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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"smooth muscle contraction"”.
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Modeling vascular smooth muscle contraction
… to investigate issues regarding vascular smooth muscle contraction. The overall structure of this thesis consists of (1) a model of single vascular smooth muscle cell membrane electrophysiology, contractile system kinetics and cell mechanics; (2) a model of signal transduction of …
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Regulation of smooth muscle contraction by protein phosphorylation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Comparison of Receptor Efficacies on Vascular Smooth Muscle Contraction
<p>Vascular smooth muscle contraction involves multiple signal-transduction pathways, the interrelations of which are not completely understood. Our objectives in this project were to compare the effects of phenylephrine (alpha<sub>1</sub>-adrenergic agonist, angiotensin II (AT<sub>1 …
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Developmental regulation of smooth muscle contraction in the urinary bladder
Smooth muscle cells in the urinary bladder are involved in the control of urine filling and emptying. We have used mice to study the contractile regulation of urinary bladder smooth muscle during the fetal period. We found that nerve-induced contractions are mainly dependent on muscarinic receptor …
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Mechanism of Action of Pentobarbital Induced Attenuation of Vascular Smooth Muscle Contraction
… (10 Hz, 0.3 ms, 50 V, 30 sec), and direct smooth muscle (MEFS) stimulation in the presence of TTX (10 Hz, 3 ms, 50 V, 30 sec). Rings, preloaded at 1 g, were immersed in an organ bath filled with Krebs solution at 37°C, and aerated with 95% 02:5% CO<sub>2</sub>. PB (1 mM) attenuated only the …
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Interactions of Smooth Muscle Myosin Filaments with Actin and Myosin Light Chain Kinase: Insights into the Mechanics of Smooth Muscle Contraction
The functional form of smooth muscle myosin (SMM) within cells is the filament. Smooth muscle contraction is thick (myosin) filament-regulated by phosphorylation of the myosin regulatory light chain (RLC). Upon phosphorylation of Serine 19 of the RLC of SMM by myosin light chain kinase (MLCK), SMM …
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Molecular Mechanism of Zipper Interacting Protein Kinase
<p>Diseases caused by smooth muscle dysfunction such as hypertension and asthma are major public health concerns, a better understanding of the signaling pathways that regulate smooth muscle contraction could identify new drug targets. The opposing effects of two enzymes; calcium/calmodulin …
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Local Control of Blood Flow in the Bronchial Circulation of Dogs
… mediates bronchial vasodilation during airway smooth muscle contraction. DMPX blocked vasodilation to infused adenosine (0.01-0.1/vmol/min). DMPX did not reduce the vasodilation during airway smooth muscle contraction evoked by stimulating airway afferents with hypertonic saline (ACbr = 4.7±1.2 …
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Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle
… wall angiotensin signaling, resulting in smooth muscle contraction which directly increases peripheral resistance. Calcium influx through voltage-gated L-type calcium channels underlies vascular smooth muscle contraction. Roughly half of calcium influx in these cells occurs through a small …
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Molecular and functional study of splice variations of the L-type voltage-gated calcium channel CaV1.2 alpha1-subunit
… excitability, gene expression, cardiac and smooth muscle contraction. Alternative splicing enriches the functional diversity of the pore-forming CaV1.2 alpha-1 subunit. Systematic screening of the human CaV1.2 alpha-1 gene by the transcript-scanning method revealed 19 of the 55 exons were …
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K+-Induced Smooth Muscle Calcium Sensitization Requires RhoA Kinase (ROK) Translocation to Caveolae Which Is Inhibited in Non-Neuronal Cell Memory
<p>KC1 causes smooth muscle contraction by elevating intracellular free calcium ([Ca<sup>2+</sup>]i<sub>)</sub>, while receptor stimulation activates an additional mechanism termed Ca<sup>2+</sup>- sensitization that can involve activation of ROK and PKC. However, recent studies support the …
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QUB-1073: a bioactive peptide from the skin secretion of Phyllomedusa rohdei
… activity on rat uterus and urinary bladder smooth muscle. <br/>A variety of biologically active peptides, including some new antimicrobial peptides and neuropeptides, have been extracted from the secretions of frog skins. Due to the abundant bioactive peptides and other compounds, the study …
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Factors influencing the responsiveness of human bronchi
The primary function of airway smooth muscle is to contract, regulating the airway tone and bronchial narrowing. Research extending over a number of decades has identified many of the major factors contributing to the degree of bronchial contraction at a cellular level including receptor mediated …
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The regulation of allergic airway disease by type V collagen-induced tolerance
… IgE, C3a, IL-17 expression and tracheal smooth muscle contraction. Crry/CD46 and CD55, key to preventing complement activation, were down regulated on goblet cells in murine allergic airway disease. Conclusions: Anti-col(V) immunity correlates with asthma pathogenesis, and col(V)-induced …
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Proteomic analysis of the olfactory mucosa, thoracic aorta, urinary bladder, and descending colon of smooth muscle alpha actin null mutant mice
Smooth muscle alpha actin is one of six mammalian isoforms and the predominant isoform in vascular smooth muscle. In mice and humans lacking functional SMAA, pathophysiological changes have been identified in the aorta, bladder, colon, and olfactory ensheathing cell population in the olfactory …
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Changes in the Expression of Thin Filament-Associated Proteins in Colonic Smooth Muscle from Mice During Inflammation
<p>The contractility of smooth muscle in inflammatory bowel disease and experimental colitis is reduced due to inhibition of neurotransmitter release and a decrease in the response of smooth muscle to contractile agonists. We and others have shown that inflammation induced by TNBS treatment alters …
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Regulatory and Gating Mechanisms of TMEM16A Chloride Channel
… and regulate transepithelial fluid transport, smooth muscle contraction, neuronal excitability and sensory signal transduction. Most other TMEM16 members are scramblases that mediate the flip-flop of phospholipids across the membrane to allow phosphatidylserine externalization, which is …
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Sex dimorphism in the cardiometabolic effects of the smoothelin-like 1 protein deletion in an ageing mouse model
The smoothelin-like 1 (SMTNL1) protein is a regulator of vascular homeostasis, wherein it modulates smooth muscle contraction, myogenic response, endothelial barrier function, and inflammatory responses. Vascular function is known to reciprocally influence cardiac function, with impaired diastole …
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Role Of Thromboxane Receptor-Alpha In Prostate Cancer Progression
… (TP) to induce platelet aggregation and smooth muscle contraction. TXA2 receptors are expressed as two different isoforms in humans, namely TP-alpha (TPα) and TP-beta (TPβ), which have common and distinct signaling pathways. Of the two TP receptor isoforms, studies have shown that TPα …
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Basal and agonist activated calcium sensitization pathways in murine gastrointestinal smooth muscles
… proteins in unstimulated gastrointestinal (GI) smooth muscles from regionally and functionally distinct regions and (2) addressing a fundamental question in the smooth muscle field; does exogenously applied agonist in the myobath and neural release of agonist induce similar Ca2+ sensitization …
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