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Showing 1 to 20 of 70 for “"snRNA"”.

  1. On co-transcriptional splicing and U6 snRNA biogenesis

    Listerman, ImkeTechnische Universität Dresden

    … (snRNPs). They consist of one of the U-rich snRNAs U1, U2, U4, U5 or U6 together with several particle-specific proteins and core proteins. All mRNA processing events can occur co-transcriptionally, i.e. while the RNA is still attached to the gene via Pol II. The in vivo studies of …

    qucosa-diss

  2. Conformational features of the human U2-U6 snRNA complex

    Bachu, RavichandraThe Graduate School and University Center of The City University of New York2014

    … the process. A complex formed between U2 and U6 snRNAs is implicated in the chemistry of pre-mRNA splicing. The catalytic activity of the U2-U6 snRNA complex is dependent on the presence of Mg2+ ions, and the complex has been shown to have several specifically bound Mg2+ binding sites in vitro. …

    cuny-grad Repository record

  3. Functional Analysis of Drosophila Integrator Complex In Snrna 3' End Processing

    Chen, Jiandong2013

    <p>Uridine-rich small nuclear RNAs (U snRNAs) play essential roles in eukaryotic gene expression by facilitating the removal of introns from mRNA precursors and the processing of the replication-dependent histone pre-mRNAs. Formation of the 3’ end of these snRNAs is carried out by a poorly …

    uthsc Repository record

  4. Structure and expression of a U1 snRNA gene from Arabidopsis thaliana

    Sturtevant, Ann PizanisUniversity of Illinois at Urbana-Champaign2011

    U1 snRNA is one of a group of spliceosomal snRNAs that function in the removal of introns from pre-mRNA. U1 snRNA is encoded by a small multigene family in Arabidopsis, consisting of between five and eight U1 genes. U1a snRNA is unique in having an extra U residue at position +2, which occurs in …

    uiuc Repository record

  5. The Role and Fate of Branch Site-U2 snRNA Interaction During Pre-mRNA Splicing

    Smith, Duncan

    … of accessing splicing catalysis experimentally. snRNAs likely form some or all of the spliceosomal active site. We attempted to establish an snRNA-only splicing system as a means to bypass assembly and recapitulate splicing catalysis. Our approach, however, yielded a 2'-3' bondforming ribozyme …

    rockefeller Repository record

  6. Conformation of the U12-U6atac snRNA Complex of the Minor Spliceosome and Binding by NTC-related Protein RBM22

    Ciavarella, JoannaThe Graduate School and University Center of The City University of New York2022

    … (U1, U2, U4, U5 and U6) and >100 proteins. snRNA components catalyze the two transesterification reactions while proteins perform critical roles in assembly and rearrangement. U2 and U6 snRNAs are the only snRNAs directly implicated in catalyzing the splicing of pre-mRNA. However, assembly …

    cuny-grad Repository record

  7. Investigation of the higher order structure of the spliceosomal RNA network

    Dönmez, Gizem2012

    … durch eine Fe-BABE tragende U2 snRNA untersucht. U2 snRNA nimmt eine Schlüsselstellung im nukleären prä-mRNA Spleißen ein. U2 snRNA trägt eine 5'-m3G Kappenstruktur und zahlreiche interne Nukleotidmodifizierungen. Zunächst untersuchten wir den Einfluß individueller modifizierter …

    goettingen Repository record

  8. Structure-Function Analysis of Human Integrator Subunit-4

    Sataluri, Anupama2013

    … Ph.D.</p> <p>Uridine-rich small nuclear RNAs (U snRNA) are RNA Polymerase-II (RNAPII) transcripts that are ubiquitously expressed and are known to be essential for gene expression. snRNAs play a key role in mRNA splicing and in histone mRNA expression. Inaccurate snRNA biosynthesis can lead to …

    uthsc Repository record

  9. Molecular analysis of peasnRNA variants

    Hanley, Brian AndrewUniversity of Illinois at Urbana-Champaign2011

    Five small nuclear RNAs (snRNAs) (U1, U2, U4, U5, U6) found in the nucleus of eukaryotic cells mediate the excision of introns from pre-mRNAs. The structure and expression of the snRNA components have been well documented in animal and yeast systems but little information has existed on the …

    uiuc Repository record

  10. Scaling up Genetic Circuits in Mammalian Cells: A U1-snRNA-based Platform Enables Mammalian Cells to Compute the Bitwise Inversion of the Square Root of a Number

