Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"smooth muscle alpha actin"”.
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Proteomic analysis of the olfactory mucosa, thoracic aorta, urinary bladder, and descending colon of smooth muscle alpha actin null mutant mice
Smooth muscle alpha actin is one of six mammalian isoforms and the predominant isoform in vascular smooth muscle. In mice and humans lacking functional SMAA, pathophysiological changes have been identified in the aorta, bladder, colon, and olfactory ensheathing cell population in the olfactory …
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The Role of VEGF and Smooth Muscle Phenotype in Hypoxic Remodeling of Ovine Carotid and Cerebral Arteries
… in changes in status or behavior of the vascular smooth muscle within the vessel wall, likely secondary to changes in smooth muscle phenotype. This investigation examines the hypothesis that hypoxia induces vascular remodeling through transformation of vascular smooth muscle cell phenotype …
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Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
… identified genetic variants in the gene encoding smooth muscle alpha-actin, ACTA2, were modeled with Acta2-/- mice. I found that the ascending aorta and aortic root in these mice become significantly dilated over time. Acta2-/- mice are hypotensive, and increasing the blood pressure with a …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… Myosin Light Chain Kinase (MLCK) and Smooth Muscle Alpha Actin (SMαA) colocalization data shows that ET-1 promotes contractile dedifferentiation in normoxic but not hypoxic MCAs in a PKC, CaMKII, and p38 dependent manner. These results support the notion that chronic hypoxia has long …