Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"small proteins"”.
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A Computational-Experimental Study of Small Globular Proteins
The folding of small globular proteins is studied using a combination of experimental and computational techniques. The use of several experimental probes to study the formation of secondary and tertiary structure of proteins is stressed to obtain a description of their folding. Molecular dynamics …
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A Computational - Experimental Study of Small Globular Proteins
The folding of small globular proteins is studied using a combination of experimental and computational techniques. The use of several experimental probes to study the formation of secondary and tertiary structure of proteins is stressed to obtain a description of their folding. Molecular dynamics …
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Regulation of E. coli SOS mutagenesis by dimeric intrinsically disordered umuD gene products
… Y family DNA polymerase V for mutagenic TLS. The small proteins UmuD2 and UmuD'2 make a large number of specific protein-protein contacts for their roles in regulation. This report chronicles experiments that indicate that umuD gene products share characteristics with intrinsically disordered …
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Motif discovery in sequential data
… novel antimicrobial peptides (AmPs). AmPs are small proteins used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than traditional antibiotics and may form the …
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Physiological roles and regulation of the cryptic prophage-encoded small protein DicB and small RNA DicF in Escherichia coli
… In the past decade, the important roles that small RNAs (sRNAs) and small proteins perform in regulating the stress response in bacteria has become evident. While the roles of numerous sRNAs and small proteins encoded on the bacterial core genome have been characterized, very few that are …
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Analysis of the composition of latent fingermarks by spectroscopic imaging techniques.
… detection of various antimicrobial peptides and small proteins in the fingermarks of a cohort of 80 donors using MALDI mass spectrometry profiling followed by multivariate statistical analysis in an attempt to differentiate donors based on their sex.Chemical imaging of latent fingermarks by SERS …
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Surface functionalisation of encoded SU-8 microparticles and their uses in multiplexed suspension biological assays
… of a range of biological molecules (e.g. proteins and peptides) onto the functionalised surfaces; and different on-bead analytical techniques for surface characterisation are described. From a thermodynamic study of a multiplexed immunoassay for immunoglobulins (Ig, MW ~150 kDa), the …
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Development of Novel Thermosensitive Polymers for Bioresponsive Drug Delivery
… by stimuli-responsive polymers is essential. A small or modest change in the environmental condition (e.g. temperature, pH, light) brings a sharp change in the properties of the responsive polymers. 'Smart' drug delivery systems utilize these principles to mimic the biological response behavior …
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Equine interferon-gamma and associated cytokines
Cytokines are small proteins or glycoproteins that mediate cellular growth and differentiation and regulate immune responses. Upon encounter with antigen, CD4+ T cells are able to influence the character of the immune response elicited through the expression of distinct types of cytokines. Thl …
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Hypervalent iodine reagents for protein functionalisation
… and chemoselectivity across a range of small proteins and polypeptides. In this work, we describe the development of a new generation of methionine-selective protein labelling reagents with improved reactivity and versatility, while enhancing the stability of the resultant protein …
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Nucleoid condensation in Escherichia coli by the DNAbinding protein SymE
… The toxins of all but two type I TA systems are small proteins that imbed into the inner membrane where they generally oligomerize and form pores that effect membrane permeability and proton gradient formation. symE/symR from Escherichia coli is characterized as a type I TA system with a …
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PEGylated Tissue Repair Peptide TP508 Derivatives as Second Generation Drugs for Radiomitigation and Other Systemic Applications
… method for modifying therapeutic peptides and small proteins to improve these characteristics is through covalent attachment to polyethylene glycol moieties, a process known as PEGylation. Because TP508 is currently being evaluated as a nuclear countermeasure drug for radiomitigation, this …
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Study of the HIV-1 Gene Regulatory Proteins TAT and REV by the Two-hybrid System in Yeast
<p>Tat and Rev, small proteins encoded by the Human Immunodeficiency Virus type 1 (HIV-1), regulate its pattern of gene expression within infected cells. Tat increases transcription from the integrated pro virus by approximately a thousand-fold; Rev effects a shift in the pattern of splicing of the …
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Sample preparation of membrane proteins suitable for solid-state MAS NMR and development of assignment strategies
… specific functions are carried out by membrane proteins (MPs) such as channels, ion-pumps and receptors. Additionally, it is known, that mutations in MPs are directly or indirectly involved in many diseases. Thus, structure determination of MPs is of major interest not only in structural biology …
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Photo Control of Protein Activity Using Genetically Encoded Photoswitches
… for light-switchable protein interactions. Small proteins that bind selectively to the light or dark states of PYP and Avena sativa light-oxygen-voltage domain (asLOV) were selected, characterized extensively in vitro. They were then used to control subcellular localization of a fluorescent …
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INVESTIGATING THE COMPETITION BETWEEN COMPONENTS OF DUAL-FUNCTION RNA
Non-coding RNAs (ncRNAs) and small proteins have both emerged as important regulators of gene expression. Dual-function RNAs encode a small protein and have a separate function as a regulatory RNA. Although first discovered in bacteria, dual-function RNAs have now been identified and characterized …
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Discovery and biochemical characterization of Casl3b, a Type VI-B CRISPR-Associated RNA-Guided RNase
… in disease. Particular CRISPR-associated (Cas) proteins are used for targeted DNA editing because they are easy to use, precise, and specific. CRISPR-Cas systems function in microbes as adaptive immune systems and are composed of endonuclease protein(s) with targeting guide RNAs that together …
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Fast flow biopolymer synthesis
… In the final chapter, a "D-scan" of two small proteins, the disulfide-rich Ecballium elaterium trypsin inhibitor II (EETI-II) and a minimized Z domain of protein A (Z33), is reported. For each protein, the chirality of one amino acid at a time was inverted to generate a series of …
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Intracellular delivery of rabbit monoclonal antibody
<p>In the past decades, a series of small peptides, Protein Transduction Domain (PTD), were discovered to be able to facilitate the delivery of small proteins into living cells. With the specific feature, researchers have successfully delivered some functional proteins into living cells. To fully …
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