Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"small-molecule antibiotics"”.
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Structural Studies on the Regulation of Sporulation in Bacillus and Antibiotic Sulfation
… transformations to the synthesis of small molecule antibiotics that can fend off competing species. Both of these topics will be the focus of this thesis, specifically the regulation of endospore formation in Bacillus and the generation of a sulfated small molecule antibiotic from an …
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New Tools for Diagnosis and Treatment of Bacterial Infections
The excessive and inappropriate use of antibiotics has contributed to the spread of antibiotic resistance, a serious challenge the global health industry is facing. To help preserve the effectiveness of current commercially available therapies, timely, accurate and user-friendly diagnostic tools …
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Targeting Airway Microbiome Dysbiosis for Preventing Pediatric Subglottic Stenosis
… the microbiome. Although conventional antibiotics and steroids are prescribed to reduce infection and inflammation, physicians advise against them as the risk of multi-drug resistance and growth retardation outweigh the potential benefits. Therefore, we use antimicrobial peptides …
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Efforts Toward Production of Novel Natural Products From Uncultured Soil Microbes
<p>The isolation of small molecule natural products from bacteria has led to the identification of many of the antibiotics currently in use today. Within the last 25 years, in fact, natural products (and their derivatives) account for almost three quarters of all antibiotic discoveries (Newman and …
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Small Molecules and Their Conjugates with Peptides: Chemical Strategies to Tackle Resistant Bacteria
… important issue as it renders currently used antibiotics ineffective. There are different approaches how to slow down emergence of resistance, including better stewardship of the current treatments, release of drugs in a more selective way, or discovery of new compounds and bacterial targets. …
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Discovery and Characterization of an Antibacterial Metabolite, Produced by a Death Valley Soil Microbe, Active Against Gram-Negative Bacteria
… genes. To address the urgent need for novel antibiotics, we considered exploiting natural products (NPs) produced by soil microorganisms. NPs are of major significance for antibacterial compounds, with 55% of approved antibacterials from 1981 to 2019 derived or inspired by NPs. NPs continue …