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Showing 1 to 6 of 6 for “"small molecule mitochondrial uncouplers"”.
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Design and Synthesis of 8-Trifluoromethyl-Substituted Heterocyclic Small Molecule Mitochondrial Uncouplers for the Treatment of Metabolic Diseases
… converted into energy through a process called mitochondrial respiration. Through this process, mitochondria provide over 90% of cellular energy. However, during inflammatory events, mitochondrial respiration is less efficacious and could cause or progress diseases such as obesity, type 2 …
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Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers
… 1-phosphate (S1P) is a cellular signaling molecule that has been implicated in a variety of diseases including cancer, fibrosis, Alzheimer's, and sickle cell disease. It is formed from the phosphorylation of sphingosine (Sph) by sphingosine kinase (SphK) and SphK exists as two …
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Design and Synthesis of Mitochondrial Uncouplers for the Treatment of Mitochondrial Dysfunction
Within the body, mitochondrial has a leading role in many cellular functions including energy production and cell signaling. When mitochondria become dysfunctional diseases such as obesity, type II diabetes mellitus, and metabolic dysfunction-associated steatohepatitis can occur. Mitochondrial …
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Mitochondrial Uncouplers: Development as Therapeutics for Metabolic Diseases
… An alternative therapeutic approach is to use small molecules to uncouple oxidative phosphorylation in the mitochondria by passively shuttling protons from the mitochondrial inner membrane space into the mitochondrial matrix. Mitochondrial uncoupling results in the disruption of the proton …
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Structure-Activity Relationship Studies of Imidazo[4,5-b]pyrazine Derivatives as Mitochondrial Uncouplers and their Potential in the Treatment of Obesity
Mitochondrial uncouplers have the capacity of passively shuttling protons from the mitochondrial intermembrane space to the mitochondrial matrix, independent of ATP synthase. This results in the disruption of oxidative phosphorylation and increased rate of metabolism as a counter action from the …
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Complex Heterocycles as Mitochondrial Uncouplers
Small molecule mitochondrial uncouplers are compounds that dissipate the proton motive force independent of ATP synthase that results in increased energy expenditure. Mild mitochondrial uncoupling has therapeutic potential in treating obesity, diabetes, neurological diseases, non-alcoholic …