Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 568 for “"smooth muscle"”.
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Lipotoxicity in smooth muscle
… However, lipotoxicity has not been shown in smooth muscle. The goal of this dissertation was to determine if lipotoxicity does occur in vascular smooth muscle and to determine how to modulate this lipotoxicity. We found that vascular smooth muscle takes up fatty acid and does not store it …
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Modeling vascular smooth muscle contraction
… to investigate issues regarding vascular smooth muscle contraction. The overall structure of this thesis consists of (1) a model of single vascular smooth muscle cell membrane electrophysiology, contractile system kinetics and cell mechanics; (2) a model of signal transduction of …
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The electrophysiology of smooth muscle
… investigations into the electrophysiology of smooth muscle were carried out by Bozler (1946) who studied the ureter, uterus and muscle of the intestine using external electrodes. He recorded action potentials similar to those which had been recorded from other excitable tissues during normal …
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Integration of signalling in smooth muscle caveolae
… in this thesis examine the role of caveolae in smooth muscle function. Ca2+-sensitization is a contractile process depending on inhibition of myosin phosphatase activity. Here I test whether protein kinase C and Rho-associated kinase-mediated Ca2+ sensitization depends on caveolae using gene …
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
… which shows increased activation in vascular smooth muscle cells (VSMCs) of advanced atherosclerotic plaques, specifically within the intimal layer. Since VSMC apoptosis plays a crucial role in the pathophysiology of atherosclerosis, we investigated the mechanisms underlying FOXO3a-mediated …
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Smooth muscle titin in embryo implantation and angiogenesis
Das Muskelprotein Titin ist mit einem Molekulargewicht von bis zu 3700 kDa das größte bekannte Polypeptid. Es ist nach Aktin und Myosin das dritthäufigste Protein im quergestreiften Muskel. Titin integriert in die Z-Scheibe und die M-Bande und überspannt damit das halbe Sarkomer. Es formt ein …
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Direct Reprogramming of Fibroblasts into Smooth Muscle Cells
… not form tumours in vivo and differentiated into smooth muscle cells (SMCs) when seeded on a Collagen IV substrate and maintained in differentiation media (DM). The PiPS-SMCs expressed a panel of SMC markers such as SMA, SM22 and Calponin at mRNA and protein levels. Immunofluorescent staining of …
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Regulation of smooth muscle contraction by protein phosphorylation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Activation of smooth muscle and theories of contraction
… four state model of regulation of contraction of smooth muscle. The model involves twenty one parameters: sixteen rate constants, three initial conditions, and NT$\sb3$ and NT$\sb4$, where N is the number of crossbridges, and T$\sb3$ and T$\sb4$ are the tension of phosphorylated and …
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Tensile Properties of Single Vaginal Smooth Muscle Cells
… level. In this study, we tested single vaginal smooth muscle cells (SMCs) to quantify their elastic moduli. Cells were enzymatically isolated from vaginal walls of freshly sacrificed, virgin Long Evans rats and cultured using well-established methods. A custom-built experimental setup was used …
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Interactions of Smooth Muscle Myosin Filaments with Actin and Myosin Light Chain Kinase: Insights into the Mechanics of Smooth Muscle Contraction
The functional form of smooth muscle myosin (SMM) within cells is the filament. Smooth muscle contraction is thick (myosin) filament-regulated by phosphorylation of the myosin regulatory light chain (RLC). Upon phosphorylation of Serine 19 of the RLC of SMM by myosin light chain kinase (MLCK), SMM …
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RHAMM Alters Vascular Smooth Muscle Cell Constrictive Matrix Remodeling
… in this dissertation was to determine whether smooth muscle cell (SMC) interactions with hyaluronan (HA) mediated by the receptor for hyaluronan-mediated motility (RHAMM), affects arterial SMC adhesion, migration and collagen matrix remodeling in vitro as well as constrictive remodeling …
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Epigenetic Modification of Phenotype in Intestinal Smooth Muscle Cells
Inflammation causes proliferation of intestinal smooth muscle cells (ISMC), contributing to the thickened intestinal wall and the dysmotility symptoms observed in inflammatory bowel disease (IBD). A unique consequence of Crohn’s disease (CD), a subset of IBD characterized by chronic, transmural …
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Signaling By Protease-Activated Receptors in Gastrointestinal Smooth Muscle
… their signaling pathways in rabbit gastric muscle cells. Immunoblot analysis revealed expression of PARl and PAR2 but not PAR3 or PAR4 in smooth muscle. The PARl agonist TFLLR activated Gq, G12, and Gi3, but not Gil, Gi2, G13, Gs or Gz, whereas the PAR2 agonist SLIGRL activated Gq, G13, Gil, …
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Smooth Muscle Cell Stress Response: Essential in Atherosclerotic Pathogenesis
… a previously undescribed and prominent role of smooth muscle cells (SMCs) in atherosclerotic plaque formation. SMCs undergo complex phenotypic modulation characterized by de-differentiation of SMCs and heterogeneously increased expression of markers for macrophages, fibroblasts, chondrocytes, …
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Comparison of Receptor Efficacies on Vascular Smooth Muscle Contraction
<p>Vascular smooth muscle contraction involves multiple signal-transduction pathways, the interrelations of which are not completely understood. Our objectives in this project were to compare the effects of phenylephrine (alpha<sub>1</sub>-adrenergic agonist, angiotensin II (AT<sub>1 …
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