Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"small molecule compound"”.
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The Role Of ROS-mediated ERK and JNK Activation In The Induction Of Autophagy And Apoptosis In Tumour Cells By A Novel Small Molecule Compound
… factor deprivation or upon exposure to genotoxic compounds. It should be noted that autophagy has been described as a cell survival mechanism as well as a death execution pathway. Using a novel small molecule 1,3-dibutyl-2-thiooxo-imidazolidine-4,5-dione (C1), which is a strong inducer of …
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Transcriptional Elongation is Important for Neural Crest Development
… and sensory neurons [1, 2]. Here I show that the small molecule compound leflunomide is able to inhibit neural crest specification genes. Leflunomide exerts its actions by inhibiting pyrimidine synthesis and therefore RNA transcription [4]. Neural crest genes are thought to be actively transcribed …
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Quantitative analysis of the effect of leflunomide on neural crest cell gene regulation during early embryonic development
… interactions is still not fully understood. The small molecule compound leflunomide inhibits neural crest development. Leflunomide’s mode of action is to inhibit pyrimidine biosynthesis, thereby, preventing RNA transcription. Neural crest genes are actively transcribed and like many embryonic …
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Functional Analysis of the Tumor Metastasis Suppressor, NDRG1
… also found that restoring NDRG1 expression by a small molecule compound significantly suppressed the capability of otherwise highly metastatic tumor cells to thrive in circulation and distant organs in animal models. In addition, our analysis of clinical cohorts data indicate that Wnt+/NDRG-/LRP+ …
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Investigating the nuclear import protein KPn߀1 as a cancer therapeutic target
… an in silico screening approach to identify small molecule inhibitors of Kpnβ1 with anti-cancer activity, a number of compounds were selected for further investigation in our laboratory. The aim of this study was to investigate a novel small molecule, Compound 60 …
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Autogramin-2, a synthetic sterol, inhibits T cell adhesion and effector function
Plasma membrane resident cholesterol is a key regulator of T cell immunity as it stabilises immune synapses, thus supporting effector T cell function. Recent publications suggest that increasing plasma membrane cholesterol content boosts anti-viral and anti-cancer immunity in T cells. Inhibition of …
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Reprogramming to Pluripotency Using Small Molecule Compounds
… stem cells (iPSCs) through the use of small molecule compounds has evolved as a potential cellular reprogramming strategy. Individually, specific small molecule compounds have previously been shown to replace reprogramming transcription factors or enhance the efficiency of cellular …