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Showing 1 to 7 of 7 for “"small nucleolar RNA"”.
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A Non-Canonical Role for a Small Nucleolar RNA in Ribosome Biogenesis and Cellular Senescence
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The RNA World: A Look at Ribonuclease P RNA, Small Nucleolar RNA, 6S RNA, and the Small Ribosomal Subunit
The term RNA world was first coined in 1986 by W. Gilbert. It was largely based on the observation that RNA, not protein, was responsible for the most critical roles in Bacteria, Archaea and Eukaryotes. Although the RNA world means different things to different researchers Gerald Joyce and Leslie …
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Tandem RNA affinity purifications to study an essential snoRNA in ribosome assembly
… an essential process involving many protein and RNA assembly factors. Mutations of genes encoding ribosomal proteins or assembly factors can result in diseases in humans. The upregulation of ribosome assembly is also a hallmark of many cancers. snR30 is an interesting assembly factor due to its …
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A MECHANISM FOR CORTICAL BONE STEM CELL-DERIVED EXOSOMES’ THERAPEUTIC EFFECT ON POST-MYOCARDIAL INFARCTION REPERFUSION INJURY AND CARDIAC REMODELING
… protective decrease in fibrosis, we performed RNA sequencing on the NHCFs after hCBSC-derived exosome treatment. The group treated with both TGFβ and exosomes showed a decrease in micro RNA (miRNA) and small nucleolar RNA (snoRNA), known to be involved with ribosome stability. A 24hr I/R study …
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Structural Studies of the Nucleolar Stages of Ribosome Biogenesis in Yeast
<p>The ribosome is the RNA-protein machine responsible for the essential task of translating mRNA into proteins. Ribosomes are heterodimers made up of a small subunit (SSU, 40S) and a large subunit (LSU, 60S). At the interface of these subunits, the mRNA is decoded by the small subunit and peptide …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… first centers on how obesity-driven noncoding RNA dysregulation suppresses NK cell fitness and renders cellular immunotherapy ineffective. To identify circulating mediators of obesity-associated immune suppression, snoRNA expression was profiled in human serum across a range of BMI values, …