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Showing 1 to 12 of 12 for “"smooth muscle cell proliferation"”.

  1. The role of mitochondria in regulating smooth muscle cell proliferation and migration in pulmonary hypertension

    Burzangi, AbdulHadi Salem H.University of Strathclyde2020

    Remodeling of the pulmonary arteries with proliferation and migration of pulmonary arterial smooth muscle cell (PASMC) is the hallmark of pulmonary hypertension, a proliferative disease with poor prognosis, which is exacerbated by hypoxic conditions. Hyperproliferation of PASMC underlies the …

    strathclyde Repository record

  2. The effect of mitogen-activated protein kinase phosphatase-2 (MKP-2) over-expression via infection with Adv.MKP-2 on human endothelial cell apoptosis and vascular smooth muscle cell proliferation

    Alharthi, Sameer E. M.University of Strathclyde2010

    strathclyde Repository record

  3. The role of heparan sulfate proteoglycans and heparanase in the control of vascular remodeling

    Baker, Aaron BlairMassachusetts Institute of Technology2006

    … mechanical strain on the ability of endothelial cells to inhibit vascular smooth muscle cell proliferation. Under these conditions we found mechanical strain increased endothelial inhibition of smooth muscle cell proliferation through increased production of heparan sulfate proteoglycans. Using …

    mit Repository record

  4. Heparanoid hydrogels for cardiovascular tissue regeneration

    Janse van Rensburg, AlizaDivision of Biomedical Engineering2015

    … to possess anticoagulative properties, inhibit smooth muscle cell proliferation, moderate inflammation and control angiogenesis by stabilization and potentiation of growth factors (GF). These properties are potentially very useful for the treatment of cardiovascular diseases, especially when …

    cape-town Repository record

  5. MAP kinase phosphatase-2 in vascular smooth cell muscle function

    Torrance, EmmaUniversity of Strathclyde2013

    … blood vessel; a process often driven by vascular smooth muscle cell hyperproliferation. A major mechanism by which smooth muscle cell proliferation occurs involves ligand-induced activation of MAP kinase signalling (Schad et al., 2011). MAP kinases have been noteworthy but troublesome targets in …

    strathclyde Repository record

  6. Pathology of uremic vascular diseases: calciphylaxis and arteriovenous fistula

    Le, John2021

    … and recovery. In this study, it is observed that smooth muscle cell proliferation, necrosis of muscle tissue, accumulation of proteoglycan in the intima, and scarring of collagen contribute to abnormalities observed in AVF.

    bu Repository record

  7. Age differentiation of rat smooth muscle cells : altered proliferation profile, cellular changes, and implications for atherosclerotic plaque destabilization

    Huang, Chen-Wen, 1979-Massachusetts Institute of Technology2004

    … plaque destabilization. The effect of aging on smooth muscle cells, a major cell type in the plaque, is central to the process of disease development yet is poorly understood. Therefore, we set out to study young and aged smooth muscle cells at the cellular level. Various aspects of …

    mit Repository record

  8. Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells

    Rakesh, KritiCreighton University2007

    … depends on the balance between release of extracellular matrix by human coronary artery smooth muscle cells (hCASMCs) and cytokines involved in inflammation. Insulin-like growth factor (IGF-i) is one of the most potent inducers of proliferation in hCASMCs, mainly through the activation of …

    creighton Repository record

  9. Eph-mediated restriction of cerebrovascular arteriogenesis

    Okyere, BenjaminVirginia Tech2019

    … of tissue. Arteriogenesis requires endothelial cell (EC) and smooth muscle cell proliferation, extracellular matrix degradation and recruitment of circulating bone marrow-derived cells (4-6). Unlike spouting angiogenesis, which requires weeks following occlusion to develop, arteriogenesis begins …

    vt Repository record

  10. CYP2D6 Inhibitory Activities of Sarpogrelate hydrochloride and Drug-Drug Interaction

    조, 두연2015

    … formation, vasoconstriction and vascular smooth muscle cell proliferation, all of which are mediated by 5-HT2A receptors, and consequently reduces the ischemic symptoms associated with peripheral artery disease. Despite the wide use and excellent pharmacological actions of sarpogrelate, to …

    ajou Repository record

  11. Smooth Muscle Hyperplasia Due to Acta2/Myh11 Mutations: Identification of Novel Pathology and Pathways Leading to Aneurysms and Diverse Vascular Occlusive Diseases

    Papke, Christina L2010

    Missense mutations in smooth muscle cell (SMC) specific ACTA2 (á-actin) and MYH11 (â-myosin heavy chain) cause diffuse and diverse vascular diseases, including thoracic aortic aneurysms and dissections (TAAD) and early onset coronary artery disease and stroke. The mechanism by which these mutations …

    uthsc Repository record

  12. Regulation of the nitric oxide receptor, soluble guanylyl cyclase

    Nedvetsky, Pavel I.Universität Würzburg

    … of this enzyme in regulation of vascular tone, smooth muscle cell proliferation, platelet aggregation, renal sodium secretion, synaptic plasticity, and other functions, extremely little is known about the regulation of sGC activity and protein levels. To date, the only well-proven …

    wurz-thes Repository record