Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"small molecule screening"”.
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Exploiting Chemical Libraries to Identify and Characterize Novel Bioactives with Efficacy Against Pathogenic Candida Species
… species continues to rise. Here, I employed small-molecule screening and target-based approaches to identify and characterize compounds with novel antifungal activity. Initially, I discovered compounds with novel bioactivity against Candida auris by leveraging the Pathogen Box library. Of the …
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Synthesis and antibacterial evaluation of diverse small molecules
… of new scaffolds, limitations of target-based screening, and poor target validation each contribute to the current bottleneck in the antibiotic pipeline. In turn, I argue that the development and application of chemical probes is a more fruitful way to make progress towards new antibiotics with …
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Novel Approaches for Anthelmintic and Nematicide Discovery
… towards achieving this goal. First, I have used small molecule screening and chemical genetic techniques in C. elegans to identify nematode kinases that hold potential as novel anthelmintic targets. I have complemented this work with in silico approaches to identify those kinases with potential …
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Using chemical biology as a tool to probe the mechanism of the HDL receptor
… Our previous structure/activity analysis of the small-molecule inhibitor, BLT-1, established that the sulfur in the thiosemicarbazone moiety of BLT-1 was essential for its inhibitory activity in lipid transport. This thesis demonstrates that BLT-1 is an irreversible inhibitor of SR-BI, raising …
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Identifying small molecule aggregators with photonic crystal biosensor microplates
Item released from any restrictions by Sarah Shreeves (sshreeve@illinois.edu) on 2013-01-22T11:00:23Z
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Investigating neurodegenerative diseases with small molecule modulators
… of specific aspects of these disease states. Small molecule screening in these cell culture models is a powerful method for identifying novel small molecule modulators of these disease phenotypes. Mechanistic studies of these modulators can reveal vital insights into the cellular pathways …
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Novel Modulation of Adenylyl Cyclase Type 2
… We utilized Gβγ subunit sequestering proteins, small molecule and peptide Gβγ signaling inhibitors, and pharmacological Gβγ effector and kinase inhibitors to study the role of Gβγ subunit signaling pathways in the development of AC2 sensitization in HEK293 cells. Our results suggest that Gβγ …
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Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>
… X-ray crystallography and fragment-based small molecule screening by BLI (Biolayer interferometry) to investigate the ligandability of <i>Af</i>Rho1. Using X-ray crystallography, the structure of <i>Af</i>Rho1 was solved and a complex structure with one of the hit fragments was obtained. …