Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"small molecule library"”.
-
Development of pattern recognition technique for classification of RNA secondary structures by small molecules
… first time, revealing guiding principles in RNA:small molecule recognition and supporting our long term goal of classifying unknown RNA conformations and even function. Specifically, an aminoglycoside receptor library was obtained with commercially available aminoglycosides and through simple …
-
Structure and Function of a Cytochrome P450 From Synechocystis Sp. PCC 6803
… structure and subsequent in silico docking of a small molecule library identified all-trans retinoic acid as a potential substrate. Optical difference and electron paramagnetic resonance (EPR) spectroscopy show that retinoic acid binds to CYP120A1 with a high affinity. The structures of …
-
Methods and technologies for high-throughput and high-content small animal screening
… health. We subsequently screen the contents of a small-molecule library for factors affecting neural regeneration following femtosecond laser microsurgery of C. elegans using these technologies. This screen identifies the kinase inhibitor staurosporine as a strong inhibitor of neural regeneration, …
-
The preparation of heterocycles by [2+2+2] cyclization and inverse electron demand Dels-Alder reactions of arynes with 1,2,4-triazines
… scaffolds that were utilized further in a small molecule library synthesis. Using this methodology, sixteen new annulated pyridazines were prepared. Inverse electron demand Diels-Alder (IEDDA) reactions of arynes and 1,2,4-triazines were also investigated for the generation of isoquinoline …
-
Characterizing the Activity of Three Novel Differentiation-Inducing Compounds in Neuroblastoma Cells
… content phenotypic screening of a Chembridge small molecule library, three novel neurite-inducing small molecules (Compounds 3, 4, and 10) were identified. The objective of my study is to determine whether the hit compounds have a generic differentiation-inducing effect in neuroblastoma cells …
-
Characterizing and Overcoming Resistance to Aminomethylspectinomycins in Gram-negative Bacteria
… conducted a high throughput screen of a polar small molecule library against two multi-drug resistant clinical isolates of Escherichia coli that encode aminoglycoside modifying enzyme for small molecule potentiators of amSPCs to yield 12 possible potentiating molecules that have been confirmed …
-
Structure Based Drug Design of High Affinity Kras Inhibitors
… the most well characterized membrane-associated small GTPases, is a notorious oncogene with >15% of all tumors harboring RAS mutations. When RAS is mutated it becomes constitutively active sending cell growth, survival and proliferation into overdrive, which subsequently leads to cancer. …
-
Reactions for rapid access to C3a oxygenated pyrroloindolines and its application towards a novel route to pestalazine A
… ghrelin signaling. Through screening a small molecule library by our collabrators, a class of synthetic triterpenoids (CDDO) was identified that efficiently inhibit ghrelin acylation. To verify which functional group was responsible for hGOAT activity, some minimally functionalized …
-
Towards ultrahigh-throughput phenotypic screening using microfluidic droplets and functionalised polyacrylamide beads
Natural evolution has yielded small molecules and macromolecules with a diverse array of activities, many of which have been harnessed by human society to advance industry and medicine. However, evolution is primarily selective for survival of the organism and/or gene rather than any particular …
-
From Probes to Cell Surface Labelling: Towards the Development of New Chemical Biology Compounds and Methods
… system using chemistry, often by virtue of small molecules or unnatural amino acids. Much insight has been gained into the mechanisms of biological processes with regards to protein structure and function, metabolic processes and changes between healthy and diseased states. As an ever …
-
Turn-on fluorescent probes for detecting nitric oxide in biology
… of the exact functions of these important biomolecules has been hampered by the inability to detect RNS reliably under biological conditions. A surge of research into RNS chemistry has resulted in the design of a new generation of fluorescent probes that are specific and sensitive for their …