stages of Ribosome Biogenesis in Yeast
… for removing the U3 small nucleolar RNA (U3 snoRNA) from one of the earliest stable precursors of small subunit assembly called the SSU processome. Structures of the SSU processome revealed that the U3 snoRNA is a key architectural feature of this assembly intermediate. Basepairing between …
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A MECHANISM FOR CORTICAL BONE STEM CELL-DERIVED EXOSOMES’ THERAPEUTIC EFFECT ON POST-MYOCARDIAL INFARCTION REPERFUSION INJURY AND CARDIAC REMODELING
… in micro RNA (miRNA) and small nucleolar RNA (snoRNA), known to be involved with ribosome stability. A 24hr I/R study on 13wk old C57B/L6NJ mice showed that injection of mCBSCs and mCBSC-derived exosomes into the ischemic region of an infarct had a protective effect against I/R injury. …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… of obesity-associated immune suppression, snoRNA expression was profiled in human serum across a range of BMI values, revealing that SNORD46—a C/D box small nucleolar RNA—is elevated in obese donors and inversely associates with NK cell tumor infiltration across cancer types. Saturated …
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Präparation und röntgenkristallographische Untersuchungen an archaebakteriellen Box C/D sRNPs und einer neuartigen Glukosyltransferase aus Thermotoga maritima MSB8
… durch kleine nukleoläre RNAs (snoRNAs) modifiziert. Dabei kommt es zum einen zur Umwandlung von Uridin in Pseudouridin durch die H/ACA-Box snoRNAs und zum anderen zur 2'-O-Methylierung von Ribose durch Box C/D snoRNAs, wobei beide snoRNA-Familien mit spezifischen Proteinen zu …
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The Domains of The Catalytic Subunit of The Eukaryotic Rna Degrading Exosome, Rrp44P, Have Distinct Functions
… mature RNA species, including rRNA, snRNA, and snoRNA. In addition to processing these RNAs, the nuclear exosome is also involved in degrading aberrantly processed forms of these RNAs, and others, including mRNA. The 3’ to 5’ exoribonuclease activity of the exosome is contributed by the RNB …
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The Application and Challenges of RNA-Sequencing to the Study of Circadian Rhythms
… validation, and include important miRNA and snoRNA precursors. Additionaly, I found hundreds novel ncRNAs with rhythmic expression, which may provide novel CCGs. Lastly, I developped and applied a method for identifying the sources of bias in RNA-seq protocols. Taken together, this work …
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Sequence Dependence of the Folding of Kink-Turns in RNA
… kinked conformation in metal ions. The AfboxC/D snoRNA kink-turn, on the other hand, is unable to fold in metal ions and requires the binding of the L7Ae protein to fold. The reason for this variation lies in the kink-turn RNA sequence. Certain positions, namely G1b:A1n and A2b:G2n, are critical …
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Identifying Subunit Organization and Function of The Nuclear Rna Exosome Machinery
… the two enzymatic subunits is required for snoRNA biogenesis and possibly other cellular functions. These and future studies will help define the role of the TRAMP complex in the RNA degradation process and determine its importance for cellular viability. </p>
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Computational Analysis of High-Replicate RNA-seq Data in <em>Saccharomyces cerevisiae</em>: Searching for New Genomic Features
… the primary sequence produced a molecule (e.g. snoRNA or peptide) were designated as Primary. Annotations of regions where other types of activity were present (e.g. histone binding sites, double-strand break hotspots) were classified as Secondary. Only the Primary Annotations were used as …
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INTEGRATED TRANSCRIPTOMIC AND TRANSLATIONAL PROFILING OF EIF6-SBDS IN SHWACHMAN-DIAMOND SYNDROM REVEALS DIFFERENT CELLULAR STATES SHAPED BY RIBOSOME COMPOSITION AND FIDELITY
… pathways. Additional analyses of rRNA fragments, snoRNA dynamics, and inferred ribosomal-protein association provided complementary insight into consequences on ribosome assembly. Translation assays showed that both SBDS depletion and the N106S mutation reduce global protein synthesis. …
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A Census of Human RNA-Binding Proteins and Characterization of the DEDDh RNA Exonuclease NEF-sp in the 3' End Maturation of 28S Ribosomal RNA
… endonucleolytic cleavage reaction, guided by U8 snoRNA. Here I show instead that the 3'ETS is exonucleolytically trimmed by the DEDDh RNA exonuclease NEF-sp in Drosophila melanogaster. I characterize for the first time in higher eukaryotes a nuclease that is involved in the removal of the 3' ETS. …
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RNA binding proteins and snoRNAs change the ribosome dynamics in translation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01