    Alighieri, GiulioMassachusetts Institute of Technology2022

    … NOT gate based on a platform that uses the U1 snRNA. We have called this platform "u.P.R.O.C.E.S.S.O.R." (U-gene-based Platform, RNAi-regulated Only, Compactly Employing Small Shuttle-miRNAs, Operates (through) RNA), which does not use any transcriptional regulators or exogenous proteins, which …

    mit Repository record

  11. Sequences and factors required for 5' splice site selection in Schizosaccharomyces pombe

    Alvarez, Consuelo JackelineUniversity of Illinois at Urbana-Champaign2011

    … undertook a systematic study of the region of U1 snRNA complementary to the 5$\sp\prime$ splice site in S. pombe with the goal of expanding our knowledge of how this sequence functions in pre-catalytic events in pre-mRNA splicing. To determine the contribution to U1 function of each position …

    uiuc Repository record

  12. STRUCTURAL INSIGHTS INTO RNA POLYMERASE III PRE-INITIATION COMPLEX AND THE PIONEER ROLE OF OCT1

    SHAH, SYED ZAWARUniversità degli Studi di Milano2025

    … III (Pol III) is selectively recruited to snRNA promoters remain poorly understood. This is particularly notable because Pol II- and Pol III-transcribed snRNA promoters share highly similar architectures and rely on the same core transcription factor, SNAPc. How a single complex enables …

    milano Repository record

  13. Selective Neuronal Vulnerability in Neocortices from Patients with C9ORF72-related Neurodegeneration

    Kwa, Jing EugeneUniversity of Cambridge2023

    … was processed for single nuclei RNA-sequencing (snRNA-seq) and 10X Visium spatial transcriptomics (Chapter 2). I first investigated cortical neuron vulnerability using snRNA-seq (Chapter 3). Upper motor neurons (herein called L5 ETs: layer 5 extratelencephalic-projecting excitatory neurons) were …

    cambridge Repository record

  14. Exploring the gene regulatory dynamics of the maturing human brain

    Fillmore, StephanieDepartment of Human Biology2022

    … isolation protocol. Single nuclei RNA-seq (snRNA-seq) libraries were generated using the 10x Genomics Platform. snRNA-seq datasets were then sequenced and analysed using bioinformatics tools, including Cell Ranger and Seurat. The major cell types in the pediatric brain were identified, …

    cape-town Repository record

  15. A Cell Biological Determination of Integrator Subunit Localization

    May, Sarah B.2011

    <p>Uridine-rich small nuclear (U snRNAs), with the exception of the U6 snRNA, are RNA polymerase II (RNAPII) transcripts. The mechanism of 3’ cleavage of snRNAs has been unknown until recently. This area was greatly advanced when 12 of the Integrator complex subunits (IntS) were purified in 2005 …

    uthsc Repository record

  16. Structural studies of spliceosome assembly and catalysis

    Wilkinson, Max EdwardUniversity of Cambridge2019

    … catalytically active spliceosome, in which the snRNA components of the snRNPs mediate intron recognition and catalysis of splicing. Despite the importance of splicing to fundamental eukaryotic molecular biology, and the contribution alternative splicing makes to organismal diversity and disease …

    cambridge Repository record

  17. Regulation of INTS-6 by post-translational modifications: exploring phosphorylation, SUMOylation and their biological relevance in Caenorhabditis elegans

    Romero Aranda, CristinaUniversidad de La Rioja (España)2026

    … was initially thought to play a central role in snRNA processing, additional functions have been described since then in other key processes such as development, DNA damage response, and gene expression regulation. In this context and in line with the group's research efforts, the overall …

    dialnet Repository record

  18. Falta de procesamiento de snRNAs como biomarcador diagnóstico y pronóstico en el cáncer colorrectal

    Escrich Iturbe, VíctorUniversidad de La Rioja (España)2025

    … en el procesamiento de pequeños RNA nucleares (snRNA) que posteriormente participan en el proceso de escisión de intrones y unión de exones que da lugar al RNA maduro (splicing). Además, controla la pausa y liberación de la RNA polimerasa II (RNA pol II) en promotores de genes específicos en …

    dialnet Repository record

  19. Towards a complete human cell atlas: a single-nucleus RNA sequencing study of the paediatric and adult human brain

    Steyn, ChristinaDepartment of Human Biology2023

    … comprising of 6 single nucleus RNA sequencing (snRNA-seq) datasets generated from antemortem human brain tissue samples obtained during elective surgeries to treat epilepsy. To complement these, we included 6 snRNA-seq datasets from adult brain tissue. The 12 samples are all of temporal cortex …

    cape-town Repository record

  20. Electron microscopic localization of tagged proteins in the yeast S. cerevisiae spliceosomal U4/U6.U5 trisnRNP

    Häcker, Irina2012

    … der Aktivierung ist die Entwindung der U4/U6 snRNAs. Nur so kann dann die U6 snRNA mit der 5 Spleißstelle der prä-mRNA und mit der U2 snRNA interagieren, wodurch ein Teil des katalytischen Zentrums des Spleißosoms gebildet wird. Es konnte gezeigt werden, dass die U5-spezifischen Proteine …

    goettingen Repository record

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