Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"small molecular inhibitors"”.
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Investigation of the action of phosphatase of regenerating liver on PTEN using murine models
… PTEN. We also found that PRL 2 is targetable by small molecular inhibitors that can potentially be used to disrupt tumor growth and spermatogenesis. Furthermore, a PTEN heterozygous mouse model crossed into our PRL 2 knockout line was generated to investigate the relevance of PRL interaction with …
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Small molecules with anti-trypanosomal and anti-leishmanial activity
… is virtually dry and the trickle of inhibitors that are in development are largely based on those that are already in use. Parasite resistance to these drugs is developing, underlining the urgent need for novel anti-parasitic drug therapies. This study focused on the identification of …
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Insights into the role of PFKFB3 in cancer
… the therapeutic potential of novel PFKFB3 inhibitors as well as the molecular mechanism of PFKFB3 inhibition. I was able to identify small molecular inhibitors, N4A and YN1, which almost constantly inhibit PFKFB3 and ultimately lead to cancer cell death. I determined the crystal structure …
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Discovery of novel highly selective Rho kinase (ROCK) inhibitory peptides and evaluation of their biological activities
… to inhibit ROCK activity. However, most of these small molecular inhibitors of ROCK are type I which compete with ATP to bind to the ATP binding site on catalytic domain of ROCK in its active conformation and since the ATP binding site is highly conserved in kinases, these inhibitors can cause …
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The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma
… demonstrated that the development of novel inhibitors targeting the redox regulation domain of APE/Ref-1 is a promising strategy for melanoma treatment. To date, limited successes have been reported in developing novel APE/Ref-1 inhibitors for cancer treatment. Utilizing a structure-based …
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Small molecule inhibitors against enteric bacterial glycosyltransferases
… and Citrobacter rodentium. T3SS resembles a molecular syringe structure to inject secreted effector proteins directly from the bacterial cell into the host cell. Our goal is to look for anti-bacterial virulence therapies by targeting important T3SS effectors. In our first project, we targeted …
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Evaluating The Therapeutic Efficacy of Grb2 Inhibition In Ovarian Malignancies
<p><strong>Purpose: </strong>Adaptor proteins such as growth factor receptor-bound protein-2 (Grb2) play important roles in cancer cell signaling. In the present study, we examined the biological effects of liposomal antisense oligodeoxynucleotide that blocks Grb2 expression (L-Grb2) in ovarian …
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Chemoprevention of Lung Carcinogenesis: Aerosol Administration and Deposition in the Mouse Lung
… studies. However, because mice have much smaller lungs than those of human beings, the lung deposition data attained for humans cannot be applied to the mouse. Hence few studies have focused on particle deposition in the mouse lung. It is thus necessary to measure the mass deposition of …