Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"small protein"”.
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Approaches towards development of novel fluorogenic biosensors for detection of small protein analytes
… life is orchestrated by a relatively small repertoire of signaling molecules, which mediate communication between cells. Breakdown of these communication pathways can have profound consequences, leading to a multiplicity of developmental defects and disease states. In particular, the …
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Molecular analysis of small RNA and small protein regulation of Escherichia coli stress responses
Small RNA (sRNA) regulators control gene expression throughout all domains of life. In bacteria, they typically affect virulence, metabolism, and stress response genes posttranscriptionally through imperfect antisense pairing with their mRNAs. While most sRNAs are non-coding, a small number act as …
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Experimental verification of translational potential of computationally predicted small protein-coding regions in Arabidopsis thaliana
Thesis (M.S.)--Michigan State University. Plant Biology, 2010
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Physiological roles and regulation of the cryptic prophage-encoded small protein DicB and small RNA DicF in Escherichia coli
… In the past decade, the important roles that small RNAs (sRNAs) and small proteins perform in regulating the stress response in bacteria has become evident. While the roles of numerous sRNAs and small proteins encoded on the bacterial core genome have been characterized, very few that are …
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INVESTIGATING THE COMPETITION BETWEEN COMPONENTS OF DUAL-FUNCTION RNA
Non-coding RNAs (ncRNAs) and small proteins have both emerged as important regulators of gene expression. Dual-function RNAs encode a small protein and have a separate function as a regulatory RNA. Although first discovered in bacteria, dual-function RNAs have now been identified and characterized …
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Molecular Modeling: Elucidation of Structure/Function Relationships of Proteins and DNA at the Atomic Resolution
… packaging, internal migration of ligands in a small protein, and substrate specificity of an enzyme system.
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A study of the elongation of fibrils of the Alzheimer's amyloid beta protein with a coarse-grained force field
… is not yet well understood, research points to a small protein, the beta-amyloid peptide (Abeta), as the first suspect. Ab chains are present in the brains of healthy individuals, but in AD patients, they associate and form clumps that deposit outside neurons, and are believed to trigger the …
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The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation
… in the brain. It is well-established that protein synthesis is essential for both memory formation and the long-lasting changes in synaptic strength that accompany learning. However, it's still unclear when protein synthesis needs to occur relative to the experience to form durable …
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Characterizing small molecular weight proteins from Latrodectus hesperus dragline and tubuliform silks
<p>Spiders produce a diverse number of silk proteins that are well-known for their extraordinary mechanical and biological properties. Dragline silk has been the most prominent focus of research because of its exceptional high tensile strength and extensibility. In our research, we have focused on …
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Investigations of the inhibition mechanisms of human ribonucleotide reductase by gemcitabine-5'-diphosphate and saccharomyces cerevisiae ribonucleotide reductase by Sml1
… mechanism in S. cerevisiae. Smll is a 12 kDa small protein RNR inhibitor.
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Consequences of partial chromosome re-replication in mammalian cells
… heterohexameric complex of Cdt1 with a<br/>small protein called geminin. The consequences of either stabilising Cdt1 or<br/>ablating geminin in synchronised human U2OS cells are investigated in this<br/>PhD Thesis to elucidate the possible contribution of re-replication in …
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Engineering the interface of cytochrome b5 and myoglobin for in vitro and in vivo applications
Heme-copper oxidases (HCOs) are large membrane proteins found in both bacteria and in eukaryotes. They catalyze about 90% of oxygen reduction in the atmosphere. They utilize a heme-copper center, which is comprised of a heme and a copper ion coordinated with three histidines, to catalyze the …
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Protein structure determination using evolutionary information
… to optimize its sequence to perform a task. For protein-coding genes, the task includes folding, stability, and function. The record of the evolutionary process, which in itself is probabilistic, is contained within a multiple sequence alignment. A statistical model that accurately describes …
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Molecular Dissection of the Ubiquitin-Independent Degradation Signal At the Unstructured Amino Terminal End of Human Thymidylate Synthase
… regulates the turnover of many cellular proteins. Typically, proteins are targeted to and recognized by the proteasome through the covalent attachment of a small protein called ubiquitin. However, in recent years, several proteasomal substrates have been shown to be degraded efficiently …
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Structural and Functional Studies of the Unconventional Proteobacterial Transcription Activator Crl in Complex with the Transcription Machinery
… different environmental changes. Crl is a small protein that activates the transcription of σ<sup>S</sup>-dependent genes. In contrast to most transcription activators, Crl does not bind DNA to help recruit RNA polymerase and instead interacts directly with σ<sup>S</sup>. At the outset of …
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SORTASE AND CHEMICAL BIOLOGY AS TOOLS TO STUDY UBIQUITINATION
Ubiquitin, a small protein added post-translationally to proteins, is implicated in a plethora of essential cellular processes including but not limited to protein homeostasis, protein trafficking, cell signaling cascades, and gene expression. Despite nearly 50 years’ worth of scientific research, …
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Structural studies of trans-translation
Ribosomes translate messenger RNA (mRNA) into protein in all living cells. The faultless production of protein is critical for a vast array of catalytic and structural roles and is essential for the survival of the cell. Ribosomes themselves are made up of both RNA and protein, and are composed of …
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On the Structure and Function of Multidrug Efflux Pumps
… (post-translational) behind the association of a small protein called AcrZ with the tripartite complex AcrAB/TolC, in connection with the lipid environment, and the resulting changes in the latter’s functionality (Chapter 2). A regulatory role of the native membrane lipid environment as well as of …
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Characterization of the VtlR regulons in Brucella abortus and Agrobacterium tumefaciens
… include transcriptional regulators and small regulatory RNAs (sRNAs), which can activate and repress gene expression through various interactions with DNA, mRNA, and proteins. A well-conserved transcriptional regulator among the Rhizobiales is VtlR, a virulence-associated transcriptional …
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Exploring Sequence-Structure-Function Relationships in Proteins Using Classification Schemes
With the rapid growth in the number of available protein sequences and structures, the necessity of interpreting this data in comprehensive and meaningful ways becomes increasingly apparent. Identifying and categorizing the functional, structural, and evolutionary relationships between proteins is …
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